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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 3 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 4 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 5 | Definitive ab initio studies of model SN2 reactions CH3X+F-(X=F,Cl,OH,SH,NH2,PH2) 显示文摘 | JASON M G CHAEHO P COX R S | 2003 | Chem Eur J2003，9，： | 1 |
| 6 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 7 | Finite element analysis of the vibratory characteristics of cylindrical shells conveying fluid 显示文摘 | Zhang Yongliang Reese Jason M Gorman Daniel G | 2002 | Computer Methods in Applied Mechanics and Engineering2002，191，45： | 1 |
| 8 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 9 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 10 | Characterization of Macropore Flow Mechanisms in Soil by Means of a Split Macropore Column显示文摘 | MADOUD G M ICHAELC Y JASON C | 1999 | Soil Science Society1999，63，2： | 1 |
| 11 | 3,4-Dihydropyri- midin-2 ( 1 H) -ones positive modulation of ~-subunit-eon- raining y-aminobutyrie acid type a receptors,including an epilepsy-link ed mutant variant 显示文摘 | RYAN W L JOHN M JASON G | 2010 | Bioehernistry2010，49，23： | 1 |
| 12 | Emeishan large igneous province,SW China显示文摘 | Jason R A Thompson G M Zhou Meifu | 2005 | Lithos2005，79，： | 1 |
| 13 | Lessons learned from the design, fabrication, integration, and test of a cryogenic IR spectrometer for ground-based astronomy 显示文摘 | Jason Hylan Leroy M Sparr Raymond G Ohl | 2003 | Proceedings of SPIE(S0277-786X)2003，5172，： | 1 |
| 14 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression 显示文摘 | Jason M Archana Sud G eoffery C | 2003 | Gastroenterology2003，125，： | 1 |
| 15 | Quenching dynamics of the photoluminescence of2+-pendant PAMAM dendrimers by nitro aromatics and other materials显示文摘 | Samantha G Jason A B Nelson M | 2003 | Macromolecules2003，36，： | 1 |
| 16 | Autonomous mobile robot global motion planning and geometric beacon collection using transversability vectors显示文摘 | Janet Jason A R C Luo M G Kay | 1997 | IEEE Transactions on Robotics and Automation1997，13，1： | 1 |
| 17 | Predicting the thermal conductivity of multiple carbon fillers in polypropylene-based resins显示文摘 | Daniel L G Jason M K Na M | 2011 | Journal of Composite Materials2011，45，12： | 1 |
| 18 | Impact of radial artery cannulation for coronary angiography and angioplasty on radial artery function显示文摘 | JASON M DOMINICA G STUART J | 2007 | Am J Cardiol2007，99，： | 1 |
| 19 | Effect of fibroblast donor cell age and cell cycle on development of bovine nuclear transfer embryos in vitro 显示文摘 | Poothapillai K Jason G K Pedro N M | 2001 | Biology of Reproduction2001，64，： | 1 |
| 20 | Passive suspensions incorporating inerters for railway vehicles 显示文摘 | JASON ZHENG JIANG ALEJANDRA Z MATAMOROS R M G | 2012 | Vehicle System Dynamics2012，50，： | 1 |
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