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| 1 | Functional Analysis of Discoidin Domain Receptor 2 in Synovial Fibroblasts in Rheumatoid Arthritis显示文摘 | Jicun Wang Houshan Lü Xinping Liu Yanchun Deng Tiezheng Sun Fuyang Li Shaoping Ji Xiaoyan Nie Libo Yao | 2002 | Journal of Autoimmunity2002，，3： | 1 |
| 2 | TGF‐β‐producing regulatory B cells induce regulatory T cells and promote transplantation tolerance显示文摘 | Kang Mi Lee Ryan T Stott Gaoping Zhao Julie SooHoo Wei Xiong Moh Moh Lian Lindsey Fitzgerald Shuai Shi Elsie Akrawi Ji Lei Shaoping Deng Heidi Yeh James F Markmann James I Kim | 2014 | Eur. J. Immunol2014，，： | 1 |
| 3 | Pseudo Rabies Virus Protein UL34 Interacted with UL31 to Disrupt the Human Lamin A显示文摘从原子核由的假狂犬病病毒(PRV ) 外出从内部原子膜(INM ) 开始发育。原子薄板形成位于 INM 下面的中间的细丝的一个僵硬网状组织。PRV 感染是否导致薄板的混乱,仍然保持未知。在这份报纸,原子 Lamin A 变得在 PRV 感染期间断裂了,这能被观察。UL34 在原子边界是局部性的,但是 UL31 作为不同补丁在原子核被积累。有趣地, UL31 的部分面对 UL34 在 INM 是局部性的。Immunoprecipitation (IP ) 试金证实了那 PRV UL31, UL34 在 transfected 房间交往了。重要地, UL31 和 UL34 的合作表示直接破坏了 Lamin A,类似于在 PRV 感染期间观察了那。在结论, PRV 感染导致 Lamin A,和 UL34 和 UL31 玩的混乱在 Lamin A 的混乱的一个关键角色。 | WEI Wenqiang HU Zichao KANG Xiaonan WANG Xuan WANG Hongju JI Shaoping | 2018 | Wuhan University Journal of Natural Sciences2018，23，5： | 1 |
| 4 | Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation显示文摘Although Sirt2 is primarily expressed in oligodendrocytes of the central nervous system,its role in oligodendroglial lineage differentiation is not fully understood.Our findings demonstrate that the transcription factor Nkx2.2 binds to the Sirt2 promoter via histone deacetylase 1(HDAC-1),the binding site for Nkx2.2 maps close to the start codon of the Sirt2 gene,and Nkx2.2 negatively regulates Sirt2 expression in CG4 cells,an oligodendroglial precursor cell line.HDAC-1 knock-down not only significantly attenuates the binding capacity of Nkx2.2 to the Sirt2 promoter but also releases repression of Sirt2 expression by Nkx2.2.Nkx2.2 overexpression down-regulates Sirt2 expression and delays differentiation of CG4 cells;in contrast,up-regulation of Sirt2 does not impact Nkx2.2 expression level.Sirt2 knock-down via RNAi or inhibition of Sirt2 by sirtinol,a Sirt2 activity inhibitor,blocks CG4 cell differentiation.Over-expression of Sirt2 facilitates CG4 cell differentiation at both molecular and cellular levels,enhancing expression of myelin basic protein and facilitating the growth of cell processes.We have conclusively demonstrated that Sirt2 enhances CG4 oligodendroglial differentiation and report a novel mechanism through which Nkx2.2 represses CG4 oligodendroglial differentiation via Sirt2. | Shaoping Ji JRonald Doucette Adil J.Nazarali | 2011 | Journal of Molecular Cell Biology2011，3，6： | 1 |
| 5 | Improved Synthesis of Miriplatin显示文摘Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt(C6H14N2)(I) 2 was synthesized from K 2 PtCl 4 , KI and (1R,2R)-1,2-cyclohexanediamine, Pt(C 6 H 14 N 2 )(I) 2 was reacted with AgNO 3 to prepare Pt(C 6 H 14 N 2 )(H 2 O) 2 (NO 3 ) 2 solution then was subsequently reacted with CH 3 (CH 2 ) 12 COONa in n-butanol to give target compound with satisfied yield 81%(based on Pt(C 6 H 14 N 2 )I 2 ). The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis, the structure was consistent with the target compound. | WANG Qingkun PU Shaoping LIU Zhudong LIU Liangmeng LIAO Yunxing JIN Ji | 2012 | 贵金属2012，33，A01： | 0 |
| 6 | Glutathione-triggered non-template synthesized porous carbon nanospheres serve as low toxicity targeted delivery system for cancer multi-therapy显示文摘Nano material based drug delivery system have received great attention in clinical application due to their high therapeutic efficacy and lower side effects than classical method,multi-functional nanomaterial also have shown the excellent performance at cancer theranostic and durg tracking in vivo and in vitro.However,most of these works are influenced by the bio-toxicity of applied nanomaterials,which could influence the diagnostic results and treatment effect.Therefore,we have prepared a high biocompatibility porous carbon nanospheres(PCNs) based nano-system(PCN-siRNA-DOX-FA) for targeted drug delivery and the ranostic.The surface modifications have increased dispersion and stability of the PCNs,and folic acid(FA) had enhanced the active target ability for FA receptor positive cell lines.Moreover,through the siRNA structure and doxorubicin(DOX) loading,biological and chemical combined multi-therapy was achieved in cancerous cells.This constructed nano-system could positively improve the biotoxicity problem of nanomaterial and provide a potential platform for clinical cancer theranostic applications. | Haoyuan Lv Shuai Ma Zhenbo Wang Xiaoting Ji Shaoping Lv Caifeng Ding | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
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