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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Long term effect of alpha interferon in children with chronic hepatitis B显示文摘 | Bortolotti F Jara P Barbera C et at | 2000 | Gut2000，46，5： | 1 |
| 3 | Selenium improves the antioxidant ability against aluminium-induced oxidative stress in ryegrass roots 显示文摘 | Cartes P Jara A Pinilla L | 2010 | Annals of Applied Biology2010，156，2： | 1 |
| 4 | Rational approximation schemes for bi-continuous semigroups显示文摘 | Jara P | 2008 | J Math Anal Appl2008，344，： | 1 |
| 5 | Catalytic materials for high-temperature combustion显示文摘 | JARAS S G MENON P G | 1993 | Catal Rev Sci Eng1993，35，3： | 1 |
| 6 | Rational approximation schemes for hi-continuous semigroups显示文摘 | JARA P | 2008 | Journal of Mathematical Analysis and Applications2008，344，2： | 1 |
| 7 | Visual and non-visual factors associated with patient satisfaction and quality of life in LASIK显示文摘 | Lazon de la Jara P Erickson D Erickson P | 2011 | Eye(Lond)2011，25，9： | 1 |
| 8 | Hereditary and formally smooth coalgebras显示文摘 | JARA P LLENA D MERINO L | 2005 | Algebr Represent Theory2005，8，： | 1 |
| 9 | Interpretation of the Tidal Residuals during the July 11, 1991 Total Solar Eclipse显示文摘 | Ducarme B Sun Hc P d'Oreye N van Ruymbeke M and Mena Jara J | 1999 | Journal of Geodesy1999，73，： | 1 |
| 10 | Recurrence of bile salt export pump deficiency after liver transplantation 显示文摘 | Jara P Hierro L Martinez-Fernandez P | 2009 | N Engl J Med2009，361，14： | 1 |
| 11 | Prime path coalgebras显示文摘 | JARA P MERINO L NAVARRO G | 2008 | The Arabian Journal for Science and Engineering2008，33，2： | 1 |
| 12 | Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: randomised European multicentre trial显示文摘 | Kelly D Jara P Rodeck B | 2004 | Lancet2004，364，9439： | 1 |
| 13 | Current problems in the prevention and treamt of infe ctions in patients with cirrhosis 显示文摘 | Bellot P Jara Perez Lopez N Martines Moreno B | 2010 | Gastroenterol Hepatol2010，，： | 1 |
| 14 | Risk factors of systemic lupus erythematosus flares during pregnancy 显示文摘 | Jara L J Medina G Cruz-Dominguez P | 2014 | Immunol Res2014，60，23： | 1 |
| 15 | Lymphoblastoid interferon alfa with or without steroid pretreatment in children with chronic hepatitis B:a multicenter controlled trial显示文摘 | Gregorio GV Jara P Hierro L | 1996 | Hepatology1996，23，4： | 1 |
| 16 | Rational approximation schemes for bi-continuous semigroups显示文摘 | JARA P | 2008 | Journal of Mathematical Analysis and Applications2008，344，： | 1 |
| 17 | Rational approximation schemes for bi-continuous semigroups 显示文摘 | JARA P | 2008 | J Math Analysis Appl2008，344，2： | 1 |
| 18 | Genetic variants inFGFR2 and MAP3K1 are associated with the risk of familial andearly-onset breast cancer in a South-American population显示文摘 | Jara L Gonzalez-Hormazabal P Cerceno K | 2013 | BreastCancer Res Treat2013，137，2： | 1 |
| 19 | Catalytic material for high-temperature combustion显示文摘 | Seven G Jaras P Goving Menon | 1993 | Catal Rev-Sci and Eng1993，35，3： | 1 |
| 20 | Rational approximation schemes for bi-continuous semigroups显示文摘 | JARA P | 2008 | Journal of Mathematical Analysis and Applications2008，344，： | 1 |
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