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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Determination of morphine and related alkaloids in crude morphine , poppy straw and opium preparations by micellar electrokinetic capil-lary chromatography显示文摘 | TRENERRY C V ROBERT J W JAMES R | 1995 | Journal of Chromatography A1995，，718： | 1 |
| 3 | A Unique Clonal JAK2 Mutation Leading to Constitutive Signaling Causes Polyeythaemia Vera显示文摘 | James C Ugo V Couedic J P I | 2005 | Nature2005，434，7037： | 1 |
| 4 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | JAME C UGO V LE COUEDIC J P | 2005 | Nature2005，434，： | 1 |
| 5 | A unique clonal JAK2 mutation leading to constitutive signalling cau ses polycythaemia vera显示文摘 | James C Ugo V Le Couédic JP | 2005 | Nature2005，434，7037： | 1 |
| 6 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythemia vera显示文摘 | James C Ugo V Le Couedic JP | | 0，，： | 1 |
| 7 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | JAMES C UGO V LECOUEDIC J P | 2005 | Nature2005，434，： | 1 |
| 8 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera显示文摘 | James C Ugo V Le Couedic JP | 2005 | Nature2005，434，7037： | 1 |
| 9 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera显示文摘 | James C Ugo V Lecouedic JP | 2005 | Nature2005，434，7037： | 1 |
| 10 | Recombinant human osteogenic protein(hOP-1 ) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differenation in vitro 显示文摘 | Sampath TK James C Peter V | 1992 | J Biol Chem1992，267，20： | 1 |
| 11 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | UGO V Le COUEDIC JP | 2005 | Nature2005，434，： | 1 |
| 12 | An event-based architecture definition language显示文摘 | Luckham D C James V | 1995 | IEEE Trans on Software Engineering1995，21，9： | 1 |
| 13 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 14 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera 显示文摘 | James C Ugo V Le CJP | 2005 | Nature2005，434，7037： | 1 |
| 15 | Outcome analysis of noninstrumented anterior cervical discectomy and interbody fusion in 348 patients 显示文摘 | Richard K James V | 1998 | Spine1998，23，2： | 1 |
| 16 | Effect of ErbB2 Coexpression on the Kinetic Interactions of Epidermal Growth Factor with Its Receptor in Intact Cells 显示文摘 | John C Wilkinson James V | 2002 | Biochemistry2002，41，1： | 1 |
| 17 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera 显示文摘 | James C Ugo V Le Cou6dic JP | 2005 | Nature2005，434，7037： | 1 |
| 18 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera 显示文摘 | James C Ugo V Couedic JPL | 2005 | Nature2005，434，7037： | 1 |
| 19 | Improved sense-amplifier-based flip-flop:Design and measurements显示文摘 | NIKOLIC B OKLOBDZIJA V G STOJANOVIC V JIA W Y JAMES K C MING-TAK L M | 2000 | IEEE Journal of Solid-State Circuits2000，35，6： | 1 |
| 20 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | James C Ugo V Le Couedic JP | 2005 | Nature2005，434，7037： | 1 |
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