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| 1 | Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus显示文摘The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone. | Young Ae Kim Sol Lee Ji Woong Jung Yu Jin Kwon Gyeong Bok Lee Dong Gue Shin Sang Su Park Jin Yun Yong-Seog Jang Dong Hui Cho | 2014 | Chinese Journal of Cancer Research2014，26，3： | 12 |
| 2 | Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis显示文摘AIM:To evaluate the effect of exogenous recombinant human bone morphogenic protein-7(rhBMP-7)on transforming growth factor-β(TGF-β)-induced epithelial mesenchymal cell transition(EMT)and assessed its antifibrotic effect via topical application.METHODS:The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells(HECEs)was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid(HA). EMT markers,fibronectin,E-cadherin,α-smooth muscle actin(α-SMA),and matrix metaloproteinase-9(MMP-9),were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of rhBMP-7.RESULTS:Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion(31.6%; P<0.05),the α-SMA protein level(72.2%; P<0.01),and MMP-9 expression(23.6%,P<0.05)in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced(289.7%; P<0.01)in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA^+ cells by 43.18%(P<0.05)at a concentration of 2.5 μg/mL and by 47.73%(P<0.05)at 25 μg/mL,compared with the control group,without disturbing corneal reepithelization.CONCLUSION:rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders. | Jin Kwon Chung Shin Ae Park Hee Sun Hwang Kwang Sung Kim Yang Je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 3 |
| 3 | Cell type-specific STAT3 activation by gp130-related cytokines in the peripheral nerves显示文摘 | Lih Wang Hyun Kyoung Lee In Ae Seo Yoon Kyung Shin Kyu Yeol Lee Hwan Tae Park | 2009 | NeuroReport2009，，7： | 2 |
| 4 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 5 | Preparation of Y2O3 Particles by Flame Spray Pyrolysis with Emulsion显示文摘 | Shin Ae Song Kyeong Youl Jung and Seung Bin Park | 2009 | Langmuir2009，25，6： | 1 |
| 6 | Clinical features and predictors of clinical outcomes in K orean patients with C rohn’s disease: A K orean A ssociation for the S tudy of I ntestinal D iseases multicenter study显示文摘 | Chang Mo Moon Dong Il Park Eun Ran Kim Young‐Ho Kim Chang Kyun Lee Suck‐Ho Lee Jae Hak Kim Kyu‐Chan Huh Sung‐Ae Jung Soon Man Yoon Hyun Joo Song Hyun Joo Jang You Sun Kim Kang‐Moon Lee Jeong Eun Shin | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 7 | Liver X receptor mediates hepatitis B virus X protein–induced lipogenesis in hepatitis B virus–associated hepatocellular carcinoma显示文摘 | Tae‐Young Na Young Kee Shin Kyung Jin Roh Shin‐Ae Kang Il Hong Sae Jin Oh Je Kyung Seong Cheol Keun Park Yoon La Choi Mi‐Ock Lee | 2009 | Hepatology2009，，4： | 1 |
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