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| 1 | Acute development of collateral circulation and therapeutic prospects in ischemic stroke显示文摘In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic transformation.We have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is achieved.Contrary to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact arteries.We believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein. | Eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota | 2016 | Neural Regeneration Research2016，11，3： | 19 |
| 2 | Histological evaluation for chemotherapeutic responses of metastatic lymph nodes in gastric cancer显示文摘AIM: To investigate the effect of preoperative chemotherapy(pre-CTx) for metastatic lymph nodes(MLNs) of gastric cancer(GC). METHODS: A retrospective cohort of patients with advanced GC, who underwent pre-CTx followed by gastrectomy, was reviewed. The histological tumor regression grade(TRG), which considered the percentage of residual cancer in the visible tumor bed, was applied to primary tumors and individual MLNs: G1a(complete response), G1b(< 10%), G2(10%-50%) and G3(> 50%). The clinical response to pre-CTx was retrospectively evaluated using only MLNs information, and we compared the histological and clinical evaluations of MLNs.RESULTS: Twenty-eight patients were enrolled. A total of 438 MLNs were retrieved, and 22(5%), 48(11%), 63(14%) and 305(70%) LNs were assigned as G1 a, G1 b, G2 and G3, respectively. Stratification of the residual MLNs based on the TRGs was as follows: 28 G1 b MLNs(9%), 48 G2 MLNs(15%), and 253 G3 MLNs(76%) in the D1 region; 20(23%), 15(17%), and 52(60%) in the D2 region, respectively. However, no significant correlation was found between TRGs in MLNs and clinical response in the subgroup for which evaluation of clinical response was available.CONCLUSION: Pre-CTx does not provide any outstanding histological benefit for MLNs, and an appropriate D2 lymphadenectomy should routinely be performed to offer the chance of curative resection. | Osamu Kinoshita Daisuke Ichikawa Yusuke Ichijo Shuhei Komatsu Kazuma Okamoto Mitsuo Kishimoto Akio Yanagisawa Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，48： | 2 |
| 3 | Long‐term outcome of Japanese patients with type 1 autoimmune hepatitis显示文摘 | Kaname Yoshizawa Akihiro Matsumoto Tetsuya Ichijo Takeji Umemura Satoru Joshita Michiharu Komatsu Naoki Tanaka Eiji Tanaka Masao Ota Yoshihiko Katsuyama Kendo Kiyosawa Masanori Abe Morikazu Onji | 2012 | Hepatology2012，，： | 2 |
| 4 | Thioredoxin and protein kinases in redox signaling显示文摘 | Go Fujino Takuya Noguchi Kohsuke Takeda Hidenori Ichijo | 2006 | Seminars in Cancer Biology2006，，6： | 2 |
| 5 | Thermo-responsive polymergels and thermo tropic liquid-crystalline polymergels 显示文摘 | Kishi R Hirasa O Ichijo H | 1995 | Zairyo Kagaku1995，32，2： | 1 |
| 6 | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways 显示文摘 | Nishida E Irie K | 1997 | Science1997，275，5296： | 1 |
| 7 | Physiological roles of ASKI-mediated signal transduction in oxidative stress-and endoplasmic reticulum stress-induced apoptosis : advanced findings from ASKI knockout mice显示文摘 | Matsuzawa A Nishitoh H Tobiume K Takeda K Ichijo H | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 8 | A case of adult mature nephroblastic tumor显示文摘 | Ishibashi K Ichijo S Kameoka H | 1994 | Nippon Hinyokika Gakkai Zasshi1994，85，7： | 1 |
| 9 | Microstructures of (Ti, Cr, Al, Si) N films synthesized bycathodic arc method 显示文摘 | Ichijo K Hasegawa H Suzuki T | 2007 | Surface & Coatings Technology2007，201，： | 1 |
| 10 | Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of preformed oligomer显示文摘 | Tobiume K Saitou M Ichijo H | 2002 | J Cell Physiol2002，191，： | 1 |
| 11 | Survival and apoptosis signals in ER stress: the role of protein kinases 显示文摘 | Kadowaki H Nishitoh H Ichijo H | 2004 | Chem Neuroanat2004，28，： | 1 |
| 12 | Exfoliative cytology of prostatic carcinoma using a prostatic fluid collecting catheter 显示文摘 | Ichijo S Katayose K Koguchi M | 1985 | J Urol1985，133，3： | 1 |
| 13 | Stress-responsive protein kinases in redoxregulated apoptosis signaling显示文摘 | Matsuzawa A Ichijo H | | 0，，： | 1 |
| 14 | Activin receptor-like kinases:a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity显示文摘 | Ten Dijke P Ichijo H Franzén P | | 0，，10： | 1 |
| 15 | I Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways显示文摘 | Ichijo H Nishida E Irie K ten Dijke P Saitoh M Moriguchi T | 1997 | Science1997，275，5296： | 1 |
| 16 | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways显示文摘 | Ichijo H Nishida E Irie K | 1997 | Science1997，275，5296： | 1 |
| 17 | Transforming growth factor β in tissue fibrosis 显示文摘 | Sato H Ichijo H Heldin CH | 1998 | AM J Nephrol1998，18，6： | 1 |
| 18 | In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression显示文摘 | KAMIYAMA M NAGURO I ICHIJO H | 2015 | Cancer Sci2015，106，： | 1 |
| 19 | Hepatocellular carcinoma:recent trends in Japan显示文摘 | Kiyosawa K Umemura T Ichijo T Matsumoto A Yoshizawa K Gad A | | Gastroenterology0，，： | 1 |
| 20 | Significance of development and reversion of collaterals on MRI in early neurologic improvement and long-term functional outcome after intravenous thrombolysis for ischemic stroke显示文摘 | Ichijo M Iwasawa E Numasawa Y | 2015 | AJNR Am J Neuroradiol2015，36，10： | 1 |
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