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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Association of interleukin-1 polymor- phisms with aggressive periodontitis 显示文摘 | Quappe L Jara L Lopez NJ | 2004 | J Periodontol2004，75，： | 1 |
| 3 | Selenium improves the antioxidant ability against aluminium-induced oxidative stress in ryegrass roots 显示文摘 | Cartes P Jara A Pinilla L | 2010 | Annals of Applied Biology2010，156，2： | 1 |
| 4 | Prolactin (PRL) and interleukin-6(IL-6) in the cerebrospinal fluid(CSF) of patients with systemic lupus erythematosus and central nervous system involvement (CNSSLE)显示文摘 | Jara U Zazueta B ldgoyen L | 1993 | Arthlitis Rheum1993，362，： | 1 |
| 5 | Accelerated atherosclerosis, immune response and autoimmune rheumatic diseases 显示文摘 | Jara L J Medina G Vera-Lastra O | 2006 | Autoimmun Rev2006，5，3： | 1 |
| 6 | Association of interleukin-1 polymorphisms with aggressive periodontitis 显示文摘 | Quappe L Jara L Lopez NJ | 2004 | J Periodontol2004，75，11： | 1 |
| 7 | RAD51 135GC polymorphism and risk of familial breast cancer in a south american population显示文摘 | Jara L Acevedo ML Blanco R | 2007 | Cancer Genet Cytogenet2007，178，1： | 1 |
| 8 | Ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis显示文摘 | López-García JS Rivas Jara L García-Lozano CI | | 0，，： | 1 |
| 9 | Polymorphisms in cytochromes P4502C8 and 3A5 are associated with paclitaxel neurotoxicity 显示文摘 | Leskel S Jara C Leandro-Garcia L | 2010 | PharmacogenoaticsJ2010，11，2： | 1 |
| 10 | Ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis显示文摘 | Lepez-Garcta JS Rivas Jara L Garcfa-Lozano CI | 2011 | Ophthalmology2011，118，2： | 1 |
| 11 | Polymorph- isms in cytochromes P450 2c8 and 3A5 are associated with paclitaxel neurotoxieity显示文摘 | Leskela S Jara C Leandro-Garcia L J | 2011 | Pharmacogenomics J2011，11，2： | 1 |
| 12 | Oral hygiene and gingival health in Flemish pre-school children显示文摘 | LEROY R JARA A MARTENS L | | 0，，01： | 1 |
| 13 | Hereditary and formally smooth coalgebras显示文摘 | JARA P LLENA D MERINO L | 2005 | Algebr Represent Theory2005，8，： | 1 |
| 14 | Recurrence of bile salt export pump deficiency after liver transplantation 显示文摘 | Jara P Hierro L Martinez-Fernandez P | 2009 | N Engl J Med2009，361，14： | 1 |
| 15 | Prime path coalgebras显示文摘 | JARA P MERINO L NAVARRO G | 2008 | The Arabian Journal for Science and Engineering2008，33，2： | 1 |
| 16 | Risk factors of systemic lupus erythematosus flares during pregnancy 显示文摘 | Jara L J Medina G Cruz-Dominguez P | 2014 | Immunol Res2014，60，23： | 1 |
| 17 | Lymphoblastoid interferon alfa with or without steroid pretreatment in children with chronic hepatitis B:a multicenter controlled trial显示文摘 | Gregorio GV Jara P Hierro L | 1996 | Hepatology1996，23，4： | 1 |
| 18 | Genetic variants inFGFR2 and MAP3K1 are associated with the risk of familial andearly-onset breast cancer in a South-American population显示文摘 | Jara L Gonzalez-Hormazabal P Cerceno K | 2013 | BreastCancer Res Treat2013，137，2： | 1 |
| 19 | Association of interleukin- 1 polymor- phisms with periodontal disease显示文摘 | L6pez N J Jara L Valenzuela CY | 2005 | J Periodontol2005，76，2： | 1 |
| 20 | Eficacy and salty of peginterferon alpha 2b and ribavirin combination therapy in children with chronic hepatitis C infection 显示文摘 | JARA P HIERRO L DE LA VEGA A | 2008 | Peditric Infect Dis J2008，27，2： | 1 |
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