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| 1 | 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway显示文摘桅杆房间是在免疫球蛋白(Ig ) 的重要受动器房间电子 mediated 过敏反应象气喘,遗传性过敏症的皮炎和鼻炎那样。香子兰的酸,一个自然产品,显示出抗氧化剂和反煽动性的活动。在现在的学习,我们调查了 ortho 香子兰的酸的反过敏的煽动性的效果(2-hydroxy-3-methoxybenzoic 酸,卵) 那是从 Amomum xanthioides 孤立的香子兰的酸的衍生物。在老鼠过敏性模型,卵的口头的管理(2, 10, 50 mg/kg ) dose-dependently 稀释了象降低体温,组织安版本, IgE 生产和 vasodilation 那样的导致 ovalbumin 的活跃全身的过敏性和调停 IgE 的皮肤的过敏反应;卵的管理也压制了桅杆房间 degranulator 混合物 48/80-induced 过敏性。在在 vitro 的有教养的桅杆房间线 RBL-2H3 和孤立的老鼠腹桅杆房间,有卵(1-100 mol/L ) 的预告的处理 dose-dependently 由减少禁止了桅杆房间的 DNP-HSA-induced degranulation 细胞内部的免费的钙水平,并且压制了支持 inflammatory cytokines TNF-4 和 IL-4 的表示。有卵的 RBL-2H3 房间的预告的处理压制了 Lyn, Syk, Akt,和原子 factor-B 的原子 translocation 的 DNP-HSA-induced phosphorylation。在结论,卵压制桅杆由在桅杆房间的表面上高亲密关系 IgE 受体(FcRI ) 下游地堵住发信号的小径的调停房间的过敏煽动性的反应。 | Yeon-Yong KIM In-Gyu JE Min Jong KIM Byeong-Cheol KANG Young-Ae CHOI Moon-Chang BAEK Byungheon LEE Jin Kyeong CHOI Hae Ran PARK Tae-Yong SHIN Soyoung LEE Seung-Bin YOON Sang-Rae LEE Dongwoo KHANG Sang-Hyun KIM | 2017 | Acta Pharmacologica Sinica2017，38，1： | 8 |
| 2 | Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis显示文摘AIM:To evaluate the effect of exogenous recombinant human bone morphogenic protein-7(rhBMP-7)on transforming growth factor-β(TGF-β)-induced epithelial mesenchymal cell transition(EMT)and assessed its antifibrotic effect via topical application.METHODS:The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells(HECEs)was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid(HA). EMT markers,fibronectin,E-cadherin,α-smooth muscle actin(α-SMA),and matrix metaloproteinase-9(MMP-9),were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of rhBMP-7.RESULTS:Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion(31.6%; P<0.05),the α-SMA protein level(72.2%; P<0.01),and MMP-9 expression(23.6%,P<0.05)in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced(289.7%; P<0.01)in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA^+ cells by 43.18%(P<0.05)at a concentration of 2.5 μg/mL and by 47.73%(P<0.05)at 25 μg/mL,compared with the control group,without disturbing corneal reepithelization.CONCLUSION:rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders. | Jin Kwon Chung Shin Ae Park Hee Sun Hwang Kwang Sung Kim Yang Je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 3 |
| 3 | Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes显示文摘In the present study,we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats.To induce hypothyroidism,Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole,an anti-thyroid drug,treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining.In the methimazole-treated Zucker lean control and Zucker diabetic fatty rats,the serum circulating triiodothyronine(T3)and thyroxine(T4)levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats.This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group.Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1(Iba-1)-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus.There were no significant differences in the glial fibrillary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups.However,in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups,the processes of glial fibrillary acidic protein immunoreactive astrocytes and Iba-1 immunoreactive microglia,were significantly decreased in both the CA1region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups.These results suggest that diabetes has no effect on the morphology of astrocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia. | Sung Min Nam Yo Na Kim Dae Young Yoo Sun Shin Yi Jung Hoon Choi In Koo Hwang Je Kyung Seong Yeo Sung Yoon | 2013 | Neural Regeneration Research2013，8，26： | 2 |
| 4 | Analysis of voice and quantitative measurement of glottal gap after thyroplasty type Ⅰ in the treatment of unilateral vocal paralysis 显示文摘 | Shin JE Nam SY Yoo SJ | 2002 | Journal of Voice2002，16，1： | 1 |
| 5 | Influence of thresholds on amplitudesin vestibular evoked myogenic potentials显示文摘 | Shin JE Kim CH Park HJ | 2013 | Auris Nasus Larynx2013，40，4： | 1 |
| 6 | Degradation of methylene blue via photocatalysis of titanium dioxide显示文摘 | Chul Han Kwon Hyunmin Shin Je Hun Kim | 2004 | Materials Chemistry and Physics2004，86，： | 1 |
| 7 | The effect of canalith repositioning for anterior semicircular canal canalithiasis 显示文摘 | Kim YK Shin JE Chung JW | 2005 | ORL J Otorhinolaryngol Relat Spec2005，67，1： | 1 |
| 8 | Bronchopulmonary dysplasia: new high resolution computed tomography scoring system and correlation between the high resolution computed tomo- graphy score and clinical severity显示文摘 | Shin SM Kirn WS Cheon JE | 2013 | Korean J Radiol2013，14，2： | 1 |
| 9 | Intracellular degradation of Fuso- bacterium nucleatum in human gingival epithelial cells显示文摘 | Ji S Shin JE Kim YC | 2011 | Mol Ceils2011，30，6： | 1 |
| 10 | Intraviteal bevacizumab injection as preoperative adjuvant of vitrectomy for proliferative diabetic retinopathy显示文摘 | Shin MK Kim NM Lee JE | 2009 | J Korean Ophthalmol Soc2009，50，5： | 1 |
| 11 | Analysis of voice and quantitative measurement of glottal gap after thyroplasty type Ⅰ in the treatment of unilateral vocal paralysis显示文摘 | Shin JE Nam SY Yoo SJ | 2002 | J Voice2002，16，1： | 1 |
| 12 | The comparison of vitamin C and vitamin E on the protein oxidation of diabetic rats显示文摘 | Je HD Shin CY Park HS | 2001 | J Auton Pharmacol2001，21，56： | 1 |
| 13 | Enhanced osteoclastogene- sis in 4-1BB-deficient mice caused by reduced interleukin 10 显示文摘 | Shin HH Lee JE Lee EA | 2006 | J Bone Miner Res2006，21，12： | 1 |
| 14 | Tumor necrosis factor gone polymor- phisms in Korean patients with recurrent spontaneous abortion显示文摘 | Lee BE Jeon YJ Shin JE | 2013 | Re- prod Sci2013，20，4： | 1 |
| 15 | Inner ear anomalies in cochlear implantees: importance of radiologic measurements in the classification 显示文摘 | Shim H J Shin JE Chung JW | 2006 | Otol Neurotol2006，27，6： | 1 |
| 16 | Degradation of methylene blue via photocatalysis of titanium dioxide显示文摘 | Chul Han Kwon Hyunmin Shin Je Hun Kim | 2004 | Materials Chemistry and Physics2004，86，1： | 1 |
| 17 | CT in children with suspected residualforeign body in airway after bronchoscopy显示文摘 | Shin SM Kim WS Cheon JE | 2009 | AJR2009，192，6： | 1 |
| 18 | Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells显示文摘 | Ji S Shin JE Kim YS | 2009 | Infect Immun2009，77，3： | 1 |
| 19 | Prospective study of C-reactive protein and the risk of future cardiovascular events among apparent healthy women显示文摘 | Ridker PM Buring JE Shin J | 1998 | Circulation1998，98，8： | 1 |
| 20 | DehaNp63ct protein triggers epithelial- mesenchymal transition and confers stem cell properties in normal human keratinocytes显示文摘 | Oh JE Kim RH Shin KH | 2011 | Biol Che2011，286，38： | 1 |
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