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| 1 | Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction:A systematic review显示文摘AIM: To conduct a systematic review relating myocardial strain assessed by different imaging modalities for prognostication following ST-elevation myocardial infarction(STEMI).METHODS: An online literature search was performed in Pub Med and OVID® electronic databases to identify any studies that assessed global myocardial strain parameters using speckle-tracking echocardiography(STE) and/or cardiac magnetic resonance imaging(CMR) techniques [either myocardial tagging or feature tracking(FT) software] in an acute STEMI cohort(days 0-14 post-event) to predict prognosis [either development of major adverse cardiac events(MACE)] or adverse left ventricular(LV) remodelling at follow-up(≥ 6 mo for MACE,≥ 3 mo for remodelling). Search was restricted to studies within the last 20 years. All studies that matched the pre-defined search criteria were reviewed and their results interpreted. Due to considerable heterogeneity between studies,metaanalysis was not performed.RESULTS: A total of seven studies(n = 7) were identified that matched the search criteria. All studies used STE to evaluate strain parameters- five(n = 5) assessed global longitudinal strain(GLS)(n = 5),one assessed GLS rate(GLS-R)(n = 1) and one assessed both(n = 1). Three studies showed that GLS independently predicted the development of adverse LV remodelling by multivariate analysis- odds ratio between 1.19(CI: 1.04-1.37,P < 0.05) and 10(CI: 6.7-14,P < 0.001) depending on the study. Four studies showed that GLS predicted the development of MACE- hazard ratio(HR) between 1.1(CI: 1-1.1,P = 0.006) and 2.34(1.10-4.97,P < 0.05). One paper found that GLS-R could significantly predict MACEHR 18(10-35,P < 0.001)- whilst another showed it did not. GLS <-10.85% had sensitivity/specificity of 89.7%/91% respectively for predicting the development of remodelling whilst GLS <-13% could predict the development of MACE with sensitivity/specificity of 100%/89% respectively. No suitable studies were identified that assessed global strain by CMR tagging or FT techniques.CONCLUSION: GLS measured acutely post-STEMI by STE is a predictor of poor prognosis. Further research is needed to show that this is true for CMR-based techniques. | Abhishek Shetye Sheraz A Nazir Iain B Squire Gerald P McCann | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 2 | 白细胞介素-33促进胶原诱导性关节炎的实验研究显示文摘目的探讨新型细胞因子白细胞介素(IL)-33在胶原诱导性关节炎(CIA)发病中的作用。方法建立DBA/1小鼠的CIA模型。以牛II型胶原(CII),完全福氏佐剂(CFA)免疫,从免疫后第21天开始每天注射IL-33或磷酸盐缓冲液(PBS)共5d。免疫后第28天取小鼠淋巴结细胞体外培养,培养上清的细胞因子浓度以酶联免疫吸附试验(ELISA)法检测或Luminex检测。同时检测血清中抗Ⅱ型胶原抗体和血清中的细胞因子浓度。鼠爪脱钙后行病理检查。采用两样本均数的t检验、r检验进行统计学处理。结果IL-33可使小鼠实验性的关节炎发病加重,致炎性细胞因子和抗Ⅱ型胶原抗体产生增多(P〈0.05),PBS组与IL-33组的IgG2a型Ⅱ型胶原抗体为[(1.24±0.33)mg/L和(1.96±0.16)mg/L,P〈0.05],而IgGl型抗Ⅱ型胶原抗体为[(1.1±0.4)mg/L和(1.7±0.4)mg/L,P〈0.05]。结论IL-33是炎性关节病中的重要致炎因子。这一IL-1家族新成员是潜在的类风湿关节炎(RA)治疗靶点。 | 穆荣 蒋慧蓉 李玉宾 Iain B McIness 栗占国 | 2010 | 中华风湿病学杂志2010，14，3： | 2 |
| 3 | A Reviewand Analysis of Current Computer-Aided Fixture DesignApproaches 显示文摘 | B O Y L E Iain R O N G Yiming B R O W N David C | 2011 | Robotics and Computer-Integrated Manufacturiiig2011，27，1： | 1 |
| 4 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 5 | Momentum and heat transfer in a laminar boundary layer with slip flow显示文摘 | Michael J M Iain D B | 2006 | Journal of Thermophysics and Heat Transfer2006，20，4： | 1 |
| 6 | Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach显示文摘 | Guennadi A K Iain M P Julian B J | 2004 | Proteome Science2004，，2： | 1 |
| 7 | Characteristics of MIMO-OFDM Channels in Indoor Environments显示文摘 | Hajime Suzuki Thi Van Anh Tran Iain B Collings | 2007 | EURASIP Journal on Wireless Communications and Networking2007，，9： | 1 |
| 8 | Active appearance models revisited显示文摘 | Iain M Simon B | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 9 | Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR显示文摘 | IAIN L LAWTON L A CORNISH B | 2002 | J Phot Phot A:Chem2002，148，13： | 1 |
| 10 | Emerging cytokine targets in rheumatoid arthritis显示文摘 | Darren L Asquith Iain B McInnes | 2007 | Current Opinion in Rheumatology2007，，3： | 1 |
| 11 | Cities and Competitiveness 显示文摘 | IAIN B | 1999 | Urban Studies1999，36，56： | 1 |
| 12 | The physiological roles of dietary fibre显示文摘 | IAIN A B | 2011 | FoodHydrocolloids2011，25，2： | 1 |
| 13 | Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells显示文摘 | Iain B Kawan S Sarah LM | 2004 | Breast Cancer2004，6，： | 1 |
| 14 | Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells显示文摘 | Iain B Kawan S Sarahl M | | 0，，05： | 1 |
| 15 | Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage显示文摘 | Rhoda Wilson Carol Jenkins Helen Miller Iain B McInnes Judith Moore Marjorie A McLean James J Walker | 2004 | European Journal of Obstetrics and Gynecology2004，，1： | 1 |
| 16 | Fast and accurate NURBS fitting for reverse engineering 显示文摘 | DJORDJE B IAIN A MIHAILO R | 2011 | Int J of Adv Manuf Technol2011，54，5678： | 1 |
| 17 | Sepsis, SIRS, and MODS 显示文摘 | Griffiths B Iain D | 2009 | Surgery (Oxford)2009，27，10： | 1 |
| 18 | IL-10 improves skin disease and modulates endothelial activation and leukocyte Effector function in patients with psoriatic arthritis显示文摘 | Iain B McInnes Gabor G | | 0，，07： | 1 |
| 19 | Funding Higher Education in an Ageof Expansion显示文摘 | Nicholas B Iain C | 1998 | Education Economics1998，100，6： | 1 |
| 20 | Cities and competitiveness 显示文摘 | IAIN B | 1999 | Urban Stud- ies1999，，： | 1 |
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