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| 1 | Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease显示文摘AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) patients.METHODS One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively enrolled.Serum samples were collected at the time of biopsy and ATX was measured by enzyme immunoassays.Sera obtained from 160 healthy,nonobese individuals were used as controls.Histological findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman's test.Diagnostic accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical convenience.RESULTS Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P < 0.001) and correlated significantly with ballooning score and fibrosis stage(r = 0.36,P < 0.001 and r = 0.45,P < 0.001,respectively).Such tendencies were stronger in female patients.There were no remarkable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis scores.The AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective analyses.CONCLUSION Serum ATX levels may at least partially reflect histological severity in NAFLD. | Naoyuki Fujimori Takeji Umemura Takefumi Kimura Naoki Tanaka Ayumi Sugiura Tomoo Yamazaki Satoru Joshita Michiharu Komatsu Yoko Usami Kenji Sano Koji Igarashi Akihiro Matsumoto Eiji Tanaka | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis显示文摘AIM The impact of mild drinking habit(less than 20 g/d of ethanol) on the clinical course of non-alcoholic fatty liver disease(NAFLD) has not been determined. We examined the influence of a mild drinking habit on liver carcinogenesis from NAFLD. METHODS A total of 301 patients who had been diagnosed as having NAFLD by liver biopsy between 2003 and 2016 [median age: 56 years, 45% male, 56% with nonalcoholic steatohepatitis, 26% with advanced fibrosis(F3-4)] were divided into the mild drinking group withe thanol consumption of less than 20 g/d(mild drinking group, n = 93) and the non-drinking group(n = 208). Clinicopathological features at the time of liver biopsy and factors related to hepatocellular carcinoma(HCC) occurrence were compared between the groups.RESULTS We observed significant differences in male prevalence(P = 0.01), platelet count(P = 0.04), and gammaglutamyl transpeptidase(P = 0.02) between the test groups. Over 6 years of observation, the HCC appearance rate was significantly higher in the mild drinking group(6.5% vs 1.4%, P = 0.02). Multivariate survival analysis using Cox's regression model revealed that hepatic advanced fibrosis(F3-4)(P < 0.01, risk ratio: 11.60), diabetes mellitus(P < 0.01, risk ratio: 89.50), and serum triglyceride(P = 0.04, risk ratio: 0.98) were factors significantly related to HCC in all NAFLD patients, while the effect of a drinking habit was marginal(P = 0.07, risk ratio: 4.43). In patients with advanced fibrosis(F3-4), however, a drinking habit(P = 0.04, risk ratio: 4.83), alpha-fetoprotein(P = 0.01, risk ratio: 1.23), and diabetes mellitus(P = 0.03, risk ratio: 12.00) were identified as significant contributors to HCC occurrence. CONCLUSION A mild drinking habit appears to be a risk factor for hepatocarcinogenesis in NAFLD patients, especially those with advanced fibrosis. | Takefumi Kimura Naoki Tanaka Naoyuki Fujimori Ayumi Sugiura Tomoo Yamazaki Satoru Joshita Michiharu Komatsu Takeji Umemura Akihiro Matsumoto Eiji Tanaka | 2018 | World Journal of Gastroenterology2018，24，13： | 6 |
| 3 | Association between endotoxemia and histological features of nonalcoholic fatty liver disease显示文摘AIM To assess whether surrogate biomarkers of endotoxemia were correlated with the histological features ofnonalcoholic fatty liver disease(NAFLD).METHODS One hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide(LPS)-binding protein(LBP) and anti-endotoxin core immunoglobulin G(Endo Cab Ig G) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores. RESULTS Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis(NASH) patients as compared with nonalcoholic fatty liver(NAFL) subjects and was correlated with steatosis(r = 0.38, P < 0.0001) and ballooning scores(r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum Endo Cab Ig G concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between Endo Cab Ig G and histological findings. CONCLUSION LBP/Endo Cab Ig G were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. | Hiroyuki Kitabatake Naoki Tanaka Naoyuki Fujimori Michiharu Komatsu Ayaka Okubo Kyogo Kakegawa Takefumi Kimura Ayumi Sugiura Tomoo Yamazaki Soichiro Shibata Yuki Ichikawa Satoru Joshita Takeji Umemura Akihiro Matsumoto Masayoshi Koinuma Kenji Sano Toshifumi Aoyama Eiji Tanaka | 2017 | World Journal of Gastroenterology2017，23，4： | 5 |
| 4 | Long‐term outcome of Japanese patients with type 1 autoimmune hepatitis显示文摘 | Kaname Yoshizawa Akihiro Matsumoto Tetsuya Ichijo Takeji Umemura Satoru Joshita Michiharu Komatsu Naoki Tanaka Eiji Tanaka Masao Ota Yoshihiko Katsuyama Kendo Kiyosawa Masanori Abe Morikazu Onji | 2012 | Hepatology2012，，： | 2 |
| 5 | Hyperglyce-mia and hemorrhagic transformation of cerebral infarction:a mac-roscopic hemorrhagic transformation rat model显示文摘 | TSUBOKAWA T JOSHITA H SHIOKAWA Y | 2011 | Acta NeurochirSuppl2011，111，2： | 1 |
| 6 | Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm显示文摘 | Matsui T Takuwa Y Joshita H | 1991 | J Cereb Blood Flow Metab1991，11，： | 1 |
| 7 | Changes in the serum level of hepatitis B virus (HBV) surface antigen over the natural course of HBV infection显示文摘 | Akihiro Matsumoto Eiji Tanaka Susumu Morita Kaname Yoshizawa Takeji Umemura Satoru Joshita | 2012 | Journal of Gastroenterology2012，，9： | 1 |
| 8 | Regulation of enzymatic browning of mung bean sprout by heat-shock treatment 显示文摘 | Nishimura M Sameshima N Joshita K | 2012 | Food Science and Technology Research2012，18，3： | 1 |
| 9 | Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease显示文摘 | Tomoko Hatta Yasunari Fujinaga Masumi Kadoya Hitoshi Ueda Hiroaki Murayama Masahiro Kurozumi Kazuhiko Ueda Michiharu Komatsu Tadanobu Nagaya Satoru Joshita Ryo Kodama Eiji Tanaka Tsuyoshi Uehara Kenji Sano Naoki Tanaka | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 10 | Serum levels of interleukin-22 and hepatitis B core-related antigen are associated with treatment response to entecavir therapy in chronic hepatitisB 显示文摘 | Okuhara S Umemura T Joshita S | 2014 | Hepatol Res2014，44，10： | 1 |
| 11 | Human leukocyte antigen class Ⅱ molecules confer both susceptibility and progression in Japa-nese patients with primary biliary cirrhosis 显示文摘 | Umemura T Joshita S Ichijo T | 2012 | Hepatology2012，55，2： | 1 |
| 12 | A case of granulocyte - colony stimulating factor - producing hepatocellular carcinoma con- finned by immunohistochemistry 显示文摘 | Joshita S Nakazawa K Koike S | 2010 | J Korean Med Sci2010，25，3： | 1 |
| 13 | Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors显示文摘 | Shirakawa H Matsumoto A Joshita S | 2008 | Hepatology2008，48，6： | 1 |
| 14 | Hyerglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model 显示文摘 | TSUBOKAWA T JOSHITA H SHIOKAWA Y | 2011 | Acta Neurochir Suppl2011，111，2： | 1 |
| 15 | Hyperglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model 显示文摘 | TSUBOKAWA T JOSHITA H SHIOKAWA Y | 2011 | Aeta Neurochir Supibl2011，111，6： | 1 |
| 16 | Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors显示文摘 | Shirakawa H Matsumoto A Joshita S | 2008 | Hepa- tology2008，48，： | 1 |
| 17 | Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis显示文摘 | Umemura T Joshita S Ichijo T | 2012 | Hepatology2012，55，： | 1 |
| 18 | Down-regulation of SREBP-1c is associated with the development of burned-out NASH显示文摘 | Tadanobu Nagaya Naoki Tanaka Takefumi Suzuki Kenji Sano Akira Horiuchi Michiharu Komatsu Takero Nakajima Tomoko Nishizawa Satoru Joshita Takeji Umemura Tetsuya Ichijo Akihiro Matsumoto Kaname Yoshizawa Jun Nakayama Eiji Tanaka Toshifumi Aoyama | 2010 | Journal of Hepatology2010，，4： | 1 |
| 19 | Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis显示文摘 | Umemura T Joshita S Ichijo T | 2012 | Hepatology2012，55，： | 1 |
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