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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 3 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 4 | A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。 | Amy E Monaghan Iain J McEwan | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 7 | Heavy metal distribution in sediment profiles of the Pearl River estuary, South China显示文摘 | Li X D Onyx W H Wai Y S Lia Bma3- J Colesb Michael H Ramseyb Iain Thornton | 2000 | Applied Geochemistry2000，15，5： | 1 |
| 8 | Stimulus-driven and goal-driven control over visual selection显示文摘 | Casimor J H Ludwig Iain D Gilchrist | 2002 | Journal of Experimental Psychology:Human Perception and Performance2002，28，4： | 1 |
| 9 | Neptunium and uranium complexation by hydroxamic acids 显示文摘 | Iain M Robin J T | 1998 | Journal of Alloys and Compounds1998，27，2： | 1 |
| 10 | Molecular pathogenesis of hepatocellular carcinoma显示文摘 | Iain HM Diarmuid MM Xiaoling J | 2006 | Surg Res2006，136，1： | 1 |
| 11 | Effective leadership and decision-making in animal groups on the move显示文摘 | Iain D C Krause J Simon A L | 2005 | Nature2005，433，7025： | 1 |
| 12 | Heavy Metal Contamination of Soils and Plants in the Vicinity of a Lead - Zinc Mine, Korea显示文摘 | Myung C J Iain T | 1995 | Applied Geochemistry1995，11，： | 1 |
| 13 | Momentum and heat transfer in a laminar boundary layer with slip flow显示文摘 | Michael J M Iain D B | 2006 | Journal of Thermophysics and Heat Transfer2006，20，4： | 1 |
| 14 | Collective memory and spafial sorting in animal groups显示文摘 | Iain D C Jens K Richard J | 2002 | Journal of Theory Biology2002，218，： | 1 |
| 15 | Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach显示文摘 | Guennadi A K Iain M P Julian B J | 2004 | Proteome Science2004，，2： | 1 |
| 16 | Analysis of mannose se- lection used for transformation of sugar beet显示文摘 | MORTEN J IAIN D JETTE K | 1998 | Mol Breed1998，4，2： | 1 |
| 17 | Water absorption in a rubber- modified epoxy resin; carboxy terminated butadiene acrylonitrile-amine cured epoxy resin system显示文摘 | IAIN MCEWAN RICHARD A PETHRICK STEPHEN J SHAW | 1999 | Polymer1999，40，： | 1 |
| 18 | Analysis of mechanical systems using interval computations applied to finite element methods 显示文摘 | Dessombz O Thouverez F Iaine J P | 2001 | Journal of Sound and Vibration2001，239，5： | 1 |
| 19 | Quantitative risk assessment of human infection from Escherichia coli 0157 associated with recreational use of animal pasture显示文摘 | NORVAL J C STRACHAN GEOFFEY M DUNN IAIN D OGDEN | 2002 | International Journal of Food Microbiology2002，75，： | 1 |
| 20 | Collective memory and spatial sorting in animal groups显示文摘 | Iain D C Jens K Richard J | 2002 | Journal of Theoretical Biology2002，218，： | 1 |
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