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| 1 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 2 | Naturalistic pharmacogenetic study of treatment resistance to typical neuroleptics in European–Brazilian schizophrenics显示文摘 | Fabiana B. Kohlrausch Clarissa S. Gama Maria Inês Lobato Paulo Belmonte-de-Abreu Sidia M. Callegari-Jacques Alejandro Gesteira Francisco Barros ángel Carracedo Mara H. Hutz | 2008 | Pharmacogenetics and Genomics2008，，7： | 1 |
| 3 | On the urban heat island effect dependence on temperature trends显示文摘 | Ines Camilloni Vicente Barros | 1997 | Climatic Change1997，37，： | 1 |
| 4 | open suction system显示文摘 | Zeitoun SS de Barros AL Diccini SA prospective randomized study of ventilation-associated pneumonia in patients using a closed vs | 2003 | Journal of Clinical Nursing2003，12，4： | 1 |
| 5 | Transgene integration and chromosome alterations in two transgenic lines of tritordeum显示文摘 | BARRO F MART IN A CABRERA A | 2003 | Chromosome Research2003，11，6： | 1 |
| 6 | Characteristics of Intestinal Habits in Children Younger Than 4 Years: Detecting Constipation显示文摘 | Denise M. Mota Aluisio J.D. Barros Iná Santos Alícia Matijasevich | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，4： | 1 |
| 7 | Emergy evaluation and economic performance of banana cropping systems in Guadeloupe (French West Indies)显示文摘 | Inácio de Barros Jean Marc Blazy Geraldo Stachetti Rodrigues Regis Tournebize Jean Pierre Cinna | 2008 | Agriculture, Ecosystems and Environment2008，，4： | 1 |
| 8 | Short-term effect of physical activity on sleep health:A population-based study using accelerometry显示文摘Background:Regular physical activity(PA) is an important behavior in improving sleep health.However,the short-term effects of PA on sleep are still controversial.This study aimed to verify the effect of different intensities of PA practiced in different periods of the day on the subsequent sleep night in a population-based cohort of young adults.Methods::Prospective analyses were conducted for PA performed during the day and its effect on the following sleep night using data from the22-year follow-up of the 1993 Pelotas Birth Cohort in Brazil(mean age of participants-22.6 years).Wrist-worn accelerometry was usedto measure both PA and sleep parameters.Regarding intensity,we analyzed the sleep effect of light PA(LPA),moderate PA,and vigorous PA,stratified by sex.Sleep variables were sleep time window(STW;the difference between sleep onset and sleep end),total sleep time(TST;the sum of minutes classified as sleep in STW),and sleep percent(SP;SP=(TST/STW);expressed in percentage).We performed generalized estimating equations using Stata software.Results::The means of STW,TST,and SP were 443.6 min/day,371.1 min/day,and 84%,respectively.Time spent in moderate PA and vigorous PA in the morning and afternoon was not associated with sleep variables.Among men,10 min/day of morning LPA increased TST by2.56 min/day.Among women,10 min/day of morning LPA increased SP by 0.15 percentage points.Afternoon LPA also increased SP by 0.09 percentage points for women.Night PA seems to have an inverse effect on sleep variables for any intensity and both sexes.Conclusion::The effect of PA on sleep health is intrinsically related to the period of the day in which it is performed.The effect magnitude is different between sexes.For better sleep health,it is preferable that PA be performed during the day. | Andrea Wendt Inácio Crochemore M.da Silva Helen Goncalves Ana Menezes Fernando Barros Fernando C.Wehrmeister | 2022 | Journal of Sport and Health Science2022，11，5： | 0 |
| 9 | Natural Ageing Tests to Study In-service Different Facade Solutions--ETICS and Premixed One-Coat Rendered Walls显示文摘 | Luis Silva Ines Flores-Colen Nuno Vieira Ana Barros Timmons | 2016 | Journal of Civil Engineering and Architecture2016，10，6： | 0 |
| 10 | 瑞吉欧学校显示文摘瑞吉欧学校(Reggio School)的设计理念是通过建筑环境来激发孩子们的探索和求知欲。因此,该建筑被视作一个复杂的生态系统,让孩子们在通过自我驱动的集体实验过程中引导自身教育,这也遵循了罗里斯·马拉古奇(Loris Malaguzzi)和意大利吉欧·艾米利亚市当地家长共同提出的教育理念,旨在增强孩子们应对不可预测挑战和潜在风险的能力。从该建筑的设计、建造到使用,都旨在超越可持续的范式,并将生态作为一种路径,继而将环境影响、多种群类别、物质动态化、集体治理以及教学方法通过建筑相交汇。 | Andrés Jaque Roberto Gonzalez Garcia Luis Gonzalez Cabrera Alberto Heras Ismael Medina Manzano Jesus Meseguer Cortés Paola Pardo-Castillo Rajvi Anandpara Juan David Barreto Ines Barros Ludovica Battista Shubhankar Bhajekar Elise Durand Drishti Gandhi Maria Karagianni Bansi Mehta Alessandro Peja Meeerati Rana Mishti Shah Saumil Shanghavi JoséHevia(摄影) 范嘉苑(编译) | 2023 | 现代装饰2023，，2： | 0 |
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