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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact显示文摘 | Ilona Q Madeleine R B Margot Van de B | 2013 | Environ Res Public Health2013，10，8： | 1 |
| 4 | Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats显示文摘 | Majken Dalgaard Ulla Hass Anne Marie Vinggaard Kirsten Jarfelt Henrik R Lam Ilona K S?rensen Helle M Sommer Ole Ladefoged | 2003 | Reproductive Toxicology2003，，2： | 1 |
| 5 | Pregnancy Induced Adaptation in the Neuroendocrine Control of Prolactin Secre- tion显示文摘 | David R G Frederik J S Ilona C K etal | 2008 | Journal of Neuroendocrinology2008，20，： | 1 |
| 6 | Spectroscopic characterization of chrysotile asbestos from different regions显示文摘 | MIRA R ILONA C N SVETOZAR M | 2011 | Journal of Molecular Structure2011，993，： | 1 |
| 7 | Estimating the gas permeability of commercial volatile corrosion inhibitors at elevated temperatures with thermo-gravimetry显示文摘 | Niel Pieterse Walter W. Focke Eino Vuorinen Ilona Rácz | 2005 | Corrosion Science2005，，8： | 1 |
| 8 | Direct recovery of in-fectious Pestivirus from a full-length RT-PCR amplicon 显示文摘 | Thomas B R Ilona R Bemd H | 2008 | Virol Methods2008，149，2： | 1 |
| 9 | CP7 E2alf:a safe and efficient marker vaccine strain for oral immunisation of wild hoar against classical swine fever virus (CSFV)显示文摘 | Patricia K Elke L Ilona R | | 0，，： | 1 |
| 10 | Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic显示文摘 | Stanislav Rejchrt Ilona Koupil Marcela Kopá?ová Viktor Vo?í?ek Bohumil Seifert Old?ich Pozler Pavel ?ivny Tomá? Douda Vladimír Pali?ka Jan Hol?ík Jan Bure? | 2008 | European Journal of Gastroenterology & Hepatology2008，，9： | 1 |
| 11 | Effects of the available nitrogen on the photosynthetic activity and xanthophyll cycle pool of maize in field 显示文摘 | Viktor R T Ilona M Szilvia V | 2002 | Journal of Plant Physiology2002，159，6： | 1 |
| 12 | TNF-α messenger RNA and protein expression in the uteroplacental unit of mice with pregnancy loss显示文摘 | Marat G O Ilona Z E Hasida O R | 1998 | J Immunol1998，160，9： | 1 |
| 13 | Intraplatelet calcium levels in patients with acute renal failure before an after the administration of loop diuretics显示文摘 | Allison Marjorie EM | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 14 | Genotypic and phenotypic characterization of Pseudomonas aeruginosa isolates from urinary tract infections显示文摘 | Petra Tielen Maike Narten Nathalie Rosin Ilona Biegler Isam Haddad Michael Hogardt Rüdiger Neubauer Max Schobert Lutz Wiehlmann Dieter Jahn | 2010 | International Journal of Medical Microbiology2010，，4： | 1 |
| 15 | Prolonged Survival Using Anti-CD20 Combined Chemotherapy in Primary Prostatic Intravascular Large B-cell Lymphoma显示文摘 | Judit Csomor Ilona Kaszás Balázs Kollár László Pajor Zsolt Egyházi Sándor Fekete Miklós Egyed Botond Timár | 2008 | Pathology & Oncology Research2008，，3： | 1 |
| 16 | Novel marker vac- cines against classical swine fever显示文摘 | MARTIN B ILONA R BERND H | 2007 | Vaccine2007，25，30： | 1 |
| 17 | The how neurotoxic dynamics of autism compounds and neurotransmitters interact 显示文摘 | Ilona Q Madeleine R spectrum disorders : B Margot V B | 2013 | Environ Res Public Health2013，10，8： | 1 |
| 18 | BAC Consensus Conference, November 4–6, 2004: Epidemiology, Pathogenesis, and Preclinical Models显示文摘 | David C. Christiani William Pao James C. DeMartini R Ilona Linnoila Alvin M. Malkinson Amir Onn Katerina A. Politi Michael Sharp Kwok- Kim | 2006 | Journal of Thoracic Oncology . 2006 (9 Su)2006，，9： | 1 |
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