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| 1 | Murine model of acute myocarditis and cerebral cortical neuron edema induced by coxsackievirus B4显示文摘Globally, coxsackievirus B4(CV-B4) has been continuously isolated and evidence suggests an association with the development of pancreatitis and type I diabetes. In addition, CV-B4 is also associated with myocarditis and severe central nervous system(CNS) complications, which remain poorly studied and understood. In the present study, we established an Institute for Cancer Research(ICR) mouse model of CV-B4 infection and examined whether CV-B4 infection resulted in a predisposition to myocarditis and CNS infection. We found high survival in both the treatment and control group, with no significant differences in clinical outcomes observed. However, pathological lesions were evident in both brain and heart tissue of the CV-B4-infected mice. In addition, high viral loads were found in the neural and cardiac tissues as early as 2 days post infection. Expressions of IFN-γ and IL-6 in sera were significantly higher in CV-B4-infected mice compared to uninfected negative controls, suggesting the involvement of these cytokines in the development of histopathological lesions. Our murine model successfully reproduced the acute myocarditis and cerebral cortical neuron edema induced by CV-B4, and may be useful for the evaluation of vaccine candidates and potential antivirals against CV-B4 infection. | zhao-peng dong qian wang zhen-jie zhang michael j.carr dong li wei-feng shi | 2018 | Zoological Research2018，39，1： | 3 |
| 2 | The Asian Lineage of Zika Virus: Transmission and Evolution in Asia and the Americas显示文摘Since first isolation in 1947 from the Zika forest in Uganda, Zika virus(ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015–2016,an Asian lineage of ZIKV caused an unprecedentedly large outbreak in the Americas and sizeable numbers of exported cases across the globe. In this review, we critically appraise the recent advances in molecular epidemiological studies of ZIKV performed to date, and we highlight the pivotal role played by genomic surveillance in elucidating the origins,dissemination and evolution of the Asian lineage of ZIKV in Asia and in the Americas. | Tao Hu Juan Li Michael J.Carr Sebastián Duchêne Weifeng Shi | 2019 | Virologica Sinica2019，34，1： | 3 |
| 3 | Standards for ecologically successful river restoration显示文摘 | M.A.PALMER E.S.BERNHARDT J. D.ALLAN P.S.LAKE G.ALEXANDER S.BROOKS J.CARR S.CLAYTON C. N.DAHM J.FOLLSTAD SHAH D. L.GALAT S. G.LOSS P.GOODWIN D.D.HART B.HASSETT R.JENKINSON G.M.KONDOLF R.LAVE J.L.MEYER T.K.O’DONNELL L.PAGANO E.SUDDUTH | 2005 | Journal of Applied Ecology2005，，2： | 2 |
| 4 | 制造量子黑洞显示文摘从发明粒子加速器起近80年时间里,物理学家们已经用它们做了些很奇妙的工作,如分裂原子、改变元素、制造反物质以及制造以前从未在自然界中观测到的粒子.不过,幸运的话不久他们就可以迎接一项新的挑战,这将使以前的成果黯然失色.这些加速器也许会制造出宇宙中最为神秘的物体:黑洞. | Bernard J.Carr Steven B.Giddings 王超 武星 | 2005 | 科学(中文版)2005，，7： | 1 |
| 5 | Innovative seismic retrofitting strategy of added stories isolation system显示文摘The seismic performance of“added stories isolation”(ASI)systems are investigated for 12-story moment resisting frames.The newly added and isolated upper stories on the top of the existing structure are rolled to act as a large tuned mass damper(TMD)to overcome the limitation of the size of tuned mass,resulting to“12+2”and“12+4”stories building configurations.The isolation layer,as a core design strategy,is optimally designed based on optimal TMD design principle,entailing the insertion of passive flexible laminated rubber bearings to segregate two or four upper stories from a conventionally constructed lower superstructure system.Statistical performance metrics are presented for 30 earthquake records from the 3 suites of the SAC project.Time history analyses are used to compute various response performances and reduction factors across a wide range of seismic hazard intensities.Results show that ASI systems can effectively manage seismic response for multi-degree-of freedom(MDOF)systems across a broader range of ground motions without requiring burdensome extra mass.Specific results include the identification of differences in the number of added story by which the suggested isolation systems remove energy. | Min-Ho CHEY J.Geoffrey CHASE John B.MANDER Athol J.CARR | 2013 | Frontiers of Structural and Civil Engineering2013，7，1： | 1 |
| 6 | Standards for ecologically successful river restoration显示文摘 | M.A.PALMER E.S.BERNHARDT J. D.ALLAN P.S.LAKE G.ALEXANDER S.BROOKS J.CARR S.CLAYTON C. N.DAHM J.FOLLSTAD SHAH D. L.GALAT S. G.LOSS P.GOODWIN D.D.HART B.HASSETT R.JENKINSON G.M.KONDOLF R.LAVE J.L.MEYER T.K.O’DONNELL L.PAGANO E.SUDDUTH | 2005 | Journal of Applied Ecology2005，，2： | 1 |
| 7 | Seroprevalence of influenza viruses in Shandong,Northern China during the COVID-19 pandemic显示文摘Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China. | Chuansong Quan Zhenjie Zhang Guoyong Ding Fengwei Sun Hengxia Zhao Qinghua Liu Chuanmin Ma Jing Wang Liang Wang Wenbo Zhao Jinjie He Yu Wang Qian He Michael J.Carr Dayan Wang Qiang Xiao Weifeng Shi | 2022 | Frontiers of Medicine2022，16，6： | 1 |
| 8 | Advanced Robotics to Address the Translational Gap in Tendon Engineering显示文摘Tendon disease is a significant and growing burden to healthcare systems.One strategy to address this challenge is tssueengineering.A widely held view in this feld is that mechanical stimulation provided to constructs should replicate themechanicaienvironment of native tissue as closely as possible.We review recent tendon tissue engineering studies inthisarticle and highlight limitations of conventional uniaxial tensile bioreactors used in current literature.Advanced roboticplatforms such as musculoskeletal humanoid robots and soft robotic actuators are promising technologies which may helpaddress translational gaps in tendon tissue engineering We suggest the proposed benets of these technologies and identifyrecent studies which have worked to implement these technologies in tssue engineering.Lastly,key chalenges to addressinadapting these robotic technologies and proposed future research directions for tendon tssue engineering are discussed. | Iain L.Sander Nicole Dvorak Julie A.Stebbins Andrew J.Carr Pierre-Alexis Mouthuy | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 9 | Genitourinary melanoma:An overview for the clinician显示文摘Genitourinary (GU) melanoma is a rare presentation of melanoma accounting for approximately 0.5% of all melanomas.GU melanomas include primary melanomas of the vulva,vagina,uterine cervix,ovary,penis,scrotum,urethra,bladder,ureter,and kidney.These melanomas are often diagnosed in advanced stages and stigma is thought to contribute to delays in presentation.As the likely diagnosing provider,it is imperative that dermatologists,urologists,and gynecologists are aware of these uncommon sites of presentation.While there have been major advances in the treatment of melanomas as a whole in the last 10 years,their applications to GU melanomas have often been overlooked.GU melanomas have not been included in many of the major phase II clinical trials which brought contemporary advanced treatments to market and the prognoses for GU melanomas remain poor.Due to the rarity of GU melanomas,much of the literature provides gener alized recommendations across multiple different organs affected by GU melanomas or omits certain topics,making it difficult to appreciate the funda-mentals of the individual presentations.This review aimed to provide background information on the pathogenesis and epidemiology of the different sites of GU melanomas and categorize data specific to the presentation,staging,treatment,and prognosis of each type of GU melanoma to guide the clinician.It was also meant to encourage a multidisciplinary approach to the management of these patients as it spans the expertise of surgical oncologists,medical oncologists,radiation oncologist,dermatologists,urologists,and gynecologists. | Danielle K.DePalo Kelly M.Elleson Michael J.Carr Philippe E.Spiess Jonathan S.Zager | 2022 | Asian Journal of Urology2022，9，4： | 0 |
| 10 | 由O’Hagan案确立的成立内幕交易罪所必备之犯罪主观意图显示文摘联邦最高法院关于United States v.O’Hagan一案所作判决已经被广泛认为是对关于内幕交易传统理论的背离,在此判决中一种新的责任理论作为传统理论的替代,也颇受质疑。这种新出现的理论被称为内幕交易的'盗用'理论,该理论认为,被禁止的是——从事证券交易的行为人由于对未公开的信息负有某种诚信义务,而却违背这种诚信义务,运用该信息进行交易。在O’Hagan一案中,一位律师知道Pillsbury即将被要约收购,于是利用他所知道的,涉及Pillsbury的相关兼并'内幕'消息进行Pillsbury股票交易,其消息来源于该律师所在事务所,发出收购要约的公司是该所客户,法庭认为该律师应获有罪判决。采纳盗用理论的情况下。 | Brian J.Carr 林岚 | 2013 | 刑事法评论2013，，1： | 0 |
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