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| 1 | Long-term follow up of endoscopic resection for type 3 gastric NET显示文摘AIM:To clarify the short and long-term results and to prove the usefulness of endoscopic resection in type 3gastric neuroendocrine tumors(NETs).METHODS:Of the 119 type 3 gastric NETs diagnosed from January 1996 to September 2011,50 patients treated with endoscopic resection were enrolled in this study.For endoscopic resection,endoscopic mucosal resection(EMR)or endoscopic submucosal dissection(ESD)was used.Therapeutic efficacy,complications,and follow-up results were evaluated retrospectively.RESULTS:EMR was performed in 41 cases and ESD in 9 cases.Pathologically complete resection was performed in 40 cases(80.0%)and incomplete resection specimens were observed in 10 cases(7 vs 3 patients in the EMR vs ESD group,P=0.249).Upon analysis of the incomplete resection group,lateral or vertical margin invasion was found in six cases(14.6%)in the EMR group and in one case in the ESD group(11.1%).Lymphovascular invasions were observed in two cases(22.2%)in the ESD group and in one case(2.4%)in the EMR group(P=0.080).During the follow-up period(43.73;13-60 mo),there was no evidence of tumor recurrence in either the pathologically complete resection group or the incomplete resection group.No recurrence was reported during follow-up.In addition,no mortality was reported in either the complete resection group or the incomplete resection group for the duration of the follow-up period.CONCLUSION:Less than 2 cm sized confined submucosal layer type 3 gastric NET with no evidence of lymphovascular invasion,endoscopic treatment could be considered at initial treatment. | Yong Hwan Kwon Seong Woo Jeon Gwang Ha Kim Jin Il Kim Il-Kwun Chung Sam Ryong Jee Heung Up Kim Geom Seog Seo Gwang Ho Baik Kee Don Choi Jeong Seop Moon | 2013 | World Journal of Gastroenterology2013，19，46： | 14 |
| 2 | Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence显示文摘BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is questionable.Artificial intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after PD.AIM To develop a risk prediction platform for POPF using an AI model.METHODS Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven algorithms.The algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing values.The area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF prediction.RESULTS The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition 2016.After median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with NN.The maximal AUC using NN with RFE was 0.74.Sixteen risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary decompression.We developed a web-based POPF prediction platform,and this application is freely available at http://popfrisk.smchbp.org.CONCLUSION This study is the first to predict POPF with multiple risk factors using AI.This platform is reliable(AUC 0.74),so it could be used to select patients who need especially intense therapy and to preoperatively establish an effective treatment strategy. | In Woong Han Kyeongwon Cho Youngju Ryu Sang Hyun Shin Jin Seok Heo Dong Wook Choi Myung Jin Chung Oh Chul Kwon Baek Hwan Cho | 2020 | World Journal of Gastroenterology2020，26，30： | 12 |
| 3 | Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization显示文摘·AIM: To evaluate whether trapping vascular endothelial growth factor-A(VEGF-A) would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture model.·METHODS: We established two groups of animals, one with non-dry eyes and the other with induced dry eyes.In both groups, a corneal suture model was used to induce inflammation and neovascularization. Each of two groups was again divided into three subgroups according to the treatment; subgroup I(aflibercept),subgroup II(dexamethasone) and subgroup III(phosphate buffered saline, PBS). Corneas were harvested and immunohistochemical staining was performed to compare the extents of neovascularization and CD11b+ cell infiltration. Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and VEGF-A in the corneas.·RESULTS: Trapping VEGF-A with aflibercept resulted in significantly decreased angiogenesis and inflammation compared with the dexamethasone and PBS treatments in the dry eye corneas(all P <0.05), but with no such effects in non-dry eyes. The anti-inflammatory and antiangiogenic effects of VEGF-A trapping were stronger than those of dexamethasone in both dry eye and non-dry eye corneas(all P <0.05). The levels of RNA expression of VEGF-A, TNF-alpha, and IL-6 in the aflibercept subgroup were significantly decreasedcompared with those in the PBS subgroup in the dry eye group.·CONCLUSION: Compared with non-dry eye corneas,dry eye corneas have greater amounts of inflammation and neovascularization and also have a more robust response to anti-inflammatory and anti-angiogenic agents after ocular surface surgery. Trapping VEGF-A is effective in decreasing both angiogenesis and inflammation in dry eye corneas after ocular surface surgery. | Jin Woo Kwon Jin A Choi Eun Young Shin Tae Yoon La Dong Hyun Jee Yeon Woong Chung Yang Kyung Cho | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 5 |
| 4 | Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model显示文摘AIM: To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration,neovascularization(NV) and lymphangiogenesis(LY)between the dry eye and non-dry eye in murine cataract surgery models.·METHODS: We established two groups of animals, one with normal eyes(non-dry eye) and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture.After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b+ cell infiltration in the corneas.· RESULTS: Dry eye group had significantly more inflammatory infiltration(21.75%±7.17% vs 3.65%±1.49%;P =0.049). The dry eye group showed significantly more NV(48.21% ±4.02% vs 26.24% ±6.01%; P =0.016) and greater levels of LY(9.27%±0.48% vs 4.84%±1.15%; P =0.007). In corneas on which no surgery was performed,there was no induction of NV in both the dry and non-dry group, but dry eye group demonstrated more CD11b+cells infiltration than the non-dry eye group(0.360% ±0.160% vs 0.023% ±0.006%; P =0.068). Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection(P =0.020 and 0.000, respectively).·CONCLUSION: In a murine cataract surgery model,preexisting dry eye can induce more postoperative NV,LY, and inflammation in corneal tissue. | Jin Woo Kwon Yeon Woong Chung Jin A Choi Tae Yoon La Dong Hyun Jee Yang Kyung Cho | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 5 |
| 5 | Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis显示文摘AIM:To evaluate the effect of exogenous recombinant human bone morphogenic protein-7(rhBMP-7)on transforming growth factor-β(TGF-β)-induced epithelial mesenchymal cell transition(EMT)and assessed its antifibrotic effect via topical application.METHODS:The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells(HECEs)was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid(HA). EMT markers,fibronectin,E-cadherin,α-smooth muscle actin(α-SMA),and matrix metaloproteinase-9(MMP-9),were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of rhBMP-7.RESULTS:Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion(31.6%; P<0.05),the α-SMA protein level(72.2%; P<0.01),and MMP-9 expression(23.6%,P<0.05)in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced(289.7%; P<0.01)in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA^+ cells by 43.18%(P<0.05)at a concentration of 2.5 μg/mL and by 47.73%(P<0.05)at 25 μg/mL,compared with the control group,without disturbing corneal reepithelization.CONCLUSION:rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders. | Jin Kwon Chung Shin Ae Park Hee Sun Hwang Kwang Sung Kim Yang Je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 3 |
| 6 | Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27显示文摘Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA. | Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun Yoo | 2018 | Bone Research2018，6，3： | 3 |
| 7 | Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study显示文摘 | Min Kim Seong Woo Jeon Kwang Bum Cho Kyung Sik Park Eun Soo Kim Chang Keun Park Hyang Eun Seo Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Byeong Ik Jang Si Hyung Lee Kyeong Ok Kim Chang Hun Yang | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 8 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 9 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 10 | Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice显示文摘 | Jae Hyun Park Jong Kwon Lee Hyung Soo Kim Seung Tae Chung Juno H. Eom Kyung A. Kim Se Jin Chung Soon Young Paik Hye Young Oh | 2004 | International Immunopharmacology2004，，3： | 2 |
| 11 | Ten‐day sequential versus triple therapy for H elicobacter pylori eradication: A prospective, open‐label, randomized trial显示文摘 | Jun‐Won Chung Young Kul Jung Yoon Jae Kim Kwang Ahn Kwon Jung Ho Kim Jong Joon Lee Sung Min Lee Ki Baik Hahm Sun Mi Lee Jin Yong Jeong Sung‐Cheol Yun | 2012 | J Gastroenterol Hepatol2012，，11： | 2 |
| 12 | Incidence of Propofol Injection Pain and Effect of Lidocaine Pretreatment During Upper Gastrointestinal Endoscopy显示文摘 | Ji Suk Kwon Eun Soo Kim Kwang Bum Cho Kyung Sik Park Woo Young Park Jeong Eun Lee Tae Yol Kim Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2012 | Digestive Diseases and Sciences2012，，5： | 1 |
| 13 | Hemorrhagic hemangioma in the liver:A case report显示文摘Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-yearold woman who was admitted with epigastric pain.She had taken oral contraceptives several weeks prior.The results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor properties and control the hemorrhage. The pathologic findings of the resected mass were consistent with hepatic hemangioma with intratumoral hemorrhage. The patient was discharged 8 d after the surgery, without further complications or complaints, and the patient's condition was found to have improved during follow-up. | Jeong Min Kim Woo Jin Chung Byoung Kuk Jang Jae Seok Hwang Yong Hoon Kim Jung Hyeok Kwon Mi Sun Choi | 2015 | World Journal of Gastroenterology2015，21，23： | 1 |
| 14 | Factors Affect on the Reaction Performance of the Oxidative Dehydrogenation of n-Butene to 1,3-Butadiene Over Zn-Ferrite Catalysts显示文摘 | Young-Min Chung Yong-Tak Kwon Tae Jin Kim | | 0，，3： | 1 |
| 15 | Outcome and predictors of mortality in patients requiring invasive mechanical ventilation due to acute respiratory failure while undergoing ambulatory chemotherapy for solid cancers显示文摘 | So Young Park So Yeon Lim Sang-Won Um Won-Jung Koh Man Pyo Chung Hojoong Kim O Jung Kwon Hye Kyeong Park Seok Jin Kim Young Hyuck Im Myung-Ju Ahn Gee Young Suh | 2013 | Supportive Care in Cancer2013，，6： | 1 |
| 16 | Clinicopathological characteristics of PIK 3 CA and HB x mutations in Korean patients with hepatocellular carcinomas显示文摘 | Dong Choon Kim Woo Jin Chung Jae‐Ho Lee Byung Kuk Jang Jae Seok Hwang Koo Jeong Kang Sun Young Kwon | 2014 | APMIS2014，，10： | 1 |
| 17 | Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle显示文摘 | Ji Hyun Han Oh Sang Kwon Jin Ho Chung Kwang Hyun Cho Hee Chul Eun Kyu Han Kim | 2004 | Journal of Dermatological Science2004，，2： | 1 |
| 18 | Isoliquiritigenin inhibits nfigration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling 显示文摘 | Gyoo Taik Kwon Hart Jin Choa Won-Yoon Chung | 2009 | Journal of Nutritional Biochemistry2009，20，： | 1 |
| 19 | Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle显示文摘 | Ji Hyun Han Oh Sang Kwon Jin Ho Chung Kwang Hyun Cho Hee Chul Eun Kyu Han Kim | 2004 | Journal of Dermatological Science2004，，2： | 1 |
| 20 | Association of MUC6 -minisatellite variants with susceptibility to rectal carcinoma显示文摘 | Myoung-Hyun Ahn Ki Beom Bae Jeong-Ah Kwon Hong-Jo Choi Se-Ra Lee Si-Hoon Kim Tae Doo Jung Sun Hee Kim Min Sung An Kwan Hee Hong Jeonghoon Heo Tae-Hong Kang Jin Woong Chung Sun-Hee Leem | 2013 | Molecular Biology Reports2013，，1： | 1 |
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