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| 1 | 秦岭环斑结构花岗岩中暗色包体的岩浆混合成因及岩石学意义——元素和Nd、Sr同位素地球化学证据显示文摘秦岭环斑结构花岗岩中的暗色包体主要为闪长质岩浆包体,SiO2(50%-62%)低,K2O+Na2O(7.01%-9.4%) 高,里特曼指数(δ)为5-9,F、过渡性元素和稀土元素富集。包体和寄主岩石的主要氧化物之间具有良好的线性关系、稀土配分曲线和微量元素配分曲线相似,以及活动性组分、高场强元素、轻稀土和同位素特征等显示,寄主岩石和包体之间发生过明显的成分交换,这些成分在二者中大体上趋于平衡。这种特征表明,环斑结构花岗岩岩浆的形成至少与两种岩浆的混合有关。包体的(87Sr/86Sr)i较低(0.70514-0.70624)、εNd(t)值较高(-0.95--3.3)和富过渡性元素的特征揭示,形成包体的原始岩浆为起源于幔源的玄武质岩浆。包体和寄主岩石的关系显示岩浆的混合方式为基性岩浆注入到已经开始结晶的酸性岩浆。这些研究为环斑结构花岗岩是起源于地壳的酸性岩浆和起源于地幔的基性岩浆形成的混合岩浆结晶的产物提供了新证据;同时,也为环斑结构的混合成因研究提供了新思路和途径。 | 王晓霞 王涛 Ilmari Happala 卢欣祥 | 2005 | 岩石学报2005，21，3： | 61 |
| 2 | Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection显示文摘AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing H.pylori infection,eight showed H.pylori antibodies by immunoblotting.All eight had elevated PCA and 4/8 also had IF antibodies.Of the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in four.Among the patients with low to moderate grade atrophic gastritis(all except one with an ongoing H.pylori infection),serum markers for gastric atrophy and autoimmunity were seldom detected.However,one H.pylori negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of H.pylori infection in autoimmune gastritis,and positive autoimmune serum markers in H.pylori gastritis suggest an etiological role for H.pylori in autoimmune gastritis. | Lea Irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin | 2010 | World Journal of Gastroenterology2010，16，1： | 10 |
| 3 | Clinically relevant human temporal bone measurements using novel high-resolution cone-beam CT显示文摘Objective: To test the feasibility of measuring fine temporal bone structures using a newly established cone-beam computed tomography(CBCT)system.Materials and methods: Six formalin-fixed human cadaver temporal bones were imaged using a high-resolution CBCT system that has 900 frames and copper t aluminum filtration. Fine temporal bone structures, including those of the facial nerve canal and vestibular structures, were identified and measured.Results: The fine structures of the middle ear, including the tympanic membrane, tendon of the tensor tympani, cochleariform process of the semicanal of the tensor tympani, pyramidal eminence, footplate of the stapes, full path of the facial nerve within the temporal bone, supralabyrinthine space, semicircular canals, pathway of the subarcuate canal, and full path of the vestibular aqueduct, were clearly demonstrated. The vestibular aqueduct has a midpoint width of 0.4 ± 0.0 mm and opercular width of 0.5 ± 0.1 mm(mean ± SD). The length of the internal acoustic meatus was 10.6 ± 1.2 mm(mean ± SD), and the diameter of the internal acoustic meatus was 3.7 ± 0.3 mm(mean ± SD).Conclusion: This novel high-resolution CBCT system has potentially broad applications in the diagnosis of inner ear disease and in monitoring associated pathological changes, surgical planning, navigation for the ear surgery, and temporal bone training. | Jing Zou Jaakko Laahelma Antti Arnisalo Ilmari Pyykko | 2017 | Journal of Otology2017，12，1： | 10 |
| 4 | Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy显示文摘Objective:The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy(CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Materials and methods:Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy,two-photon excited fluorescence(TPEF) microscopy,and the second harmonic generation(SHG) microscopy.Results:In cholesteatoma tissues from the mastoid,a strong resonant signal at 2845 cm^(-1) was observed by CARS,which indicated the detection of the CH_2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm^(-1) suggestive of CH_3 bonds in amino acids.A strong resonant signal at 2940 cm^(-1) appeared in an area of the same specimen,which also generated abundant signals by TPEF and SHG microscopy at 817 nm,which was suggestive of collagen.In the tympanic membrane specimen with cholesteatoma,a strong resonant signal with corrugated morphology was detected,which indicated the presence of lipids.A strong signal was detected in the tympanic membrane with chronic otitis media using TPEF/SHG at 817 nm,which indicated collagen enrichment.The CARS and TPEF/SHG images were in accordance with the histology results.Conclusion:These results suggest the need to develop a novel CARS microendoscope that can be used in combination with TPEF/SHG to distinguish cholesteatoma from inflammatory tissues. | Jing Zou Antti Isomaki Timo Hirvonen Antti Aarnisalo Jussi Jero Ilmari Pyykko | 2016 | Journal of Otology2016，11，3： | 4 |
| 5 | 用MRI体内观测钥孔嘁血蓝素中耳免疫诱导的内淋巴积水的初步探讨显示文摘目的用磁共振成像方法研究中耳免疫反应诱导的动物内淋巴积水。方法将9只豚鼠分为2组,中耳免疫组(4只)和磷酸盐缓冲液(Phosphate buffered saline,PBS)对照组(5只)。先用KLH加福氏完全佐剂行四肢趾蹼免疫,2周后将KLH投放至中耳进行局部免疫。另外5只豚鼠中耳放置PBS作为对照组。用gadolinium增强的磁共振成像观察内耳淋巴液的动态变化,用耳蜗电图评估听功能改变。结果在KLH中耳免疫的动物中,2只发生内淋巴积水,3只血迷路屏障通透性增加,2只听力损失大于10dB。结论磁共振成像可以显示KLH中耳免疫反应的耳蜗改变,内淋巴积水和血迷路屏障通透性的增加提示存在着一个“漏的迷路”,将有可能为内耳疾病的诊断提供更加精确的依据。 | 邹静 Ilmari PYYKK Brje BJELKE | 2005 | 中华耳科学杂志2005，3，3： | 4 |
| 6 | 内淋巴囊手术治疗梅尼埃病与剪切应激反应显示文摘梅尼埃病是以眩晕、波动性听力减退、耳鸣和耳闷涨感为特征的症状符合体,明显影响患者的生活质量和工作能力。 | 邹静 Ilmari Pyykkto | 2012 | 中华耳科学杂志2012，10，2： | 4 |
| 7 | 线粒体毒素诱导伴有眩晕的突发性耳聋模型的建立显示文摘目的建立一个突发性感音神经性耳聋(SSNHL)的动物模型,以研究其发病机制和治疗方法。方法49只雄性豚鼠根据给药浓度和听性脑干反应(ABR)测试时间分为7组,用浸有0.3、0.5 mol/L3-硝基丙酸(3-NP)或磷酸盐缓冲液(PBS)的明胶海绵分别放置于豚鼠左耳圆窗龛,作用30 min后取出。4%多聚甲醛加1%戊二醛行活体心脏灌注固定,耳蜗JB4包埋、切片后做光镜观察。结果所有暴露于3-NP的动物均表现中、重度听力减退至ABR反应消失。高剂量(0.5 mol/L 3-NP)组动物均出现快相指向健侧的自发性眼震和不同程度的姿势失衡等单侧前庭功能损伤的典型症状;低剂量(0.3 mol/L3-NP)组仅1只动物出现自发性眼震,2只动物出现姿势失衡。前庭症状在暴露后2 d内消失。所有实验组动物柯蒂氏器和支持细胞出现一过性水肿。暴露后12 h,螺旋神经节细胞胞浆和胞核内有空泡形成,第7天螺旋神经节细胞变性。结论经圆窗膜投放3-NP至内耳可以复制出SSNHL的临床症状,螺旋神经节细胞损伤是其最明显的病理改变。 | 张亚 邹静 Ilmari Pyykko 吴皓 | 2007 | 上海交通大学学报(医学版)2007，27，1： | 4 |
| 8 | 豚鼠外源性血管内皮细胞生长因子增强内耳屏障转运作用的磁共振成像研究显示文摘目的观察血管内皮细胞生长因子(vascularendothelialgrowthfactor, VEGF)能否改变血迷路屏障和血外淋巴屏障的物质转运作用。方法11只300 ~900g雌雄兼并的杂色豚鼠在甲苯噻嗪(16mg/kg)和氯氨酮(60mg/kg)基础麻醉下接受手术,通过圆窗膜(明胶海绵吸附)将VEGF(6耳)或磷酸盐缓冲液(PBS, 5耳)投放至内耳。用T1对比剂二乙烯三胺五乙酸双甲酰胺钆(gadolinium diethylenetriamine pentaacetate bismethylamide, Gd DTPA BMA)作为内耳屏障转运示踪剂,用4 7T场强, 40cm孔径的BrukerBiospecAvance47 /40试验磁共振系统进行豚鼠耳蜗二维磁共振成像观测,用Paravision软件进行图像密度分析,用AdobePhotoshop6 0软件进行图像呈示。结果圆窗膜投放PBS未影响血外淋巴屏障渗透性变化。圆窗膜投放VEGF可显著增强处理侧血外淋巴屏障渗透性,VEGF处理的耳蜗鼓阶内Gd DTPA BMA转运显著增加(P<0 01 ), VEGF处理的耳蜗前庭阶内Gd DTPA BMA转运也显著增加(P<0 01)。VEGF处理的耳蜗中阶内Gd DTPA BMA转运无明显增加(P>0 05)。结论VEGF显著增强血外淋巴屏障的物质转运作用并可能有利于内耳在各种有害环境下的代偿及修复。 | 邹静 Pyykko Ilmari Bjelke Borje Counter S Allen | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，4： | 3 |
| 9 | 鼓室内注射药物治疗梅尼埃病国际专家共识(全译文)显示文摘目的:鼓室内(intratympanic,IT)注射药物治疗梅尼埃病(MD)因其疗效显著而备受关注。由于IT注射药物治疗MD的共识和新证据的发布,对IT注射药物治疗MD进行细节上的补充具有重要意义。方法:检索近二十年来有关IT注射药物治疗MD的文献,参考《梅尼埃病治疗国际共识(ICON)》(2018年),《美国梅尼埃病临床实践指南》(2020年)和《梅尼埃病诊断治疗的欧洲立场声明》(2018),并遵循来自欧洲、美国和中国的专家意见。结果:专家一致认为:①鼓室内注射甲泼尼龙(ITM)对眩晕控制的疗效优于鼓室内注射地塞米松(ITD),ITM有恢复MD患者听力的可能性。②由于氨基糖甙类药物的耳毒性,鼓室内注射庆大霉素(ITG)在听力良好MD患者中的应用持谨慎态度。但也有研究表明,小剂量ITG对听力没有显著影响,还需要高水平证据的临床研究进一步证明。③目前普遍接受的ITG治疗终点是在12个月内无眩晕发作或受累耳客观检查提示前庭功能丧失。结论:对IT注射药物治疗MD的药物类型、疗效和治疗终点还需要更多高证据水平的研究进行评价。 | 李姝娜 Ilmari Pyykkö 张青 杨军 段茂利 | 2022 | 临床耳鼻咽喉头颈外科杂志2022，36，7： | 2 |
| 10 | Dexamethasone does not affect endolymphatic hydrops(EH)in patients with Meniere's disease within 24 h,and intratympanic administration of gadolinium plus dexamethasone simplifies high-quality imaging of EH using a novel protocol of 7 min显示文摘Background:Intratympanic administration of gadolinium chelate allows for a better visualization of endolymphatic hydrops(EH)using MRI than intravenous injection and was recently further improved to facilitate high-quality imaging of EH in 7 min.The aim of the present study was to simplify the intratympanic administration protocol by mixing gadolinium chelate with therapeutic dexamethasone and to evaluate the effects of this mixture on the visualization of EH in MRI.Materials and methods:In an in vitro study,the potential impact of gadolinium-diethylenetriamine pentaacetic acid(Gd-DTPA)on the stability of dexamethasone was evaluated by analyzing dynamic changes in dexamethasone with high-performance liquid chromatography(HPLC)after mixing with GdDTPA.Ten patients with definite Meniere's disease(MD)were recruited to study the potential interference of dexamethasone on MRI visualization of EH,and 49 patients with MD were recruited to evaluate the effect of intratympanic injection of Gd-DTPA mixed with dexamethasone on MRI of EH using a 3T MR machine and a novel heavily T2-weighted 3-dimensional fluid-attenuated inversion recovery reconstructed using a magnitude plus zero-filled interpolation(hT2FLAIR-MZFI)sequence.Results:The retention times and peak area of dexamethasone in HPLC were not modified by the addition of Gd-DTPA.EH grading in the cochlea and vestibule was not influenced in any ear by intratympanic injection of dexamethasone.Excellent inner ear images were obtained from all patients,and EHs with various grades were displayed.There were significant correlations between diagnosis and cochlear EH(p<0.01,Spearman's Rho),between diagnosis and vestibular EH(p<0.01,Spearman's Rho),and between cochlear and vestibular EH(p<0.01,Spearman's Rho).The distribution of Gd-DTPA plus dexamethasone negatively correlated with the grade of vestibular EH.Injury of the endolymph-perilymph barrier was detected in one cochlea and three vestibules of 59 inner ears with MD.Conclusions:Intratympanic administration of Gd-DTPA plus dexamethasone yielded high-quality MRI images of EH in patients with MD using a novel 7-min protocol and simplified the clinical application.Intratympanic administration of Gd-DTPA plus dexamethasone might be used to test its therapeutic effect in future work. | Jing Zou Zikai Zhao Hongbin Li Guoping Zhang Qing Zhang Jianping Lu Ilmari Pyykko | 2022 | Journal of Otology2022，17，3： | 2 |
| 11 | The Foundations of Jurgen Habennas's Di course Ethics 显示文摘 | Jari Ilmari Niemi | 2008 | The Journal of Value Inquiry2008，，42： | 1 |
| 12 | 耳蜗振动创伤后血迷路屏障变化的磁共振成像表现显示文摘目的在动物模型中探讨电钻振动诱导听力减退的机制和可能的血迷路屏障变化。方法用电磁振荡器在5只豚鼠听泡上产生可重复的振动,其振动频率为250 Hz,用复合动作电位评估其听功能,振动后3小时至4 天用4.7特斯拉磁共振成像分析其血迷路屏障变化。静脉注射T1增强剂Gadolinium-diethylenetriaminepentaacetate- bismethylamide(Gd-DTPA-BMA)作为血迷路屏障的示踪剂。结果振动诱导平均听力损失40 dB HL,在振动后立即测试的耳蜗中,其中阶摄取Gd-DTPA-BMA,提示血迷路屏障通透性增加。在振动后2天至4天的动物中,其中阶内无Gd-DTPA-BMA摄取。结论 250 Hz振动使血路屏障通透性增加是使导致听力减退的原因之一。其通透性的变化为一个可逆的过程。 | 邹静 Ilmari Pyykk Pivi Sutinen Esko Toppila | 2006 | 中华耳科学杂志2006，4，1： | 1 |
| 13 | An Animal Model of Sudden Onset Sensorineural Hearing Loss with Vestibular Function Disturbances Induced By Mitochondrial Toxin显示文摘Objective To establish an animal model of sudden onset sensorineural hearing loss (SSNHL) to study its mechanisms. Materials and methods The inner ear was exposed to 3-nitropropionic acid at 0.5 mol/L (3-NP (H)) and 0.3 mol/L (3-NP (L)) through the round window membrane for 30 minutes in 50 male guinea pigs. Thresholds of auditory brainstem responses(ABR) were established before the treatment and retested at 4 hours, 1 day, 3 days and 6 days following 3-NP exposure. Control animals were treated with phosphate buffered saline (PBS) and their ABRs were retested at 4 hours and 1 day after the treatment. Animals were monitored for nystagmus and postural signs of vestibular dysfunction, using a digital video camera, following the treatment procedure. Specimens were taken at 12 hours, 1 day, 3 days and 7 days following 3-NP(H) exposure and embedded in JB4 for light microscopy observation. Results ABRs were lost in all animals tested at 4 hours following 3-NP (H) exposure. The rate of complete ABR loss decreased as post-treatment test time increased. ABRs were lost in 80% (4/5) of the animals at 1 day after exposure to 3-NP (L). Spontaneous horizontal nystagmus with a fast phase away from the treated ear developed in all 3-NP (H)-treated animals and in 20 % ( 1/5) of the animals exposed to 3-NP (L), except for the one treated bilaterally. Various degree of postural disturbances consistent with unilateral vestibular dysfunction, such as spontaneous barrel rolling towards the exposure side while walking, were seen in all animals exposed to 3-NP(H) and 40% (2/5) of animals exposed to 3-NP(L), except for the one animal treated bilaterally, which showed no signs of imbalance. Both nystagmus and postural disturbances resolved in 2 days following 3-NP exposure. Histological study showed temporary edema tin the organ or Corti, Claudius cells and the inner sulcus cells 3 days after 3-NP (H) treatment. Enlargement of intercellular space in the spiral prominence was first noticed at 12 hours post-3-NP (H) exposure, progressed at day 3 and recovered at day 7. Vacuoles in the cellular plasm and nucleus was seen as early as at 12 hours post-3-NP exposure in the spiral ganglion cells, and signs of degeneration were visible at day 7. Conclusion Inner ear exposure to 3-NP through the round window membrane appears to reproduce clinic manifestations and may serve as a legitimate animal model of | PYYKK Ilmari | 2006 | Journal of Otology2006，1，2： | 1 |
| 14 | Vertigo and imbalance in children:a retrospective study in a Helsinki University otorhinolaryngology clinic显示文摘 | Riina N Ilmari P Kentala E | 2005 | Arch Otolaryngol Head Neck Surg2005，131，11： | 1 |
| 15 | In Vivo Observation of Dynamic Perilymph Formation Using 4.7 T MRI with Gadolinium as a Tracer显示文摘 | Jing Zou Ilmari Pyykk? S. Allen Counter Tomas Klason Poul Bretlau B? rje Bjelke | 2003 | Acta Oto-Laryngologica2003，，8： | 1 |
| 16 | Vertigo and imbalance in children: a retrospective study in a Helsinki University otorhinolaryngology clinic显示文摘 | RIINA N ILMARI P KENTALA E | 2005 | Arch Otolaryngol Head Neck Surg2005，131，： | 1 |
| 17 | Petrography and Geochemistry of the Eurajoki Stock,A Rapakivi-granite Complex with Greisen-Type Mineralization in Southwestern Finland显示文摘 | | 1977 | Geological survey of Finland1977，286，： | 1 |
| 18 | Mitochondria toxin-induced acute cochlear cell death indicates cellular activity-correlated energy consumption显示文摘 | Jing Zou Ya Zhang Weikai Zhang Dennis Poe Suoqiang Zhai Shiming Yang Ilmari Pyykk? | 2013 | European Archives of Oto-Rhino-Laryngology2013，，9： | 1 |
| 19 | Enhanced oval window and blocked round window passages for middle inner ear transportation of gadolinium in guinea pigs with a perforated round window membrane 显示文摘 | Jing Zou Ilmari Pyykk | 2013 | European Archives of Oto - Rhino - Laryngology2013，，11： | 1 |
| 20 | Oval Window Transport of Gd-DOTA From Rat Middle Ear to Vestibulum and Scala Vestibuli Visualized by In Vivo Magnetic Resonance Imaging显示文摘 | Zou Jing Poe Dennis Ramadan Usama Abo Pyykk? Ilmari | 2012 | EN2012，，2： | 1 |
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