|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer显示文摘AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer. | Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto | 2007 | World Journal of Gastroenterology2007，13，21： | 8 |
| 2 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 3 | Differential roles of EPS8 in carcinogenesis:Loss of protein expression in a subset of colorectal carcinoma and adenoma显示文摘AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment. | Wael M Abdel-Rahman Salla Ruosaari Sakari Knuutila Pivi Peltomki | 2012 | World Journal of Gastroenterology2012，18，29： | 5 |
| 4 | Methods, units and quality requirements for the analysis of haemoglobin A_(1c) in diabetes mellitus显示文摘The formation of glycohemoglobin, especially the hemoglobin A1c(Hb_(A1c)) fraction, occurs when glucose becomes coupled with the amino acid valine in the β-chain of Hb; this reaction is dependent on the plasma concentration of glucose. Since the early 1970 s it has been known that diabetics display higher values of Hb_(A1c) because they have elevated blood glucose concentrations. Thus Hb_(A1c) has acquired a very important role in the treatment and diagnosis of diabetes mellitus. After the introduction of the first quantitative measurement of Hb_(A1c), numerous methods for glycohemoglobin have been introduced with different assay principles: From a simple minicolumn technique to the very accurate automated highpressure chromatography and lastly to many automated immunochemical or enzymatic assays. In early days, the results of the quality control reports for Hb_(A1c) varied extensively between laboratories, therefore in United States and Canada working groups(WG) of the Diabetes Controls and Complications Trial(DCCT) were set up to standardize the Hb_(A1c) assays against the DCCT/National Glycohemoglobin Standardization Program reference method based on liquid chromatography. In the 1990 s, the International Federation of Clinical Chemistry and Laboratory Medicine(IFCC) appointed a new WG to plan a reference preparation and method for the Hb_(A1c) measurement. When the reference procedureswere established, in 2004 IFCC recommended that all manufacturers for equipment used in Hb_(A1c) assays should calibrate their methods to their proposals. This led to an improvement in the coefficient of variation(CV%) associated with the assay. In this review, we describe the glycation of Hb, methods, standardization of the Hb_(A1c) assays, analytical problems, problems with the units in which Hb_(A1c) values are expressed, reference values, quality control aspects, target requirements for Hb_(A1c), and the relationship of the plasma glucose values to Hb_(A1c) concentrations. We also note that the acceptance of the mmol/mol system for Hb_(A1c) as recommended by IFCC, i.e., the new unit and reference ranges, are becoming only slowly accepted outside of Europe where it seems that expressing Hb_(A1c) values either only in per cent units or with parallel reporting of percent and mmol/mol will continue. We believe that these issues should be resolved in the future and that it would avoid confusion if mmol/mol unit for Hb_(A1c) were to gain worldwide acceptance. | Ilkka Penttil? Karri Penttil? P?ivi Holm Harri Laitinen P?ivi Ranta Jukka T?rr?nen Rainer Rauramaa | 2016 | World Journal of Methodology2016，6，2： | 3 |
| 5 | ApoE基因对急性缺血性脑卒中的影响:磁共振成像研究显示文摘ApoEε4等位基因对急性缺血性脑卒中兼具危害和保护效应。ApoEε4等位基因的危害效应表现在梗死体积增加更多,脑组织损伤的血供阈值低,病人临床愈后与影像学发现不成比例。但是ApoEε4等位基因携带者有更完好的侧支循环。涉及ApoEε4等位基因和临床愈后的研究显示,危害和保护效应可能会相互抵消。在今后的缺血性脑卒中影像学和临床愈后研究中,ApoEε4等位基因干扰效应需要加以控制。 | 刘亚武 Pivi Hartikainen Ritva L.Vanninen | 2010 | 国际医学放射学杂志2010，33，5： | 2 |
| 6 | Detection of recurrent cervical cancer by whole-body FDG PET scan in asymptomatic and symptomatic women 显示文摘 | Unger JB Ivy JJ Connor P | 2005 | Obstet Gynecol Surv2005，60，1： | 1 |
| 7 | PCDD/Fs, PCBs and PBDEs in zooplankton in the Baltic Sea-Spatiai and temporal shifts in the congener-specific concentrations显示文摘 | Heikki P P?ivi R Markku K | 2014 | Chemosphere2014，114，： | 1 |
| 8 | Effect of processing on the extractability of oat β-glucan显示文摘 | Liisa Johansson P?ivi Tuomainen Heli Anttila Hannu Rita Liisa Virkki | 2007 | Food Chemistry2007，，4： | 1 |
| 9 | Utilisation of a multitubular reactor system for parallel screening of catalysts for ring opening of decalin in continuous mode显示文摘 | Kalle Arve P?ivi M?ki-Arvela Kari Er?nen Marja Tiitta Tapio Salmi Dmitry Yu. Murzin | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 10 | Hydrolytic stability of nucleoside phosphotriesters derived from bis(hydroxymethyl) -1,3-dicarbonyl compounds and their congeners:towards a novel pro-drug strategy for antisense oligonucleotides显示文摘 | Esa Mki Pivi Poijrvi | 2001 | J Chem Soc:Perkin Trans 22001，，： | 1 |
| 11 | Surgical or Nonoperative Treatment for Lumbar Spinal Stenosis?: A Randomized Controlled Trial显示文摘 | Antti Malmivaara P?r Sl?tis Markku Heli?vaara P?ivi Sainio Heikki Kinnunen Jyrki Kankare Nina Dalin-Hirvonen Seppo Seitsalo Arto Herno Pirkko Kortekangas Timo Niinim?ki Hannu R?nty Kaj Tallroth Veli Turunen Paul Knekt Tommi H?rk?nen Heikki Hurri | 2007 | Spine2007，，1： | 1 |
| 12 | Ligation of the suprarenal vena cava after a gunshot wound显示文摘 | Ivy ME Possenti P Atweh N | 1998 | J Trauma1998，45，3： | 1 |
| 13 | The incidence and risk factors of recurrent venous thromboembolism during pregnancy显示文摘 | P?ivi J. Galambosi Veli-Matti Ulander Risto.J. Kaaja | 2014 | Thrombosis Research2014，，： | 1 |
| 14 | Detection of recurrent cervical cancer by whole-body FDG PET scan in asymptomatic and symp- tomatic women显示文摘 | Unger JB Ivy J J Connor P | 2004 | Gynecol Oncol2004，94，1： | 1 |
| 15 | Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland显示文摘 | Soile Blomqvist P?ivi Klemola Svetlana Kaijalainen Anja Paananen Marja-Leena Simonen Tytti Vuorinen Merja Roivainen | 2010 | Journal of Clinical Virology2010，，1： | 1 |
| 16 | Teaching evidence-based medicine using literature for problem solving显示文摘 | M? tt? nen Merja Tapanainen P? ivi Nuutinen Matti | 2001 | Medical Teacher2001，23，1： | 1 |
| 17 | Formation of PCDDs and PCDFs in municipal waste incineration and its inhibition mechanisms: A review显示文摘 | Kari Tuppurainen Ismo Halonen P?ivi Ruokoj?rvi Juhani Tarhanen Juhani Ruuskanen | 1998 | Chemosphere1998，，7： | 1 |
| 18 | Characterization of a thermophilic sulfur oxidizing enrichment culture dominated by a Sulfolobus sp. obtained from an underground hot spring for use in extreme bioleaching conditions显示文摘 | Virpi L. A. Salo-Zieman Tarja Sivonen Jason J. Plumb Christina M. Haddad Katja Laukkanen P?ivi H. M. Kinnunen Anna H. Kaksonen Peter D. Franzmann Jaakko A. Puhakka | 2006 | Journal of Industrial Microbiology & Biotechnology2006，，12： | 1 |
| 19 | Is there a difference? A prospective study comparing lateral and standard SMAS face lifts with extended SMAS and composite rhytidectomies显示文摘 | IVY E J LORENC Z P ASTON S J | 1996 | Plast Reconstr Surg1996，98，7： | 1 |
| 20 | The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats显示文摘 | Sanna J Paula M P(a)ivi P Raimo KT Liisa A Seppo K | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员