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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | 外暴露组与呼吸道、皮肤过敏性疾病显示文摘变态反应是由多种遗传和环境因素相互作用导致的复杂疾病。然而,过去几十年间变态反应发生率的增加是由同期的环境变化所致。目前,研究者认为变态反应性疾病的发生、发展和恶化都可通过暴露组学加以解释,即从妊娠开始个体所接受的特异性和非特异性外部环境的暴露总量(外暴露组)及其对器官和细胞水平的影响(内暴露组)。在研究最深入的外暴露环境因素中,室内和室外空气变应原和空气污染物在变应原的炎性反应发病机制和变态反应性疾病的临床表现中发挥关键作用。气候变化、城市化和生物多样性的丧失会对主要的空气变应原和空气污染物的来源、排放和浓度造成影响,这将是现今和未来数十年变态反应患者的健康和生活质量所面临的最严峻的挑战之一。雷暴相关性哮喘是一个由多种环境因素作用引起的变态反应的生动例子,也可作为了解呼吸道过敏发病机制的体内模型。环境或生活方式引起的肠道和皮肤微生物组异常是变态反应性疾病的关键介质。更好地了解外暴露组对变态反应发展的影响对于敦促患者、卫生专业人员和政策制定者采取行动以减轻环境变化的影响,并适应环境变化具有重要意义。 | Lorenzo Cecchi Gennaro D Amato Isabella Annesi-Maesano 高楠楠(翻译) 王俊(翻译) 刘鹏 徐凯峰(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 3 | Effects of malachite green (MG) and its major metabolite leucomalachite green (LMG) in two human cell lines显示文摘 | Annalaura S Carlo N Isabella D A | 2005 | Toxicology in Vitro2005，19，7： | 1 |
| 4 | Aprospective,randomized study comparing percutaneous with surgical tracheostormy in critically ill patients显示文摘 | Bradley D Freeman Karen Isabella J Perren Cobb | 2001 | Crit Care Med2001，29，5： | 1 |
| 5 | A sensitive one-step re- al-time PCR for detection of avian influenza viruses using a MGB probe and an internal positive control显示文摘 | Livia D T Barbara B Isabella D | 2006 | BMC Infect Dise2006，6，1： | 1 |
| 6 | Microembolic signals with serial transcranial Doppler monitoring in acute focal ischemic deficit显示文摘 | Massimo D Silvia A Isabella S | 1997 | Stroke1997，28，7： | 1 |
| 7 | Effectsof malachite green( MG) and its major metabolite,leucomalachitegreen( LMG) , in two human cell lines 显示文摘 | ANNALAURA S B CARLO N A ISABELLA D A | 2005 | Toxicol in Vitro2005，19，： | 1 |
| 8 | A Rabl0- dependent mechanism for polarized basement membrane secre- tion during organ morphogenesis显示文摘 | LERNER DW MCCOY D ISABELLA AJ | 2013 | Dev Cell2013，24，2： | 1 |
| 9 | Efficacy of platelet gel in reconstructive bone surgery显示文摘 | Massimo F Paolo D Isabella F | 2005 | Orthopedics2005，28，2： | 1 |
| 10 | Ethanol production in immobilized-cell bioreaetors from mixed sugar syrups and enzymatic hydrolysates of steam-exploded biomass显示文摘 | Isabella D B Daniela C Francesco N | 2004 | Applied Biochemistry and Biotechnology2004，，： | 1 |
| 11 | A sensitive one- step real-time PCR for detection of avian influenza virusesusing a MGB probe and an internal positive control显示文摘 | Livia D T Barbara B Isabella D | 2006 | BMC Infectious Diseases2006，，： | 1 |
| 12 | Efficacy of platelet gel in reconstructive bone surgery显示文摘 | Massimo F Paolo D Isabella F | 2005 | Orthopedics2005，28，2： | 1 |
| 13 | Protein carbonyl groups as biomarkers of oxidative stress显示文摘 | ISABELLA D R_ANIERI R DANIELA G | 2003 | Clin Chim Acta2003，，329： | 1 |
| 14 | Critical care management of major hydrofluoric acid burns: a case report, review of the literature, and recommendations for therapy显示文摘 | Martin W Dünser Markus ?hlbauer Josef Rieder Isabella Zimmermann Helmut Ruatti Anton H Schwabegger Florian Bodrogi Georg M Huemer Barbara E Friesenecker Andreas J Mayr Philipp Lirk | 2004 | Burns2004，，4： | 1 |
| 15 | A predictive study of the mechanical behavior of coronary stents by computer modeling 显示文摘 | Francesco M Lorenza P Valeria M Isabella Q Ferdinando A Gabriele D | 2005 | Medical Engineering Physics2005，27，： | 1 |
| 16 | A meta-analysis of prospective trials comparing percutaneous and surgical tracheostomy in criti- cally ill patients显示文摘 | Freeman B D Isabella K Lin N et aI | 2000 | Chest2000，118，： | 1 |
| 17 | A meta-analysis of prospective trails comparing percutaneous and surgicall tracheostomy in critically ill patients显示文摘 | FREEMAN B D ISABELLA K LIN N | 2000 | Chest2000，118，5： | 1 |
| 18 | A metaanalysis of prospeetivetrials eomparing percutaneous and surgical trachecstomy in eriti-eally Ⅲ patienta显示文摘 | Freeman B D Isabella K Lin N | 2000 | Chest2000，118，5： | 1 |
| 19 | A single-nucleotide polymorphism in the human bone morphogenetic protein-4 (BMP 4) gene显示文摘 | Massimo M Isabella T Alessandro D L | 1999 | J Hum Genet1999，44，： | 1 |
| 20 | Effects of malachite green (MG) and its major metabolite,leucomalachite green (LMG),in two human cell lines显示文摘 | Annalaura S B Carlo N A Isabella D A | 2005 | Toxicol in Vitro2005，19，： | 1 |
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