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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Gallbladder tuberculosis: False-positive PET diagnosis of gallbladder cancer显示文摘Gallbladder tuberculosis (GT) is an extremely rare disease, and very few cases have been reported in the literature. The first case of GT was described in 1870 by Gaucher. A correct preoperative diagnosis of GT is unusual, and it is frequently confused with various gallbladder diseases. We present a new case of a patient who underwent surgery with the preoperative diagnosis of gallbladder cancer after a false positive positron emission tomography scan in the diagnostic work-up. | JM Ramia K Muffak A Fernández J Villar D Garrote JA Ferron | 2006 | World Journal of Gastroenterology2006，12，40： | 5 |
| 4 | Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study显示文摘 | Nicholas P West Eva JA Morris Olorunda Rotimi Alison Cairns Paul J Finan Philip Quirke | 2008 | Lancet Oncology2008，，9： | 4 |
| 5 | Embryonic stem cell lines derived from human blastocysts显示文摘 | Thomson JA Itskovitz Eldor J Shapiro SS | | 0，，： | 3 |
| 6 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 7 | Vasopressin versus norepinephrine infusion in patients with septic shock显示文摘 | Russell JA Walley KR Singer J | | 0，，09： | 2 |
| 8 | Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis显示文摘 | Ward J Guthrie JA Scott DJ | 2000 | Radiology2000，216，1： | 2 |
| 9 | 左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究显示文摘确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法:随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁, | 刘莉 叶鹏 Kloch-Badelek M Knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA Kuznetsova T | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 10 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 11 | Developments in diagnosis and treatment of paediatric septic arthritis显示文摘Acute septic arthritis in children is an orthopaedic emergency.A delay in diagnosis and inappropriate treatment can result in devastating damage to the joint with lifelong disability as a consequence.The clinical presentation can be a diagnostic challenge,especially in young children.A recent systematic review showed that joint tenderness and fever are important signals of septic arthritis.Ultrasound is helpful in detecting the presence of a joint effusion.Plain radiographs may show bone changes but magnetic resonance imaging is the most reliable imaging study for detecting concomitant osteomyelitis.The diagnosis of acute septic arthritis is highly suggestive when pus is aspirated from the joint,in case of a positive culture or a positive gram stain of the joint fluid,or if there is a white blood-cell count in the joint fluid of more than 50000/mm3.Staphylococcus aureus is the most commonly cultured organism.Recent systematic reviews have identified the most effective drainage techniques,including needle aspiration,arthroscopy and arthrotomy,depending on the affected joint.After the drainage procedure it is important to monitor the clinical and laboratory outcomes.Additional drainage procedures may be necessary in select cases. | Cornelia M Donders Anne J Spaans Herbert van Wering Christiaan JA van Bergen | 2022 | World Journal of Orthopedics2022，13，2： | 2 |
| 12 | Angiopoietins 3 and 4:Diverging gene counter part sin mice and humans显示文摘 | Valenzuela DM Griffiths JA Rojas J | 1999 | Proc Natl Acad Sci USA1999，96，5： | 2 |
| 13 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 14 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 15 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 16 | No-reflow during coronary intervention :observations and implications 显示文摘 | Leopold JA Berger C J Cupples LA | 2000 | Circulation2000，102，： | 2 |
| 17 | Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization 显示文摘 | Luk C Tsao M- S Bayani J Shepherd F Squire JA | 2001 | Cancer Genetics and Cytogenetics2001，125，： | 1 |
| 18 | Targeted gene expression in dopamine and serotonin neurons of the mouse brain 显示文摘 | Zhuang X Masson J Gingrich JA | 2005 | J Neurosci Methods2005，143，1： | 1 |
| 19 | Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin 显示文摘 | Choi JA Kim J Y Lee JY | 2001 | Int J Oncol2001，19，4： | 1 |
| 20 | Simultaneous determination of paracetamol and chlorpheniramine in human plasma by liquid choramatophy - tandem mass spectrometry 显示文摘 | Celma C Allue JA Prunonosa J | 2000 | J Chromatogr A2000，870，： | 1 |
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