|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma显示文摘AIM: To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients. METHODS: A prospective cohort study, from 2001 to 2010, compared clinical outcomes following TACE between patients ≥ 75 years old and younger patients (aged between 65 and 75 years and younger than 65 years) with hepatocellular carcinoma (HCC), diagnosed according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases criteria. The decision that patients were not candidates for curative therapy was made by a multidisciplinary HCC team. Data collected included demographics, co-morbidities, liver disease etiology, liver disease severity and the number of procedures. The primary outcome was mortality; secondary outcomes included post-embolization syndrome (nausea, fever, abdominal right upper quadrant pain, increase in liver enzymes with no evidence of sepsis and with a clinical course limited to 3-4 d post procedure) and 30-d complications. Additionally, changes in liver enzyme measurements were assessed [alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transpeptidase and alkaline phosphatase] in the week following TACE. Analysis employed both univariate and multivariate methods (Cox regression models). RESULTS: Of 102 patients who underwent TACE as sole treatment, 10 patients (9.8%) were > 80 years old at diagnosis; 13 (12.7%) were between 75 and 80 years, 45 (44.1%) were between 65 and 75 years and 34 (33.3%) were younger than 65 years. Survival analysis demonstrated similar survival patterns between the elderly patients and younger patients. Age was also not associated with the adverse event rate. Survival rates at 1, 2 and 3 years from diagnosis were 74%, 37% and 31% among patients < 65 years; 83%, 66% and 48% among patients aged 65 to 75 years; and 86%, 41% and 23% among patients ≥ 75 years. There were no differences between the age groups in the pre-procedural care, including preventive treatment for contrast nephropathy and prophylactic antibiotics. Multivariate survival analysis, controlling for disease stage at diagnosis with the Barcelona Clinic Liver Cancer score, number of TACE procedures, sex and alphafetoprotein level at the time of diagnosis, found no significant difference in the mortality hazard for elderly vs younger patients, and there were no differences in post-procedural complications. Serum creatinine levels did not change after 55% of the procedures, in all age groups. In 42% of all procedures, serum creatinine levels increased by no more than 25% above the baseline levels prior to TACE. Overall, there were 69 post-embolization events (23%). Hepatocellular enzymes often increased following TACE, with no association with prognosis. In 40% of the procedures, ALT and AST levels rose by at least 100%. The increases in hepatocellular enzymes occurred similarly in all age groups. CONCLUSION: TACE is safe and effective in very elderly patients with HCC, and is not associated with decreased survival or increased complication rates. | Matan J Cohen Allan I Bloom Orly Barak Alexander Klimov Tova Nesher Daniel Shouval Izhar Levi Oren Shibolet | 2013 | World Journal of Gastroenterology2013，19，16： | 13 |
| 2 | Primary hepatic solitary fibrous tumor with histologically benign and malignant areas显示文摘Extrapleural solitary fibrous tumor(SFT) is an uncommon mesenchymal neoplasm,presenting most commonly in the intrathoracic sites but which has been reported at numerous extrathoracic locations. The majority of intra-thoracic SFTs are benign,but 10%-15% behave aggressively. We report a case of primary hepatic SFT with histologically benign and malignant areas. A 65-year-old man underwent an abdominal CT scan following a cerebrovascular accident,which demonstrated a sharply demarcated large liver mass with a heterogenous enhancing area and occupying most of the left lobe of the liver. Histological examination following a hemihepatectomy showed an SFT with morphological patterns ranging from benign to malignant areas,including pleomorphism,increased cellularity,herringbone pattern,necrosis and a raised mitotic count. On review of the literature,only an occasional case report with malignant areas in a hepatic SFT was identified. This case highlights that SFT should be included in the differential diagnosis of a hepatic spindle cell lesion,and that on rare occasions,malignant areas can occur in this already uncommon neoplasm. | Anna Silvanto Nariman D Karanjia Izhar N Bagwan | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 10 |
| 3 | Simulation of Vortex-Induced Vibrations of A Cylinder Using ANSYS CFX显示文摘In this paper, vortex-induced vibrations of a cylinder are simulated by use of ANSYS CFX simulation code. The cylinder is treated as a rigid body and transverse displacements are obtained by use of a one degree of freedom spring damper system. 2-D as well as 3-D analysis is performed using air as the fluid. Reynolds number is varied from 40 to 16000 approx., covering the laminar and turbulent regimes of flow. The experimental results of(Khalak and Williamson, 1997) and other researchers are used for validation purposes. The results obtained are comparable. | Abu Bakar IZHAR Arshad Hussain QURESHI Shahab KHUSHNOOD | 2014 | China Ocean Engineering2014，28，4： | 5 |
| 4 | 电站低温给水系统腐蚀产物生成过程研究显示文摘燃煤电站汽水系统中低温给水部件由于流动加速腐蚀产生大量腐蚀产物,这些腐蚀产物随工质在整个汽水系统中迁徙,严重影响了机组的运行安全及寿命。基于质量平衡方程,建立了腐蚀产物的生成模型,从3种不同角度分析了金属氧化层孔隙率、铁在工质中的扩散系数和工质p H值等对腐蚀速率的影响。结果显示:腐蚀速率分别与前两者成正比关系,而与工质的p H值成反比关系。给水加氧处理可使金属氧化膜的孔隙率明显降低,而管道布置越复杂、管道表面越粗糙,铁在工质中的扩散系数越大。因此,燃煤电站在实际运行中,可通过管道结构优化,选择最佳给水处理方式,在最佳p H值和溶氧量条件下抑制流动加速腐蚀,减少腐蚀产物的产生。 | 蒋东方 张冕 KHAN Izhar Hasan 王超 朱忠亮 张乃强 徐鸿 | 2018 | 中国电力2018，51，5： | 2 |
| 5 | S100B interaction with the receptor for advanced glycation end products(RAGE):a novel receptor-mediated mechanism for myocyte apoptosis postinfarction显示文摘 | Tsoporis JN Izhar S Leong-Poi H | 2010 | Circ Res2010，106，1： | 1 |
| 6 | Transition metal phosphide catalysts for hydrogen oxidation reaction显示文摘 | Izhar S Nagai M | 2009 | Catalysis Today2009，146，12： | 1 |
| 7 | S100B interaction with the receptor for advanced glycation end products (RAGE):a novel receptor-mediated mechanism for myocyte apoptosis postinfarction显示文摘 | Tsoporis JN Izhar S Leong-Poi H | | 0，，01： | 1 |
| 8 | CXCR4/CXCL12 axis in non small cell lung cancer(NSCLC) pathologic roles and therapeutic potential显示文摘 | Wald O Shapira OM Izhar U | 2013 | Theranostics2013，3，1： | 1 |
| 9 | Yttrium-90–ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin’s lymphoma显示文摘 | Avichai Shimoni S. Tzila Zwas Yakov Oksman Izhar Hardan Noga Shem-Tov Ronit Yerushalmi Abraham Avigdor Isaac Ben-Bassat Arnon Nagler | 2007 | Experimental Hematology2007，，4： | 1 |
| 10 | CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth显示文摘 | Katia Beider Michal Begin Michal Abraham Hanna Wald Ido D. Weiss Ori Wald Eli Pikarsky Evelyne Zeira Orly Eizenberg Eithan Galun Izhar Hardan Dan Engelhard Arnon Nagler Amnon Peled | 2011 | Experimental Hematology2011，，3： | 1 |
| 11 | Non‐surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial显示文摘 | Syed A. H. Bokhari Ayyaz A. Khan Arshad K. Butt Mohammad Azhar Mohammad Hanif Mateen Izhar Dimitris N. Tatakis | 2012 | J Clin Periodontol2012，，11： | 1 |
| 12 | S1 00B interaction with the receptor for advanced glycation end products (RAGE):a novel receptor-mediated mechanism for myocyte apoptosis postinfarction显示文摘 | Tsoporis J N Izhar S Leong-Poi H | 2010 | Circ Res2010，106，1： | 1 |
| 13 | Higher order symmetric duality in nondifferentiable multi- objective programming problems involving generalized cone convex functions显示文摘 | Ravi P Agarwal Izhar Ahmad Anurag Jayswal | 2010 | Mathematical and Computer Modelling2010，52，910： | 1 |
| 14 | The effect of cytokininson vitrification in melon and carnation 显示文摘 | Leshem B Shaley D P Izhar S | 1988 | Annalsof Botany1988，62，2： | 1 |
| 15 | Minimally invasive procedures for diagnosis of traumatic right diaphragmatic tears: a method for correct diagnosis in selected patients 显示文摘 | Mintz Y Easter DW Izhar U | 2007 | Am Surg2007，73，4： | 1 |
| 16 | Massive empyema caused by Mycoplasma pneumoniae in an adult:a case report显示文摘 | Shuvy M Rav Acha M Izhar U | | 0，，： | 1 |
| 17 | Goal-oriented hypertension management: translating clinical trials to practice显示文摘 | Singer GM Izhar M Black HR | 2002 | Hypertension2002，40，4： | 1 |
| 18 | Thermal imaging in medicine显示文摘 | IZHAR L I PETROU M | 2012 | Advances In Imaging and Electron Physics2012，171，： | 1 |
| 19 | Development of a Rapid Quantitative PCR Assay for Direct Detection and Quantification of Culmrable and Non-culmrable Escherichia coil from Agriculture watersheds显示文摘 | IZHAR U H VIC G ROB K | 2007 | Journal of Microbiological Methods2007，69，： | 1 |
| 20 | Goal-oriented hypertension management:translating clinical trials to practice显示文摘 | Singer GM Izhar M Black HR | 2002 | Hypertension2002，40，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员