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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver:a clinical and pharmacologic evaluation显示文摘 | van Iersel LB Verlaan MR Vahrmeijer AL | 2007 | Eur J Surg Oncol2007，33，： | 1 |
| 4 | Riskbased selection from the general population in a screening trial:Selection criteria,recruitment and power for the Dutch-Belgian randomised lung cancer Multi-slice CT screening trial (NELSON)显示文摘 | Van Iersel CA De Koning HJ Draisma G | 2007 | Int J Cancer2007，120，： | 1 |
| 5 | Safety, tolera- bility and pharmacokinetics of sugammadex using single high doses ( up to 96 mg' kg- l ) in healthy aduh sub- jects: a randomized, double-blind, crossover, placebo- controlled, single-centre study 显示文摘 | Peeters PA van den Heuvel MW van Heumen E Ias- sier PC Smeets JM van Iersel T | 2010 | Clin Drug Invest2010，30，12： | 1 |
| 6 | Palliative care physicians' religious/world view and attitude towards euthanasia: a quantitativestudy among Flemish palliative care physicians显示文摘 | Broeckaert B Gielen J Van Iersel T | 2009 | Indian J Palliat Care2009，15，1： | 1 |
| 7 | Risk-based selection from the general population in a screening trial: Selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON) 显示文摘 | van Iersel CA de Koning HJ Draisma G | 2007 | Int J Cancer2007，120，4： | 1 |
| 8 | Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer creening trial ( NELSON ) 显示文摘 | Van Iersel CA de Koning HJ Draisma G | 2007 | Int J Cancer2007，120，4： | 1 |
| 9 | Im- portance of acoustic shielding in sonochemistry显示文摘 | IERSEL M M V BENES N E KEURENTJES J T F | 2008 | Ultra- sonics Sonochemistry2008，15，4： | 1 |
| 10 | Hyperhomo- cysteinemia, pregnancy complications, and the timing of investigation 显示文摘 | Steegers-Theunissen RP Van Iersel CA Peer PG | 2004 | Obstetrics & Gynecology2004，104，2： | 1 |
| 11 | WikiPathways: building research communities on biological pathways 显示文摘 | Kelder T van Iersel MP Hanspers K | 2011 | Nucleic Acids Res2011，40，1： | 1 |
| 12 | An automated system for controlling drought stress and irrigation in potted plants显示文摘 | Krishna S. Nemali Marc W. van Iersel | 2006 | Scientia Horticulturae2006，，3： | 1 |
| 13 | WikiPathways: pathway editing for the people 显示文摘 | Pico AR Kelder T van Iersel MP | 2008 | PLoS Biol2008，6，7： | 1 |
| 14 | The complexity of the single individual SNP haplotyping problem显示文摘 | CILIBRASI R IERSEL L V KELK S | 2007 | Algorithmica2007，49，1： | 1 |
| 15 | Risk-based general population in a screening trial Selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON)显示文摘 | van Iersel CA de selection from the Koning HJ Draisma G | 2007 | Int J Cancer2007，120，4： | 1 |
| 16 | Safety and tolerability of the antimicrobial peptide human lacto- ferrin 1-11 (hLFI-11)显示文摘 | VANDEN WJ VAN IERSEL TM BLIJLEVENS NM | 2009 | BMCMed2009，7，： | 1 |
| 17 | Phylogenetic networks do not need to be complex:using fewer reticulations to represent conflicting clusters显示文摘 | VAN IERSEL L KELK S RUPP R | | 0，，12： | 1 |
| 18 | Root restriction effects on growth and development of salvia (Salviasplendens) 显示文摘 | Van Iersel M | 1997 | Hort- science1997，32，7： | 1 |
| 19 | Safety and tolerability of the antimicrobial peptide human lacto- fen-in 1-11 (hLFI-11)显示文摘 | VELDEN WJ VAN IERSEL TM BLIJLEVENS NM | 2009 | BMC Med2009，7，： | 1 |
| 20 | Hyperhomo- cysteinemia,Pregnancy complications,and the timing of investiga- tion显示文摘 | Steegers theunissen RP Van iersel CA Peer PG | 2004 | Obstet Gyneco12004，104，2： | 1 |
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