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| 1 | 氮沉降的全球化:对于陆地生态系统的意义显示文摘人类活动产生的氮(N),包括农田氮肥施肥和矿物燃料燃烧过程中所固定的氮,其来源和分布正在迅速地扩展到全球范围。这部分氮进入到陆地生态系统中,将会促进植物的生长,并产生过量的氮,最终通过淋溶和痕量气体排放的形式,增加了氮的损失。在某种情况下,还会导致物种组成的变化和生态系统功能的衰减。但并非所有的生态系统都对氮沉降具有类似的响应。它们的响应情况,取决于氮沉降的连续性、生态系统的类型、生态系统对氮的需求或保持能力、土地利用的历史、土壤状况、地形条件、气候背景以及氮沉降的速度、时间和类型等因素。我们认为,起重要作用的是:一些对人类影响具有显著意义的条件、一些控制生态系统响应变化的因素以及一些由于资料缺乏而使不确定性增大的地方。 | Pamela Matson Kathleen A.Lohse Sharon J.Hall 闵庆文 | 2002 | AMBIO-人类环境杂志2002，31，2： | 71 |
| 2 | Cost-effectiveness analysis of treatments for metastatic castration resistant prostate cancer显示文摘Objective:Treatment options for metastatic castration resistant prostate cancer(mCRPC)have expanded rapidly in recent years.Given the significant economic burden,we sought perform a cost-effectiveness analysis(CEA)of the contemporary treatment paradigm for mCRPC.Methods:We devised a treatment protocol consisting of sipuleucel-T,enzalutamide,abiraterone,docetaxel,radium-223,and cabazitaxel.We estimated number and length of treatments for each therapy using dosing schedules or progression free survival data from published clinical trials.We estimated treatment cost using billing data and Medicare reimbursement values and performed a CEA.Our analysis assumed US$100,000 per life year saved(LYS)as the threshold societal willingness to pay.Results:Incremental cost-effectiveness ratios(ICER)for strategies incorporating sipuleucel-T that were not eliminated by extended dominance exceeded the societal threshold willingnessto-pay of US$100,000 per LYS,the lowest of which was sipuleucel-T+enzalutamide+abiraterone+docetaxel at US$207,714 per LYS.Enzalutamide+abiraterone+docetaxel exhibited the most favorable ICER among strategies without sipuleucel-T at US$165,460 per LYS.Conclusion:Based on the available survival data and current costs of treatment,all treatment strategies greatly exceed a commonly assumed societal willingness-to-pay threshold of US$100,000 per LYS.Improvements in this regard can only comewith a reduction in pricing,better tailoring of treatment or significant enhancements in survival with clinical use of treatment combinations or sequences. | Matthew E.Pollard Alan J.Moskowitz Michael A.Diefenbach Simon J.Hall | 2017 | Asian Journal of Urology2017，4，1： | 6 |
| 3 | 广州市某两区居民社会支持状况对高危性行为影响分析显示文摘目的了解广州市某两区居民高危性行为的现状,并探讨社会支持对该人群高危性行为的影响。方法采用横断面调查的方法,在广州市越秀区和天河区采用基于人群概率的空间抽样方法随机抽取调查地点,每个调查地点在居民楼内随机选取1名18~59岁的居民进行问卷调查。调查内容包括社会人口学特征、生理和心理健康状况、健康行为及高危性行为,并采用《社会支持评定量表》评估其社会支持状况。结果采用空间随机抽样抽取调查地点1 215个,实际参与调查调查765人,应答率为62.96%。调查人群自报的多性伴和非保护性行为发生率为18.25%和52.51%。多因素Logistic回归分析显示,社会支持中的主观支持(OR=0.901,95%CI:0.847~0.958)是降低多性伴行为发生的保护因素,而对支持利用度(OR=0.844,95%CI:0.740~0.962)是减少非保护性行为的保护因素。研究结果显示年龄、性别、婚姻状况及酒精滥用情况同样影响该人群高危性行为的发生。结论在高危人群比例较高的地区,应重视高危性行为等健康行为方面的教育和指导,尤其年龄较大、女性及酒精滥用人群,改善其社会支持状况,以降低高危性行为的发生,进而有利于性传播疾病的预防控制。 | 周芳静 | 2015 | 现代预防医学2015，42，22： | 3 |
| 4 | Identification of novel molecular markers of mastitis caused by Staphylococcus aureus using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle显示文摘Background: Mastitis in dairy cows caused by Staphylococcus aureus is a major problem hindering economic growth in dairy farms worldwide. It is difficult to prevent or eliminate due to its asymptomatic nature and long persistence of infection. Although transcriptomic responses of bovine mammary gland cells to pathogens that cause mastitis have been studied, the common responses of peripheral blood leukocytes to S. aureus infection across two consecutive generations of dairy cattle have not been investigated.Methods: In the current study, RNA-Seq was used to profile the transcriptomes of peripheral blood leukocytes sampled from S. aureus-infected mothers and their S. aureus-infected daughters, and also healthy non-infected mothers and their healthy daughters. Differential gene expression was evaluated as follows: 1) S. aureus-infected cows versus healthy non-infected cows(S vs. H, which include all the mothers and daughters), 2) S. aureus-infected mothers versus healthy non-infected mothers(SM vs. HM), and 3) S. aureus-infected daughters versus healthy noninfected daughters(SMD vs. HMD).Results: Analysis of all identified expressed genes in the four groups(SM, SMD, HM, and HMD) showed that EPOR,IL9, IFNL3, CCL26, IL26 were exclusively expressed in both the HM and HMD groups, and that they were significantly(P < 0.05) enriched for the cytokine-cytokine receptor interaction pathway. A total of 17, 13 and 10 differentially expressed genes(DEGs)(FDR Padj. < 0.1 and |FC| > 1.2) were detected in the three comparisons, respectively. DEGs with P < 0.05 and |FC| > 2 were used for functional enrichment analyses. For the S vs. H comparison, DEGs detected included CCL20, IL13 and MMP3, which are associated with the IL-17 signaling pathway. In the SM vs. HM and SMD vs. HMD comparisons, five(BLA-DQB, C1 R, C2, FCGR1 A, and KRT10) and six(BLA-DQB, C3 AR1, CFI, FCAR, FCGR3 A, and LOC10498484) genes, respectively, were involved in the S. aureus infection pathway.Conclusions: Our study provides insights into the transcriptomic responses of bovine peripheral blood leukocytes across two generations of cattle naturally infected with S. aureus. The genes highlighted in this study could serve as expression biomarkers for mastitis and may also contain sequence variation that can be used for genetic improvement of dairy cattle for resilience to mastitis. | Di Wang Lei Liu Serafino M.A.Augustino Tao Duan Thomas J.Hall David E.MacHugh Jinhuan Dou Yi Zhang Yachun Wang Ying Yu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 2 |
| 5 | Are CEOS Really Paid Like Bureaucrats显示文摘 | Brian J.Hall Jeffrey B.Liebman | | 0，，： | 1 |
| 6 | 中国的数字化心理健康服务:促进健康公平的机遇与挑战显示文摘数字化心理健康服务因其可拓展性在中国具有广阔的应用前景,机遇与挑战并存。文章讨论了数字化心理健康服务在当前的实践过程中所出现的文化适应性、效果评估、用户脱落、数据互通性、用户隐私保护和科技创新问题。希望通过解决这些问题,数字化心理健康服务能够在中国迈入新的发展阶段,助力健康公平。 | Brian J.Hall 李根 | 2022 | 心理学通讯2022，5，1： | 1 |
| 7 | Role of multi-parametric MRI of the prostate for screening and staging:Experience with over 1500 cases显示文摘Objective:Contemporary prostate cancer(PCa)screening modalities such as prostate specific antigen(PSA)and digital rectal examination(DRE)are limited in their ability to predict the detection of clinically significant disease.Multi-parametric magnetic resonance imaging(mpMRI)of the prostate has been explored as a staging modality for PCa.Less is known regarding its utility as a primary screening modality.We examined our experience with mpMRI as both a screening and staging instrument.Methods:mpMRI studies performed between 2012 and 2014 in patients without PCa were cross-referenced with transrectal ultrasonography(TRUS)biopsy findings.Statistical analyses were performed to determine association of mpMRI findings with overall cancer diagnoses and clinically significant(Gleason score≥7)disease.Subgroup analyses were then performed on patients with a history of prior negative biopsy and those without a history of TRUS biopsy.mpMRI studies were also cross-referenced with RP specimens.Statistical analyses determined predictive ability of extracapsular extension(ECE),seminal vesicle involvement(SVI),and pathologic evidence of clinically significant disease(Gleason score7).Results:Four hundred biopsy naive or prior negative biopsy patients had positive mpMRI studies.Overall sensitivity,specificity,positive and negative predictive values were 94%,37%,58%,and 87%,respectively and 95%,31%,42%,and 93%,respectively for overall cancer detection and Gleason score≥7 disease.In patients with no prior biopsy history,mpMRI sensitivity,specificity,positive and negative predictive values were 94%,36%,65%,and 82%,for all cancers,and 95%,30%,50%,and 89%for Gleason score7 lesions,respectively.In those with prior negative biopsy sensitivity,specificity,positive and negative predictive values were 94%,37%,52%,and 90% for all cancers,and 96%,32%,36%,and 96% for Gleason score7 lesions,respectively.Seventy-four patients underwent radical prostatectomy(RP)after mpMRI.Lesion size on mpMRI correlated with the presence of Gleason score7 cancers(p Z 0.005).mpMRI sensitivity,specificity,positive and negative predictive values were 84%,39%,81%,and 44% respectively,for Gleason7 cancer.For ECE and SVI,sensitivity and specificity were 58% and 98% and 44% and 97%,respectively.Conclusion:mpMRI is an accurate predictor of TRUS biopsy and RP outcomes.mpMRI has significant potential to change PCa management,particularly in the screening population,in whom a significant proportion may avoid TRUS biopsy.Further studies are necessary to determine how mpMRI should be incorporated into the current PCa screening and staging paradigms. | Geoffrey Gaunay Vinay Patel Paras Shah Daniel Moreira Simon J.Hall Manish A.Vira Michael Schwartz Jessica Kreshover Eran Ben-Levi Robert Villani Ardeshir Rastinehad Lee Richstone | 2017 | Asian Journal of Urology2017，4，1： | 1 |
| 8 | Common chronic health problems and life satisfaction among Macao elderly people显示文摘Aim:Most elderly people live with one or more health problems and their quality of life is affected.This study aimed to compare life satisfaction of elderly people living with common chronic medical illness compared with those without these health conditions in order to identify conditions that most affect life satisfaction of elderly people living in the community.Method:The data was collected by a questionnaire survey of 529 elderly living in community dwellings of Macao using a single measure of life satisfaction and self-reported common chronic medical illness diagnosed by a physician.A purposeful stratified random sampling method was used.Independent sample t-tests were conducted to compare participants who had a health condition to those without a health condition.Results:Respondents who indicated the lowest life satisfaction were those with fracture after the age of 60,eye illness,chronic bronchitis/emphysema,and metabolic arthritis/arthritis.For men,prostate problems was also significantly related to low life satisfaction.Conclusion:Lowest life satisfaction was reported among Macao elderly people living with mobility related chronic medical illness.Policies and practices should pay more attention to mobility related health problems or issues of elderly people,such as eye health and neuromuscular weaknesses. | Sydney X.X.Hu Wai In Lei Ka Kei Chao Brian J.Hall Siu Fung Chung | 2016 | International Journal of Nursing Sciences2016，3，4： | 1 |
| 9 | INERTIA SETS OF SYMMETRIC SIGN PATTERN MATRICES显示文摘A sign pattern matrix is a matrix whose entries are from the set {+,-,0}. The symmetric sign pattern matrices that require unique inertia have recently been characterized. The purpose of this paper is to more generally investigate the inertia sets of symmetric sign pattern matrices. In particular, nonnegative tri-diagonal sign patterns and the square sign pattern with all + entries are examined. An algorithm is given for generating nonnegative real symmetric Toeplitz matrices with zero diagonal of orders n≥3 which have exactly two negative eigenvalues. The inertia set of the square pattern with all + off-diagonal entries and zero diagonal entries is then analyzed. The types of inertias which can be in the inertia set of any sign pattern are also obtained in the paper. Specifically, certain compatibility and consecutiveness properties are established. | Frank J.Hall Li 李忠尚 | 2001 | Numerical Mathematics A Journal of Chinese Universities(English Series)2001，10，2： | 0 |
| 10 | Osborne矿的水砂充填试验显示文摘该矿在检查了发生于1999年7月和2000年元月的两次充填隔墙破坏后恢复了水砂充填作业,检查表明以下因素可能促使隔墙破坏:充填料排水性能不良,不适当的砂浆进一步妨碍了不足的排水能力,两堵隔墙在作业中可能受到损坏,以及此种充填条件的隔墙设计不当.文章讨论了该矿的水砂充填工艺规程,描述了导致隔墙破坏的主要问题以及对充填工艺规程所作的改进和目前的充填结果.确定了今后充填工程必须考虑的一些主要问题:(1)隔墙设计:应用适当的安全系数进行数字模拟;建筑质量(砖和灰浆);(2)隔墙数:排水区要与待充填空区的容量与形状以及充填速率相适应;使排水通道最少;(3)充填料规格:充填料颗粒物的粒径级配;浆体稠密度;充填策略;(4)采场情况的分析:充填与排水的计算机模拟,以预测采场中水与充填料的高度;采场经过隔墙排水的测量;(5)安全检查:隔墙与围岩的定期检查;隔墙的保护等.该矿自2003年8月末重新开始充填后,现行的作法是监控这些区域并相应地调整充填速率. | J.Hall 刘维震 | 2004 | 矿业研究与开发2004，24，z1： | 0 |
| 11 | 盐体型式的复杂性和凝缩段的生长显示文摘路易斯安那大陆架上墨西哥湾盐下远景区带比人们最初所想象的更复杂。只有对解决深度成像和钻井问题作好充分准备,才能成功地进行盐下勘探。 | Robert O.Brooks Dr.David J.Hall 陈旻 | 1997 | 国外油气勘探1997，9，2： | 0 |
| 12 | ATM与BRCA1的双杂合性通过影响若干通路增加肿瘤发生风险显示文摘目的:流行病学统计数据表明杂合性与肿瘤发生相关。ATM和BRCA1都是DNA损伤修复通路中的多功能基因,其单杂合性对于肿瘤易感性的影响已见报道。 | 胡文涛 苏锋涛 Lubomir B.Smilenov 周利斌 朱佳赟 丁楠 刘苑辛 高清祥 Tom K.Hei Eric J.Hall 周光明 | 2009 | 生物物理学报2009，0，S1： | 0 |
| 13 | 适用于锂氧电池的高容量碳基电极(英文)显示文摘以碳酸钠为催化剂,将间苯二酚与甲醛进行缩聚,所生成的气凝胶在800℃的惰性气氛中进行碳化以制备多孔的碳气凝胶。碳的多孔质地由改变凝胶前体中间苯二酚与催化剂的摩尔比来调节,摩尔比的范围为100-500。气凝胶和碳气凝胶的多孔结构以住绝对温度77K下进行的氮气的吸附-解吸附测量结果表征。已经发现,总孔隙度和碳的平均孔径随着凝胶前体的摩尔比的增加而增大。作为一种活性材料,碳气凝胶用于制造合成碳电极。合成碳电极的电化学性能以将其用作锂/氧电池的负极来进行测试。由静电充放电测量发现,随着摩尔比的增加,由碳气凝胶制造的锂/氧电池的比容量由716mA·h·g^-1增加到2077mA·h·g^-1。所得到的最初10次充/放电循环的电压分布图表明,这些碳样品具有出色的循环稳定性。 | Mojtaba Mirzaeian Peter J.Hall | 2007 | 电网技术2007，31，20： | 0 |
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