|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer显示文摘前面的 gradient-2 (AGR2 ) 支持肿瘤生长,房间移植和细胞的转变和它的提高的表达式几乎完全被限制为恶意的纸巾,因此为 immunotherapeutic 策略的开发使 AGR2 成为一个有趣的目标。我们调查了 AGR2 分子是否包括抗原(HLA )-A*0201-binding epitopes 由人的细胞毒素的 T 淋巴细胞(CTL ) 认出了的人的白血球,它能在基于的树枝状的房间(DC ) 被指向对 colorectal 癌症(CRC ) 的癌症免疫疗法。我们为能潜在地绑在 HLA-A* 的肽考察了 AGR2 的顺序; 0201 在一个基于计算机的节目的帮助下。有不同有约束力的分数的五候选人肽被综合并且测试。这些肽然后被估计因为他们得到特定的有免疫力的回答的 immunogenicity 借助于连接酶的 immunospot 试金和 CTL 试金在 vitro 由 CTL 调停了。AGR2 高度在几根 CRC 房间线被表示,包括 DK01, DLD1, KM12C, HCT-8 和 HT-29。DC 与 AGR2-P2 搏动了(aa 11-19;LLVALSYTL ) 或 AGR2-P4 (aa 127-135;RIMFVDPSL ) 产生有势力 CTL 能细胞溶解 T2 房间与 AGR2-P2 或 AGR2 积极的 CRC 房间在一个强壮的剂量依赖者和 HLA-A* 衬里的 AGR2-P4 和 HLA-A0201 + 搏动了; 0201-restricted 举止。在结论,从 AGR2 蛋白质导出的这些新奇 epitopes 可以是为 CRC 的基于 DC 的免疫疗法的吸引人的候选人。 | Hyun Ju Lee Cheol Yi Hong Chun-Ji Jin Mi-Hyun Kim Youn-Kyung Lee Thanh-Nhan Nguyen-Pham Hyunah Lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2012 | Cellular & Molecular Immunology2012，9，2： | 1 |
| 2 | Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae显示文摘 | Eun Young Cho Seon Ah Cheon Hyunah Kim Jinho Choo Dong-Jik Lee Ho Myung Ryu Sang Ki Rhee Bong-Hyun Chung Jeong-Yoon Kim Hyun Ah Kang | 2010 | Journal of Biotechnology2010，，1： | 1 |
| 3 | Use of complementary and alternative medicine by arthritis patients in a university hospital clinic serving rheumatology patients in Korea显示文摘 | HyunAh Kim and Yeong-II Seo | 2003 | Rheumatology International2003，23，6： | 1 |
| 4 | Oct4‐induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model显示文摘 | Jeong Beom Kim Hyunah Lee Marcos J Araúzo‐Bravo Kyujin Hwang Donggyu Nam Myung Rae Park Holm Zaehres Kook In Park Seok‐Jin Lee | 2015 | EMBO J2015，，23： | 1 |
| 5 | Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity显示文摘Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune system.NK cells without any genetic modifications have been used for both autologous and allogeneic therapies.Moreover,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2]. | Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho | 2022 | Cellular & Molecular Immunology2022，19，2： | 0 |
| 6 | Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase Ⅰ/Ⅱ trial显示文摘当卵巢的癌症(OvCa ) 对外科和常规化疗作出回应很好时,先进 OvCa 的高复发率被观察。在这阶段 I/II 研究,有最小的剩余疾病的 10 个 OvCa 病人与自体同源的树枝状的房间(DC ) 和 IL-2 被对待评估这治疗学的策略的安全和可行性并且描绘通过这治疗导致的抗原特定的有免疫力的改变。在起始的 debulking 和化疗以后的约 4 个月,病人们收到了自体同源的导出单核白血球的 DC 的二下的剂量在 4 星期的间隔与自体同源的肿瘤 lysate 和锁眼恋栈者 hemocyanin (KLH ) 搏动了。在每 DC 接种以后,低剂量(200 mIU ) IL-2 作为一个有免疫力的助手被介绍 14 连续的天。种痘很好被容忍。没有疾病恶化,在三,从 10 个病人,,在起始的治疗以后的包括地位在 DC 种痘以后显示出完全的宽恕(CR ) 的维护 83, 80.9 和 38.2 个月。有稳定的疾病(SD ) 的一个病人在 DC 种痘以后经历了肿瘤的完全的消失,并且这地位被维持 50.8 个月直到肿瘤复发。在二,有部分反应(PR ) 的病人不正在回答种痘和他们的疾病复发了到 DC。在有疾病的三个病人免费长期的幸存,重要有免疫力的改变被观察,包括的增加的生来的杀手(NK ) 活动, IFN-γ在 DC 种痘以后的 -secreting T 房间, immune-stimulatory cytokine 分泌物和减少的免疫者镇压的因素分泌物。在有 NED 地位和增加的全面幸存的病人,因此, DC 种痘导致了肿瘤相关的免疫,潜在地对 OvCa 与长期的临床的回答联系了。 | Soyoung Baek Yong-Man Kim Sung-Bae Kim Choung-Soo Kim Seog-Woon Kwon YongMan Kim HyunSoo Kim Hyunah Lee | 2015 | Cellular & Molecular Immunology2015，12，1： | 0 |
| 7 | Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea显示文摘Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in Korea.We compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first time.We analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years after.We included 3678 patients and analyzed the changes in GFR.The GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,P<0.001).When comparing the GFR among different statins,significant differences were observed between atorvastatin and fluvastatin(−5.3%±0.7%vs.1.2%±2.2%,P<0.05)and between atorvastatin and simvastatin(−5.3%±0.7%vs.−0.7%±0.8%,P<0.05).In pitavastatin(odds ratio[OR]=0.64,95%confidence interval[CI]=0.46-0.87,P<0.005)and simvastatin(OR=0.69,95%CI=0.53-0.91,P<0.008),the GFR rate that decreased by<60 mL/min/1.73 m2 was significantly lower than that of atorvastatin.Regarding long-term statin intake,GFR changed with the type of statin.This work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription. | Seo Yeon Baik Hyunah Kim So Jung Yang Tong Min Kim Seung-Hwan Lee Jae Hyoung Cho Hyunyong Lee Hyeon Woo Yim Kun-Ho Yoon Hun-Sung Kim | 2019 | Frontiers of Medicine2019，13，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员