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| 1 | Does heart rate variability correlate with long-term prognosis in myocardial infarction patients treated by early revascularization?显示文摘AIM To assess the prevalence of depressed heart rate variability(HRV) after an acute myocardial infarction(MI),and to evaluate its prognostic significance in the present era of immediate reperfusion.METHODS Time-domain HRV(obtained from 24-h Holter recordings) was assessed in 326 patients(63.5 ± 12.1 years old; 80% males),two weeks after a complicated MI treated by early reperfusion: 208 ST-elevation myocardial infarction(STEMI) patients(in which reperfusion wassuccessfully obtained within 6 h of symptoms in 94% of cases) and 118 non-ST-elevation myocardial infarction(NSTEMI) patients(percutaneous coronary intervention was performed within 24 h and successful in 73% of cases). Follow-up of the patients was performed via telephone interviews a median of 25 mo after the index event(95%CI of the mean 23.3-28.0). Primary endpoint was occurrence of all-cause or cardiac death; secondary end-point was occurrence of major clinical events(MCE,defined as mortality or readmission for new MI,new revascularization,episodes of heart failure or stroke). Possible correlations between HRV parameters(mainly the standard deviation of all normal RR intervals,SDNN),clinical features(age,sex,type of MI,history of diabetes,left ventricle ejection fraction),angiographic characteristics(number of coronary arteries with critical stenoses,success and completeness of revascularization) and long-term outcomes were analysed.RESULTS Markedly depressed HRV parameters were present in a relatively small percentage of patients: SDNN < 70 ms was found in 16% and SDNN < 50 ms in 4% of cases. No significant differences were present between STEMI and NSTEMI cases as regards to their distribution among quartiles of SDNN(χ~2 =1.536,P = 0.674). Female sex and history of diabetes maintained a significant correlation with lower values of SDNN at multivariate Cox regression analysis(respectively: P = 0.008 and P = 0.008),while no correlation was found between depressed SDNN and history of previous MI(P = 0.999) or number of diseased coronary arteries(P = 0.428) or unsuccessful percutaneous coronary intervention(PCI)(P = 0.691). Patients with left ventricle ejection fraction(LVEF) < 40% presented more often SDNN values in the lowest quartile(P < 0.001). After > 2 years from infarction,a total of 10 patients(3.1%) were lost to follow-up. Overall incidence of MCE at follow-up was similar between STEMI and NSTEMI(P = 0.141),although all-cause and cardiac mortality were higher among NSTEMI cases(respectively: 14% vs 2%,P = 0.001; and 10% vs 1.5%,P = 0.001). The Kaplan-Meier survival curves for all-cause mortality and for cardiac deaths did not reveal significant differences between patients with SDNN in the lowest quartile and other quartiles of SDNN(respectively: P = 0.137 and P = 0.527). Also the MCE-free survival curves were similar between the group of patients with SDNN in the lowest quartile vs the patients of the other SDNN quartiles(P = 0.540),with no difference for STEMI(P = 0.180) or NSTEMI patients(P = 0.541). By the contrary,eventsfree survival was worse if patients presented with LVEF < 40%(P = 0.001).CONCLUSION In our group of patients with a recent complicated MI,abnormal autonomic parameters have been found with a prevalence that was similar for STEMI and NSTEMI cases,and substantially unchanged in comparison to what reported in the pre-primary-PCI era. Long-term outcomes did not correlate with level of depression ofHRV parameters recorded in the subacute phase of the disease,both in STEMI and in NSTEMI patients. These results support lack of prognostic significance of traditional HRV parameters when immediate coronary reperfusion is utilised. | Leonida Compostella Nenad Lakusic Caterina Compostella Li Van Stella Truong Sabino Iliceto Fabio Bellotto | 2017 | World Journal of Cardiology2017，9，1： | 9 |
| 2 | Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications显示文摘Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data. | Alessandra Vecchiati Sara Tellatin Annalisa Angelini Sabino Iliceto Francesco Tona | 2014 | World Journal of Transplantation2014，4，2： | 3 |
| 3 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 4 | Dynamic Equivalents of Asynchronous Motor Loads in System Stability Studies显示文摘 | Iliceto F Capasso A | 1974 | IEEE Trans on PAS1974，93，： | 1 |
| 5 | Plasma homocysteine levels in Ldopa-treated Parkinson's disease patients with cognitive dysfunctions显示文摘 | Zoccolella S Lamberti P Iliceto G | 2005 | Clin Chem Lab Med2005，43，10： | 1 |
| 6 | Myocardial contrast echocardiography in the evaluation of viable myocarioum after acute myocardial infarction显示文摘 | Iliceto S | 1998 | Am J Cardiol1998，81，： | 1 |
| 7 | Dynamic equivalents of asynchronous motor loads in system stability studies显示文摘 | Iliceto Francesco Capasso Alfonso | 1974 | IEEE Trans on Power Apparatus and Systems1974，93，5： | 1 |
| 8 | Detection of proximal stenosis of left coronary artery by digital transesophageal echocardiography: feasibility, sensitivity, and specificity显示文摘 | MEMMOLA C ILICETO S RIZZON P | 1993 | J Am Soc Eehocardiogr1993，6，2： | 1 |
| 9 | Occupational stress and psychopathology in health professionals:an explorative study with the multiple indicators multiple causes(MIMIC)model approach显示文摘 | Iliceto P Pompili M Spencer-Thomas S | 2013 | Stress2013，16，2： | 1 |
| 10 | Effects of L- carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) trial显示文摘 | Iliceto S Scrutinio D Bruzzi P | 1995 | J Am Coll Cardiol1995，26，2： | 1 |
| 11 | Electrocardiographic Predictors of Electroanatomic Scar Size in Arrhythmogenic Right Ventricular Cardiomyopathy: Implications for Arrhythmic Risk Stratification显示文摘 | ALESSANDRO ZORZI FEDERICO MIGLIORE MOHAMED ELMAGHAWRY MARIA SILVANO MARTINA PERAZZOLO MARRA ALICE NIERO KIM NGUYEN ILARIA RIGATO BARBARA BAUCE CRISTINA BASSO GAETANO THIENE SABINO ILICETO DOMENICO CORRADO | 2013 | J Cardiovasc Electrophysiol2013，，12： | 1 |
| 12 | Compound and Digenic Heterozygosity Predicts Lifetime Arrhythmic Outcome and Sudden Cardiac Death in Desmosomal Gene–Related Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Ilaria Rigato Barbara Bauce Alessandra Rampazzo Alessandro Zorzi Kalliopi Pilichou Elisa Mazzotti Federico Migliore Martina Perazzolo Marra Alessandra Lorenzon Marzia De Bortoli Martina Calore Andrea Nava Luciano Daliento Dario Gregori Sabino Iliceto Gaet | 2013 | Circulation: Cardiovascular Genetics2013，，6： | 1 |
| 13 | Myocardial contrast echocardiography in the evalua- tion of viable myocardium after acute myocardial infarction 显示文摘 | Galiuto L Iliceto S | 1998 | Am J Cardiol1998，81，12： | 1 |
| 14 | Myocardial infarction and left ventricular remodeling: results of the CED IM trial 显示文摘 | Colonna P Iliceto S | 2000 | Am Heart J2000，139，2： | 1 |
| 15 | Atypical (mid-ventricular) Takotsubo syndrome in a survival of out-of-hospital ventricular fibrillation: Cause or consequence?显示文摘 | Nicola Gasparetto Alessandro Zorzi Martina Perazzolo Marra Federico Migliore Massimo Napodano Domenico Corrado Sabino Iliceto Luisa Cacciavillani | 2013 | International Journal of Cardiology2013，，： | 1 |
| 16 | Kinetics of the thiol-disulfide exchange显示文摘 | Fava A Iliceto A Camera E | 1957 | J Am Chem Soc1957，79，4： | 1 |
| 17 | Analysis of half-wave length transmission lines with simulation of corona losses显示文摘 | Iliceto F Cinieri E | 1988 | IEEE Trans on Power Delivery1988，3，4： | 1 |
| 18 | Electrocardiographic J waves as a hyperacute sign of Takotsubo syndrome显示文摘 | Alessandro Zorzi Federico Migliore Martina Perazzolo Marra Giuseppe Tarantini Sabino Iliceto Domenico Corrado | 2012 | Journal of Electrocardiology2012，，4： | 1 |
| 19 | New trends in anticoagulant therapy显示文摘 | Pengo V Pegoraro C Iliceto S | 2004 | Is Med Assoc J2004，6，8： | 1 |
| 20 | Myocardial edema underlies dynamic T-wave inversion (Wellens’ ECG pattern) in patients with reversible left ventricular dysfunction显示文摘 | Federico Migliore Alessandro Zorzi Martina Perazzolo Marra Cristina Basso Francesco Corbetti Manuel De Lazzari Giuseppe Tarantini Paolo Buja Carmelo Lacognata Gaetano Thiene Domenico Corrado Sabino Iliceto | 2011 | Heart Rhythm2011，，： | 1 |
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