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| 1 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 2 | Dietary intakes of nitrate,nitrite and NDMA in the finish mobile clinic health examination survey显示文摘 | Dich J Jrvinen R Knekt P | 1996 | Food Add Cont1996，13，： | 1 |
| 3 | Antioxidant vitamins and coronary heart disease risk:a pooled analysis of 9 cohorts 1-3显示文摘 | Knekt P Ritz J Pereira MA | 2004 | Am J Clin Nutr2004，80，： | 1 |
| 4 | Dietary antioxidant intake and risk of type 2 diabetes显示文摘 | MONTONEN J KNEKT P JARVINEN R REUNANEN A | 2004 | Diabetes Care2004，27，： | 1 |
| 5 | Diet and breast cancer risk in a cohort of Finnish women 显示文摘 | Jarvinen R Knekt P Seppanen R Teppo L | 1997 | Cancer Letters1997，114，12： | 1 |
| 6 | A biologically important carotenoid for human? 显示文摘 | Jarvinen R Knekt P | 1997 | Cancer Lett1997，114，： | 1 |
| 7 | Vitarmn E and cancer prevention 显示文摘 | Knekt P Aromaa A Maatela J | 1991 | Am J Clin Nutr1991，53，： | 1 |
| 8 | Serum vitamin D and subsequent occurrence of type 2 diabetes显示文摘 | Knekt P Laaksonen M Mattila C | 2008 | Epidemiology2008，19，5： | 1 |
| 9 | Serum antioxidants andrisk of non-insulin dependent diabetes mellitus显示文摘 | Reunanen A Knekt P Aaran RK | 1998 | Eur J Clin Nu-tr1998，52，2： | 1 |
| 10 | Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate,nitrite and nnitroso compounds:a follow-up study显示文摘 | KNEKT P JARVINEN R DICH J | 1999 | International Journal of Cancer1999，80，： | 1 |
| 11 | Tumour markers and screening for gastrointestinal cancer: a follow up study in Finland显示文摘 | Hakama M Stenman UH Knekt P Jarvisalo J Leino A Hakulinen T Maatela J Aromaa A | 1994 | J Med Screen1994，1，1： | 1 |
| 12 | Vitamin D status and the risk of cardiovascular disease death显示文摘 | Kilkkinen A Knekt P Aro A | | 0，，： | 1 |
| 13 | Serum 25-hydroxyvitamin D concentralion and subsequent risk of type 2 dia betes显示文摘 | Mattila C Knekt P Mfiannistii S | | 0，，10： | 1 |
| 14 | Surgical or Nonoperative Treatment for Lumbar Spinal Stenosis?: A Randomized Controlled Trial显示文摘 | Antti Malmivaara P?r Sl?tis Markku Heli?vaara P?ivi Sainio Heikki Kinnunen Jyrki Kankare Nina Dalin-Hirvonen Seppo Seitsalo Arto Herno Pirkko Kortekangas Timo Niinim?ki Hannu R?nty Kaj Tallroth Veli Turunen Paul Knekt Tommi H?rk?nen Heikki Hurri | 2007 | Spine2007，，1： | 1 |
| 15 | Vitamin D statusand the risk of lung cancer: a cohort study in Finland显示文摘 | Kilkkinen A Knekt P Heliovaara M | 2008 | CancerEpidemiol Biomarkers Prev2008，17，11： | 1 |
| 16 | Elevated lung cancer risk among persons with depressed mood 显示文摘 | Knekt P Raitasalo R Heliovaara M | 1996 | Am J Epidemiol1996，144，12： | 1 |
| 17 | Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-Nitroso Compounds: A Follow-up Study 显示文摘 | Paul Knekt Ritva Jarvinen Jan Dich | 1999 | IntJCancer1999，80，6： | 1 |
| 18 | Serum 25-hydroxyvi-tamin D concentration and subsequent risk of type 2 diabetes 显示文摘 | Mattila C Knekt P Mannist S | 2007 | Diabetes Care2007，30，10： | 1 |
| 19 | Serum immunoglobulins and the risk of rheumatoid arthritis显示文摘 | Aho K Heliovaara M Knekt P | 1997 | Ann Rheum Dis1997，56，6： | 1 |
| 20 | Flavonoid intake and risk of chronic diseases显示文摘 | Knekt P Kumpulainen J Jarvinen R | 2002 | Am J Clin Nutr2002，76，3： | 1 |
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