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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | 谈教育考试国家题库建设现状及展望显示文摘教育考试国家题库建设是我国教育考试“十一五”期间的一项重要工作任务。本文主要从国家教育考试题库建设的思想建设、制度建设、工作转轨、软硬件设备等几个方面对题库建设一期工作的开展情况进行了介绍,并对今后的题库建设工作进行了展望。 | Task Group of Item Banking for National Education Examinations | 2008 | 中国考试2008，，6： | 3 |
| 3 | Bioaugmentation: a new strategy for removal of recalcitrant compounds in wastewater—a case study of quinoline显示文摘IntroductionInrecentyearsxenobioticshavecaughtworldsattentionbecausetheyarepoorlybiodegradableandthreatenpublichealthifhandle... | HAN Li\|ping\+*, WANG Jian\|long, SHI Han\|chang, QIAN Yi (State Key Joint Laboratory of Environmental Simulation and Pollution Control, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China) Foundation item | 2000 | Journal of Environmental Sciences2000，12，1： | 2 |
| 4 | Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells显示文摘 | Niessen M Jaschinski F Item F | 2007 | Exp Cell Res2007，313，4： | 1 |
| 5 | GEF2020: Strategy for the GEF 显示文摘 | Assembly F GEF Item A | 2014 | 2014，，： | 1 |
| 6 | Visceral fat and metabolic inflammation:the portal theory revisited显示文摘 | Item F Konrad D | 2012 | Obes Rev2012，132，： | 1 |
| 7 | Molecular characterisation of 34 patients with biotinidase deficiency ascertained by newborn screening and family investigation 显示文摘 | Muhl A Moslinger D Item CB | 2001 | Eur J Hum Genet2001，9，4： | 1 |
| 8 | Stem radius changes and their relation to stored water in stems of young Norway spruce trees 显示文摘 | ZWEIFEL R ITEM H HASLER R | 2000 | Treesy2000，15，1： | 1 |
| 9 | Mutations at the galactose-1-p-uridyltansferase gene in infants with a positive galactosemia newborn screening test 显示文摘 | Item C Hagerty EP Muhl A | 2002 | Pediatr Res2002，51，4： | 1 |
| 10 | Transformation of pleo- morphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of 1353 mutations显示文摘 | Gedlicka C Item CB Wgerbaner M | 2010 | J Surg Oneol2010，101，2： | 1 |
| 11 | Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice显示文摘 | Wueest S Item F Boyle CN | 2014 | Am J Physi- ol Regul Integr Comp Physiol2014，306，11： | 1 |
| 12 | Link between diurnal stem radius changes and tree water relations 显示文摘 | Zweifel R Item H Hasler R | 2001 | Tree Physiology2001，21，： | 1 |
| 13 | Effects of wtha- nol extract of azadirachta indica leaves on some immunologi- cal and haematological parameters of diabetic wistar rats 显示文摘 | Itemobong S E Item J A Henry D A | 2010 | African Journal of Pharmacy and Pharmacology2010，4，3： | 1 |
| 14 | Vitamin B12 deficiencyza challenging diagnosis and treatment 显示文摘 | Rufenaeht P Maeh-Paseual S Item A | 2008 | Rev Med Suisse2008，4，175： | 1 |
| 15 | Evidence of osteocalein expression in osteoblast cells of mandibular origin growing on biomaterials with RT-PCR and SDSPAGE/Western blotting显示文摘 | Turhani D Item C Thurnher D | 2003 | Mund Kiefer Gesichtschir2003，7，5： | 1 |
| 16 | Molecular analysis of guanidinoacetate-n-methyltransferase(GAMT)and creatine transporter(SLC6A8)gene by using denaturing high pressure liquid chromatography(DHPLC)as a possible source of human male infertility显示文摘 | Iqbal F Item CB Ratschmann R | 2011 | Pak J Pharm Sci2011，24，1： | 1 |
| 17 | Visceral fat and metabolic inflammation: the portal theory revisited 显示文摘 | Item F Konrad D | 2012 | Obes Rev2012，13，12： | 1 |
| 18 | Antioxidant versus anti-diabetic properties of leaves from Vernonia amygdalina Del. growing in Malaysia显示文摘 | Item J. Atangwho Godwin E. Egbung Mariam Ahmad Mun F. Yam Mohd Z. Asmawi | 2013 | Food Chemistry2013，，4： | 1 |
| 19 | Conceptional Analysis and Comparative Studies for Optional Solution 显示文摘 | Theodor Itemize Prefabricated lining | 1994 | Tunneling and Ground Conditions1994，，： | 1 |
| 20 | Mutation analysis of CLPTM1 and PYRL1 genes in patients with non - syndromic clefts of lip, alveolus and palate 显示文摘 | D Turhani C B Item E Watzinger | 2005 | Journal of Cranio - Maxillofacial Surgery2005，33，5： | 1 |
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