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| 1 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 2 | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury显示文摘Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure,a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury.Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines,such as interleukin-1β and interleukin-18.These cytokines play a pivotal role in facilitating innate immune responses and inflammation.Among various inflammasome complexes,the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is the best characterized,a crucial role for NLRP3 has been demonstrated in various brain diseases,including traumatic brain injury.Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury.Even more important,blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury.In this review,we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome.Moreover,we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI,and current advances and challenges in potential NLRP3-targeted therapies.A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes. | Saifudeen Ismael Heba A.Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat | 2021 | Neural Regeneration Research2021，16，1： | 5 |
| 3 | Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats显示文摘 | Tauheed I Iqbal S Fahim A | 2009 | Brain Res2009，1257，： | 1 |
| 4 | Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases显示文摘 | Tauheed Ishrat Iqbal Sayeed Fahim Atif Fang Hua Donald G. Stein | 2010 | Experimental Neurology2010，，1： | 1 |
| 5 | Correlation of Waistto-hip Ratio(WHR)and Oxidative Stress in Patients of Acute Myocardial Infarction(AMI)显示文摘 | Siddiqui AH Gulati R Tauheed N | 2014 | Clin Diagn Res2014，8，1： | 1 |
| 6 | Selenium prevents cog-nitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type显示文摘 | Tauheed I Kehkashan P Mohd MK | 2009 | Brain Research2009，，1281： | 1 |
| 7 | Frequency of autoim- mune thyroid disease in chronic urticaria 显示文摘 | Aamir IS Tauheed S Majid F | 2010 | J Coll Physi- cians Surg Pak2010，20，3： | 1 |
| 8 | Progesterone and llo- pregnanolone attenuate blood - brain barrier dysfunction following per- manent focal ischemia by regulating the expression of matrix metallo- proteinases显示文摘 | Tauheed lshrat Iqbal Sayeed Fahim Atif | 2010 | Exp Neurol2010，226，1： | 1 |
| 9 | Levels of non-high density lipoprotein cholesterol(non-HDL)in patients with ischaemic heart disease显示文摘 | Tauheed S Shomb S ul Haque MN | 2003 | J Ayub Med Coll Abbottabad2003，15，1： | 1 |
| 10 | Multiple giant cell tumor of the tendon sheath: a rare occurrence显示文摘 | Pathade S C Kurpad R Tauheed M | 2014 | J Clin I)iagn Res2014，8，1： | 1 |
| 11 | Serum antithyroid antibodies in fe-male patients with chronic urticarial 显示文摘 | Aamir IS Tauheed S Majeed F | 2008 | J Coll Physicians Surg Pak2008，18，8： | 1 |
| 12 | Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats:behavioral,neurochemical and immunohistochemical studies显示文摘 | Gulrana Khuwaja Mohd Moshahid Khan Tauheed Ishrat | | 0，，12： | 1 |
| 13 | Serum homocysteine concentrations in patients with hypertension显示文摘 | Atif A Rizvi MA Tauheed S | 2008 | Pak J Phys- iol2008，4，1： | 1 |
| 14 | Multiple giant cell tumours of tendon sheath:a rare occurrence显示文摘 | Pathade SC Kurpad R Tauheed M | 2014 | J Clin Diagn Res2014，8，1： | 1 |
| 15 | Frequency of autoim- mune thyroid disease in chronic urticaria显示文摘 | Aamir IS Tauheed S Majid F | 2010 | Coll Physi- cians Surg Pak2010，20，3： | 1 |
| 16 | Frequency of autoimmune thyroid disease in chronic urticaria显示文摘 | Aamir IS Tauheed S Majid F | 2010 | J Coll Physicians Surg Pak2010，20，3： | 1 |
| 17 | Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat显示文摘 | Ajmal Ahmad Mohd. Moshahid Khan Hayate Javed Syed Raza Tauheed Ishrat M. Badruzzaman Khan Mohammed Safhi Fakhrul Islam | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 18 | Frequency of autoimmune thy-roid disease in chronic urticaria显示文摘 | Aamir IS Tauheed S Majid F | 2010 | J Coll Physicians Surg Pak2010，20，3： | 1 |
| 19 | Repurposing verapamil for prevention of cognitive decline in sporadic Alzheimer's disease显示文摘Dementia is currently the only leading cause of death that is still on the rise,with its overall costs already surpassing those of cancer and heart disease combined,it has developed into a worldwide crisis.In response to its serious and far-reaching effects,the US government has established the'National Alzheimer's Project Act'(Public Law 111-375). | Heba A.Ahmed Tauheed Ishrat | 2022 | Neural Regeneration Research2022，17，5： | 0 |
| 20 | Verapamil,a possible repurposed therapeutic candidate for stroke under hyperglycemia显示文摘Admission hyperglycemia is an independent predictor,that contributes to hemorrhagic transformation (HT),and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic stroke.Clinical studies have revealed a strong association between hyperglycemia and incidence of HT independent of prior diabetes diagnosis (Alvarez-Sabin et al. | Saifudeen Ismael Tauheed Ishrat | 2022 | Neural Regeneration Research2022，17，11： | 0 |
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