|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction:A systematic review显示文摘AIM: To conduct a systematic review relating myocardial strain assessed by different imaging modalities for prognostication following ST-elevation myocardial infarction(STEMI).METHODS: An online literature search was performed in Pub Med and OVID® electronic databases to identify any studies that assessed global myocardial strain parameters using speckle-tracking echocardiography(STE) and/or cardiac magnetic resonance imaging(CMR) techniques [either myocardial tagging or feature tracking(FT) software] in an acute STEMI cohort(days 0-14 post-event) to predict prognosis [either development of major adverse cardiac events(MACE)] or adverse left ventricular(LV) remodelling at follow-up(≥ 6 mo for MACE,≥ 3 mo for remodelling). Search was restricted to studies within the last 20 years. All studies that matched the pre-defined search criteria were reviewed and their results interpreted. Due to considerable heterogeneity between studies,metaanalysis was not performed.RESULTS: A total of seven studies(n = 7) were identified that matched the search criteria. All studies used STE to evaluate strain parameters- five(n = 5) assessed global longitudinal strain(GLS)(n = 5),one assessed GLS rate(GLS-R)(n = 1) and one assessed both(n = 1). Three studies showed that GLS independently predicted the development of adverse LV remodelling by multivariate analysis- odds ratio between 1.19(CI: 1.04-1.37,P < 0.05) and 10(CI: 6.7-14,P < 0.001) depending on the study. Four studies showed that GLS predicted the development of MACE- hazard ratio(HR) between 1.1(CI: 1-1.1,P = 0.006) and 2.34(1.10-4.97,P < 0.05). One paper found that GLS-R could significantly predict MACEHR 18(10-35,P < 0.001)- whilst another showed it did not. GLS <-10.85% had sensitivity/specificity of 89.7%/91% respectively for predicting the development of remodelling whilst GLS <-13% could predict the development of MACE with sensitivity/specificity of 100%/89% respectively. No suitable studies were identified that assessed global strain by CMR tagging or FT techniques.CONCLUSION: GLS measured acutely post-STEMI by STE is a predictor of poor prognosis. Further research is needed to show that this is true for CMR-based techniques. | Abhishek Shetye Sheraz A Nazir Iain B Squire Gerald P McCann | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 3 | The physiological roles of dietary fibre显示文摘 | Iain A Brownlee | 2011 | Food Hydrocolloids2011，，25： | 1 |
| 4 | Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis显示文摘 | NATALIA I ALEXEI S IAIN A | 2003 | Nature2003，423，： | 1 |
| 5 | Predicting surfactant modified soil/water distribution coefficients using micellar HPLC显示文摘 | Paterson Iain F Chowdhry Babur Z Leharne Stephen A | 1999 | Chemosphere1999，2，38： | 1 |
| 6 | Fault-tolerant Embeddings of Hamiltonian Circuits in k-ary n-cubes显示文摘 | Ashir Yaagoub A Stewart Iain A | 2002 | SIAM Journalon Discrete Mathematics2002，15，3： | 1 |
| 7 | Biomedical research: increasing value, reducing waste显示文摘 | Malcolm R Macleod Susan Michie Ian Roberts Ulrich Dirnagl Iain Chalmers John P A Ioannidis Rustam Al-Shahi Salman An-Wen Chan Paul Glasziou | 2014 | The Lancet . 2014 (9912)2014，，9912： | 1 |
| 8 | Effective leadership and decision-making in animal groups on the move显示文摘 | Iain D C Krause J Simon A L | 2005 | Nature2005，433，7025： | 1 |
| 9 | Regeneration of plants from leafexplants ofmicropropagated clonal Eucalyptus grandis 显示文摘 | Iaine E Dvid A | 1994 | Plant Cell Reports1994，，13： | 1 |
| 10 | Evaluationof a Series of Bicyclic CXCR2 Antagonists显示文摘 | IAIN W CAROLINE A RUPERT A | 2008 | BioQrgMed Chem Lett2008，18，2： | 1 |
| 11 | Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach显示文摘 | Guennadi A K Iain M P Julian B J | 2004 | Proteome Science2004，，2： | 1 |
| 12 | Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR显示文摘 | Linda A L Ben C | 2002 | Journal of Photochemistry and Photobiology A:Chemistry2002，148，： | 1 |
| 13 | Mechanistic and oxideity studies of the photocatalytic oxidation of microcystin-LR 显示文摘 | IAIN L LINDA A L BEN C | 2002 | Chemistry2002，148，13： | 1 |
| 14 | The physiological roles of dietary fibre显示文摘 | Iain A Brownlee | 2011 | Food Hydrocolloids2011，，25： | 1 |
| 15 | A Biomechanical Comparison of Plate Configuration in Distal Humerus Fractures显示文摘 | Magnus W T Arnander Alexander Reeves Iain A R MacLeod Thomas M Pinto Arshad Khaleel | 2008 | Journal of Orthopaedic Trauma2008，，5： | 1 |
| 16 | Water absorption in a rubber- modified epoxy resin; carboxy terminated butadiene acrylonitrile-amine cured epoxy resin system显示文摘 | IAIN MCEWAN RICHARD A PETHRICK STEPHEN J SHAW | 1999 | Polymer1999，40，： | 1 |
| 17 | The physiological roles of dietary fiher显示文摘 | Iain A Brown Lee | 2011 | Food Hydrocolloids2011，25，： | 1 |
| 18 | Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR显示文摘 | IAIN L LAWTON L A CORNISH B | 2002 | J Phot Phot A:Chem2002，148，13： | 1 |
| 19 | Optical design dependence on technology显示文摘 | IAIN A NEIL | 2011 | Optical Engineering2011，50，12： | 1 |
| 20 | Environmentally Adjusted Productivity Measurement:An Australian Case Study显示文摘 | Nanere M Iain F Quazi A | 2007 | Journal of Environmental Management2007，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员