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| 1 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Alliance management: a view from the past and a look to the future显示文摘 | Spckman R E Forbes T M Isabella L A Macavoy T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 4 | SPARC in cancer biology:its role in cancer pro- gression and potential for therapy 显示文摘 | Isabella T Michelle J | 2008 | Drug Resist Updat2008，11，6： | 1 |
| 5 | An alternative synthesis of tematloxacin, a potent antibacterial agent 显示文摘 | Daniel T W Chu Isabella M Lieo Akiyo K Claiborne | 1992 | Can J Chem1992，70，： | 1 |
| 6 | SPARC in cancer biology:Its role in cancer pro-gression and potential for therapy显示文摘 | Isabella T Michelle J | 2008 | Drug resistance Updates2008，，11： | 1 |
| 7 | A sensitive one-step re- al-time PCR for detection of avian influenza viruses using a MGB probe and an internal positive control显示文摘 | Livia D T Barbara B Isabella D | 2006 | BMC Infect Dise2006，6，1： | 1 |
| 8 | Alliances Management: a View from Past and a Look to the Future显示文摘 | Spekman R E Isabella L A Macavor T C | 1998 | Journal of Management Studies1998，，6： | 1 |
| 9 | Alliance management: A view from the past and a look to the future 显示文摘 | SPEKMAN R E FORBES T M ISABELLA L A MACAVOR T C | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 10 | Creating Strategic Alliances which Edure显示文摘 | Spekman R E Isabella L A MacAvoy T C | 1996 | Long Range Planning1996，，29： | 1 |
| 11 | A comparative study of the NH3-SCR reactions over a Cu-zeolite and a Fe-zeolite catalyst 显示文摘 | MASSIMO C ISABELLA N ENRICO T | 2010 | Catalysis Today2010，151，： | 1 |
| 12 | Alliance management: A view from the past and a look to the future 显示文摘 | Spekman R E Forbes T M Isabella L A | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 13 | An antibody-based microarray assay for the simultaneous detection of aflatox- in Bl and fumonisin B1 显示文摘 | Ilaria L Caterina T Isabella S | 2009 | Mycotoxin Research2009，25，4： | 1 |
| 14 | Optimal Design of Survivable Mesh Networks Based on Line Switched WDM Self-healing Rings显示文摘 | Andrea F Isabella C Marco T | | 0，，03： | 1 |
| 15 | Alliance Management: A View from the Past and a Look to the Future显示文摘 | Spekman R E Forbes T M Isabella L A Macavor T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 16 | Alliance management:a view from the past and a look to the future显示文摘 | SPEKMAN R E FORBES T M ISABELLA L | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 17 | Alliance management : a view from the past and a look to the future 显示文摘 | SPEKMAN R E FORBES Ⅲ T M ISABELLA L A MACAVOY T C | | Journal Of Management Studies0，35，6： | 1 |
| 18 | A sensitive one- step real-time PCR for detection of avian influenza virusesusing a MGB probe and an internal positive control显示文摘 | Livia D T Barbara B Isabella D | 2006 | BMC Infectious Diseases2006，，： | 1 |
| 19 | Associations of serologic markers of infection and inflammation with vascular disease events and mortality in American dialysis patients显示文摘 | Krista L Lentine J P Isabella T | 2006 | Clin Exp Nephrol2006，10，： | 1 |
| 20 | Adolph Paviovich Yushkevich(On the Occasion of His Seventieth Anniversary显示文摘 | BASHMAKOVA Isabella GRIGORYAN A T MARKUSHEVICH A I | 1976 | Historia Mathematica1976，3，3： | 1 |
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