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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | 小柴胡汤对鼠实验性肝纤维化的影响显示文摘为探讨小柴胡汤对鼠肝纤维化的抑制作用,腹腔分别注射二甲基亚硝基胺和猪血清复制两种肝纤维化动物模型。预防和治疗性投与小柴胡汤可促进肝维生素A含量恢复,降低肝胶原含量和明显抑制肝前α-Ⅰ型胶原的基因表达。同时免疫组化染色证实小柴胡杨可显著减少Ⅰ、Ⅲ型胶原在肝脏沉积和明显减少α-平滑肌原纤维阳性的伊东细胞(ItoCell)的数目。结果显示小柴胡汤可防治鼠肝纤维化的发生与发展。 | 马跃荣 Ichiro Shimizu Susumu Ito Yoko Mizobuchi Mitugi Yasuda Ever Escobar | 1997 | 泸州医学院学报1997，20，2： | 7 |
| 3 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 2 |
| 4 | Gastrointestinal stromal tumor presenting with prominent calcification显示文摘We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism. | Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，39： | 2 |
| 5 | Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis显示文摘 | Shinpei Doi Ichiro Yasuda Tsuyoshi Mukai Takuji Iwashita Shinya Uemura Takahiro Yamauchi Masanori Nakashima Seiji Adachi Masahito Shimizu Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2013 | Journal of Gastroenterology2013，，9： | 2 |
| 6 | Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones显示文摘 | Ichiro Yasuda Naotaka Fujita Hiroyuki Maguchi Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro Tomoko Tada Takeshi Tsujino Yutaka Komatsu | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 7 | Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial显示文摘 | Naotaka Fujita Hiroyuki Maguchi Yutaka Komatsu Ichiro Yasuda Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro | 2003 | Gastrointestinal Endoscopy2003，，2： | 2 |
| 8 | Metallic stents are more efficacious than plastic stents in unresectable malignant hilar biliary strictures: a randomized controlled trial显示文摘 | Tsuyoshi Mukai Ichiro Yasuda Masanori Nakashima Shinpei Doi Takuji Iwashita Keisuke Iwata Tomohiro Kato Eiichi Tomita Hisataka Moriwaki | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，2： | 2 |
| 9 | New fully-covered self-expandable metal stent for endoscopic ultrasonography-guided intervention in infectious walled-off pancreatic necrosis (with video)显示文摘 | Takao Itoi D. Nageshwar Reddy Ichiro Yasuda | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，3： | 2 |
| 10 | Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation显示文摘 | Naoe Goto Ichiro Yasuda Takahiro Uematsu Nobuhiro Kanemura Shinji Takai Kazuki Ando Tomohiro Kato Shinji Osada Hiroshi Takao Shigetoyo Saji Kuniyasu Shimokawa Hisataka Moriwaki | 2001 | Journal of Gastroenterology2001，，12： | 1 |
| 11 | Endoscopic Ultrasound-Guided Antegrade Treatments for Biliary Disorders in Patients with Surgically Altered Anatomy显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Shinya Uemura Masatoshi Mabuchi Mitsuru Okuno Tsuyoshi Mukai Takao Itoi Hisataka Moriwaki | 2013 | Digestive Diseases and Sciences2013，，8： | 1 |
| 12 | The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis显示文摘 | Takao Itoi Terumi Kamisawa Yoshinori Igarashi Hiroshi Kawakami Ichiro Yasuda Fumihide Itokawa Yuui Kishimoto Masaki Kuwatani Shinpei Doi Seiichi Hara Fuminori Moriyasu Todd H. Baron | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 13 | Distribution of unsaturated aliphatic acid amides in Japanese Zanthoxylum species显示文摘 | Ichiro Yasuda Koichi Yakeya Hideji Itokawa | | 0，，06： | 1 |
| 14 | Multicenter retrospective study of endoscopic ultrasound‐guided biliary drainage for malignant biliary obstruction in J apan显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Hironari Kato Takao Itoi Hiroshi Kawakami Keiji Hanada Hirotoshi Ishiwatari Ichiro Yasuda Hirofumi Kawamoto Fumihide Itokawa Masaki Kuwatani Tomohiro Iiboshi Tsuyoshi Hayashi Shinpei Doi Yousuke Nakai | 2014 | J Hepatobiliary Pancreat Sci2014，，5： | 1 |
| 15 | EUS-guided rendezvous for difficult biliary cannulation using a standardized algorithm: a multicenter prospective pilot study (with videos)显示文摘 | Takuji Iwashita Ichiro Yasuda Tsuyoshi Mukai Keisuke Iwata Nobuhiro Ando Shinpei Doi Masanori Nakashima Shinya Uemura Masatoshi Mabuchi Masahito Shimizu | 2015 | Gastrointestinal Endoscopy2015，，： | 1 |
| 16 | Tumor nec- rosis factor-a promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells显示文摘 | Yosuke Osawa Masato Hoshi Ichiro Yasuda | 2013 | PLoS One2013，8，65： | 1 |
| 17 | Distribution of unsaturated aliphatic acid amides in Japanese Zanthoxylum species显示文摘 | Ichiro Yasuda Koichi Takeya | 1982 | Phytochemistry1982，21，6： | 1 |
| 18 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 1 |
| 19 | Endoscopic ultrasound-guided biliary drainage: a review显示文摘 | Takuji Iwashita Shinpei Doi Ichiro Yasuda | 2014 | Clinical Journal of Gastroenterology2014，，： | 1 |
| 20 | Diaryheptanoids from the Rhizomes of Curcuma xanthorrhi-za and Alpinia officinarum显示文摘 | Shin-Ichi Uehara Ichiro Yasuda Kazuyuki Akiyama | 1987 | Chem Pharm Bull1987，35，8： | 1 |
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