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| 1 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Involvement of the pancreas in AIDS: a prospective study of 109 post-mortems显示文摘 | Ethel Z Chehter Maria Antonieta Longo Antonio A Laudanna Maria Irma S Duarte | 2000 | AIDS2000，，13： | 1 |
| 4 | Notch signaling is required for the survival of epithelial stem cells in the continuously growing mouse incisor显示文摘 | Szabolcs F Mafika S Irma T | 2010 | Differentiation2010，80，45： | 1 |
| 5 | 2009Alzheimefs disease fact and figures显示文摘 | Mebane-Sims Irma Alzheimer's Association | | 0，，03： | 1 |
| 6 | Antibiotic ter- penoid chlorodihydroquinones from a new marine actinomycete 显示文摘 | IRMA E S M ALEJANDRA P D PAUL R J | 2005 | J Natur Prod2005，68，6： | 1 |
| 7 | Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete 显示文摘 | Irma E S M Alejandra P D Jensen P R | 2005 | J Nat Prod2005，68，6： | 1 |
| 8 | Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete显示文摘 | Irma E S Alejandra P Paul R J | 2005 | J Nat Prod2005，68，： | 1 |
| 9 | Distinctive anti-allergy properties oftwo probiotic bacterial strains in a mouse model of allergicpoly-sensitization显示文摘 | Irma S Karin H | 2011 | Vaccine2011，，29： | 1 |
| 10 | The ( G > A ) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study显示文摘 | Gilberto Vargas-Alarcón Carlos Posadas-Romero Teresa Villarreal-Molina Edith Alvarez-León Javier Angeles-Martinez María Elena Soto Irma Monroy-Mu?oz Juan Gabriel Juárez Carlos Jerges Sánchez-Ramírez Julian Ramirez-Bello Silvestre Ramírez-Fuentes José Manu | 2014 | BioMed Research International2014，，： | 1 |
| 11 | Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly显示文摘Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis.However,the role of microtubule(MT)post-translational modifications in nuclear shape regulation and cilium disassembly has not been explored.Here we identified a novel regulator of the tubulin polyglutamylase complex(TPGC),C11ORF49/CSTPP1,that regulates cytoskeletal organization,nuclear shape,and cilium disassembly.Mechanistically,loss of C11ORF49/CSTPP1 impacts the assembly and stability of the TPGC,which modulates long-chain polyglutamylation levels on microtubules(MTs)and thereby balances the binding of MT-associated proteins and actin nucleators.As a result,loss of TPGC leads to aberrant,enhanced assembly of MTs that penetrate the nucleus,which in turn leads to defects in nuclear shape,and disorganization of cytoplasmic actin that disrupts the YAP/TAZ pathway and cilium disassembly.Further,we showed that C11ORF49/CSTPP1-TPGC plays mechanistically distinct roles in the regulation of nuclear shape and cilium disassembly.Remarkably,disruption of C11ORF49/CSTPP1-TPGC also leads to developmental defects in vivo.Our findings point to an unanticipated nexus that links tubulin polyglutamylation with nuclear shape and ciliogenesis. | Lei Wang Sharad C.Paudyal Yuchen Kang Mikito Owa Feng-Xia Liang Alexander Spektor Holger Knaut Irma Sánchez Brian D.Dynlacht | 2022 | Cell Research2022，32，2： | 1 |
| 12 | The Role of Plasma High Molecular Weight Kininogen in Experimental Intestinal and Systemic Inflammation显示文摘 | Irma Isordia-Salas Robin A. Pixley Irma M. Sáinz Carlos Martínez-Murillo Robert W. Colman | 2004 | Archives of Medical Research2004，，1： | 1 |
| 13 | Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis显示文摘 | Beatriz Lozano-Ruiz Victoria Bachiller Irma García-Martínez Pedro Zapater Isabel Gómez-Hurtado Alba Moratalla Paula Giménez Pablo Bellot Rubén Francés José Such José M. González-Navajas | 2014 | Journal of Hepatology2014，，： | 1 |
| 14 | Clinical efficacy of fluconazole,tinidazole and clindamycin vs fluconazole,tinidazole and azithromycin in the treatment of mixed cervical-vaginal infections,included those caused by Mycoplasmaand Chlamydia trachomatis显示文摘 | Jesús Roberto Villagrana-Zesati Fernando M Guerra-Infante Irma Elena | 2013 | Ginecologíay obstetricia de México2013，81，5： | 1 |
| 15 | TNFα和IL-6体外对颗粒物的反应:随颗粒物大小、季节、多环芳烃和土壤含量的变化显示文摘[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs)和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(IL-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs时,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。IL-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。 | Natalia Manzano-León Jesús Serrano-Lomelin Brisa N.Sánchez Raúl Quintana-Belmares Elizabeth Vega Inés Vázquez-López Leonora Rojas-Bracho Maria Tania López-Villegas Felipe Vadillo-Ortega Andrea De Vizcaya-Ruiz Irma Rosas Perez Marie S.O’Neill Alvaro R.Osornio-Vargas 季麟(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，12： | 1 |
| 16 | Individual venom variability in the South American rattlesnake Crotalus durissus cumanensis显示文摘 | Irma Aguilar Belsy Guerrero Ana Maria Salazar Maria E. Girón John C. Pérez Elda E. Sánchez Alexis Rodríguez-Acosta | 2007 | Toxicon2007，，2： | 1 |
| 17 | Notch signaling is required for the survival of epithelial stem cells in the continuously growing mouse incisor 显示文摘 | Szabolcs F Marika S Irma T | 2010 | Differentiation2010，80，45： | 1 |
| 18 | Analysis of antioxidative phenol- ic compounds in artichoke ( Cynara scolymus L, ) 显示文摘 | WANG M JAMES E S IRMA F A | 2003 | J Agric Food Chem2003，51，： | 1 |
| 19 | The inhibitory effects on sexual behavior and ambulatory activity of the mixed GABAA/GABAB agonist progabide are differentially blocked by GABA receptor antagonists显示文摘 | A. ?gmo Raúl G. Paredes Laura Sierra Irma Garcés | 1997 | Psychopharmacology1997，，1： | 1 |
| 20 | The Global Soil Mycobiome consortium dataset for boosting fungal diversity research显示文摘Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and distribution.This data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and macroecology.The dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all continents.The plots are supplied with geographical and edaphic metadata.The OTUs are taxonomically and functionally assigned to guilds and other functional groups.The entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential contamination.The dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published data.The GSMc dataset is available over the PlutoF repository. | Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby P.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov | 2021 | Fungal Diversity2021，，6： | 0 |
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