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| 1 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 2 | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury显示文摘Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure,a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury.Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines,such as interleukin-1β and interleukin-18.These cytokines play a pivotal role in facilitating innate immune responses and inflammation.Among various inflammasome complexes,the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is the best characterized,a crucial role for NLRP3 has been demonstrated in various brain diseases,including traumatic brain injury.Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury.Even more important,blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury.In this review,we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome.Moreover,we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI,and current advances and challenges in potential NLRP3-targeted therapies.A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes. | Saifudeen Ismael Heba A.Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat | 2021 | Neural Regeneration Research2021，16，1： | 5 |
| 3 | Progesterone treatment nor- malizes the levels of cell proliferation and cell death in the den- tate gyms of the hippocampus after traumatic brain injury 显示文摘 | Barha CK Ishrat T Epp JR | 2011 | Exp Neurol2011，231，1： | 1 |
| 4 | Thioredoxin-inter- acting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice显示文摘 | ISHRAT T MOHAMED IN PILLAI B | 2014 | Molecular Neurobiology2014，51，2： | 1 |
| 5 | Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT) 显示文摘 | Ishrat T Hoda MN Khan MB | 2009 | Eur Neuropsychopharma- col2009，19，9： | 1 |
| 6 | Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction显示文摘 | Risheng Xu Bindu D. Paul Dani R. Smith Richa Tyagi Feng Rao A. Basit Khan Daniel J. Blech M. Scott Vandiver Maged M. Harraz Prasun Guha Ishrat Ahmed Nilkantha Sen Michela Gallagher Solomon H. Snyder | 2013 | Proceedings of the National Academy of Sciences2013，，： | 1 |
| 7 | Connective tissue growth factor expression hints at aggressive nature of colorectal cancer显示文摘BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including cancer.AIM To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological parameters.METHODS Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16.RESULTS CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens.The higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural invasion.As per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients.Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival.CONCLUSION Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients.These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC. | Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid Kulsum Akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan Mohsin Kazi Muhammad D Hussain Mudassar Syed | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 8 | Rutin protects the neural dam- age induced by transient focal ischemia in rats 显示文摘 | Khan MM Abroad A Ishrat T | 2009 | Brain Res2009，1292，： | 1 |
| 9 | Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases显示文摘 | Tauheed Ishrat Iqbal Sayeed Fahim Atif Fang Hua Donald G. Stein | 2010 | Experimental Neurology2010，，1： | 1 |
| 10 | Structural,electrical, optical and analytical applications of newly synthesized polyanilinebased nickel molybdate composite 显示文摘 | Khan MerajAlam Ishrat | 2015 | Journal of Alloys and Compounds2015，636，： | 1 |
| 11 | Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinaseB signaling pathway显示文摘 | Ishrat T Sayeed I Atif F | | 0，，： | 1 |
| 12 | Rutin protects the neural damage induced by transient focal ischemia in rats显示文摘 | Khan MM Ahmad A Ishrat T Khuwaja G Srivastawa P Khan MB Raza SS Javed H Vaibhav K Khan A Islam F | | 0，，： | 1 |
| 13 | Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia byregulating the expression of matrix metalloproteinases显示文摘 | Ishrat T Sayeed I Atif F | 2010 | Exp Neurol2010，226，1： | 1 |
| 14 | Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway显示文摘 | Ishrat T Sayeed I Atif F | | 0，，： | 1 |
| 15 | Towards Machine Learning Based Intrusion Detection in IoT Networks显示文摘The Internet of Things(IoT)integrates billions of self-organized and heterogeneous smart nodes that communicate with each other without human intervention.In recent years,IoT based systems have been used in improving the experience in many applications including healthcare,agriculture,supply chain,education,transportation and traffic monitoring,utility services etc.However,node heterogeneity raised security concern which is one of the most complicated issues on the IoT.Implementing security measures,including encryption,access control,and authentication for the IoT devices are ineffective in achieving security.In this paper,we identified various types of IoT threats and shallow(such as decision tree(DT),random forest(RF),support vector machine(SVM))as well as deep machine learning(deep neural network(DNN),deep belief network(DBN),long short-term memory(LSTM),stacked LSTM,bidirectional LSTM(Bi-LSTM))based intrusion detection systems(IDS)in the IoT environment have been discussed.The performance of these models has been evaluated using five benchmark datasets such as NSL-KDD,IoTDevNet,DS2OS,IoTID20,and IoT Botnet dataset.The various performance metrics such as Accuracy,Precision,Recall,F1-score were used to evaluate the performance of shallow/deep machine learning based IDS.It has been found that deep machine learning IDS outperforms shallow machine learning in detecting IoT attacks. | Nahida Islam Fahiba Farhin Ishrat Sultana M.Shamim Kaiser Md.Sazzadur Rahman Mufti Mahmud A.S.M.Sanwar Hosen Gi Hwan Cho | 2021 | Computers, Materials & Continua2021，，11： | 1 |
| 16 | Progesterone allopregnanoone attenu- ate blood-brain barrier dysfunction following permanent focal isch- emia by regulating the expression of matrix metalloproteinases 显示文摘 | Ishrat T Sayeed I Atif F | 2010 | Exp Neurol2010，226，1： | 1 |
| 17 | Presence of heavy metals in fruits and vegetables:Health risk implications in Bangladesh显示文摘 | Nazma S Nafis M Ishrat N K | 2016 | Chemosphere2016，152，： | 1 |
| 18 | Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuropro- teetion after oxygen and glucose deprivation:role of vascular en- dothelial growth factors A and B显示文摘 | Soliman S Ishrat T Pillai A | 2014 | The Journal bf pharmacology and experimental therapeutics2014，349，3： | 1 |
| 19 | Genital tuberculosis in the infertile women-anupdate显示文摘 | Ishrat S Fatima P | 2015 | Mymensingh Med J2015，24，1： | 1 |
| 20 | Progesterone is neuroproteetive against ischemic brain injury through its effects on the phos- phoinositide 3 - kinase/protein kinase B signaling pathway 显示文摘 | Ishrat T Sayeed I Atif F | 2012 | Neuroscience2012，110，： | 1 |
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