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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | A high-responsivity high-bandwidth asymmetric twin-waveguide coupled InOaAs-InP-InAlAs avalanche photodiode显示文摘 | JIAN Wei XIA Feng-nian FORREST S R | 2002 | IEEE Photon Technol Lett2002，14，11： | 1 |
| 3 | Structures,thermal stabilities,and magnetic properties of four new lanthanide coordinative frameworks incorporating mixed organic ligands显示文摘 | Jian B R Liu H C Lin Y W Huang S C Hsu K F | | 0，，1： | 1 |
| 4 | Thermal and mechanical characterizations of a Zr-based bulk metallic glass composite tough- ened by in-situ precipitated Tε-rich particles 显示文摘 | JANG J S C JIAN S R PAN D J | 2010 | Intermetallics2010，18，： | 1 |
| 5 | Microbial pretreatment of cotton stalks by submerged cultivation of Phanerochaete chrysosporium 显示文摘 | Shi Jian Sharma-Shivappa Ratna R Chinn M S | 2009 | Bioresource Technology2009，100，19： | 1 |
| 6 | Semivariogram modeling by weighted least squares显示文摘 | Jian X D Olea R A Yu Y S | 1996 | Computers & Geosciences1996，22，4： | 1 |
| 7 | Structur- al and nanomechanical properties of a-plane ZnO thin films deposited under different oxygen partial pres- sures显示文摘 | JIAN S R CHEN H G CHEN G J | 2012 | Curr Appi Phys2012，12，3： | 1 |
| 8 | Berkovich nanoindentation on AlN Thin Films 显示文摘 | JIAN S R CHEN G J LIN T C | 2010 | Nanoscale Research Letters2010，5，6： | 1 |
| 9 | Microbial pretreatment of cotton stalks by solid state cultivation of Phanerochaete chrysosporium显示文摘 | JIAN S CHINN M S SHARMA-SHIVAPPA R R | 2008 | Bioresource Technology2008，99，14： | 1 |
| 10 | Managing the exchange of information in product development显示文摘 | YASSINE A SREENIVAS R S JIAN Zhu | 2008 | Europe -an Journal of Operational Research2008，184，1： | 1 |
| 11 | Determination of trace bisphenol A in complex samples using selective molecularly imprinted solid-phase extraction coupled with capillary electrophoresis显示文摘 | Mei S R Wu D Jian$ M | 2011 | Microchemical Journal2011，98，： | 1 |
| 12 | A new approch to thermochemical calculations of condensed fuel-oxidizer mixtures显示文摘 | Jian S R Adiga K C | 1981 | Combustion and Flame1981，40，1： | 1 |
| 13 | Three--dimensionalspatial distribution of adults of Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) in stored wheat under different temperatures, moisture contents, and adult densities 显示文摘 | Jian F Larson R Jayas D S | 2011 | Journal of Stored Products Research2011，47，2： | 1 |
| 14 | Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery 显示文摘 | Jian D Sun R Zhang S H | 2004 | Macromol Rapid Commun2004，25，2： | 1 |
| 15 | Indentation-induced mechanical deformation behaviors of AlN thin films deposited on c-plane sapphire 显示文摘 | JIAN S R JUANG J Y | 2012 | Journal of Nanomaterials2012，2012，36： | 1 |
| 16 | Mi- crobial pretreatment of cotton stalks by solid state cultiva- tion of Phanerochaete chrysosporium显示文摘 | SHI Jian CHINN M S SHARMA-SHIVAPPA R R | 2008 | Bioresour Techn- ol2008，99，14： | 1 |
| 17 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 18 | Effect of microbial pretreatment on enzymatic hydrolysis and fermentation of cotton stalks fiJr ethanol production 显示文摘 | Shi Jian Ratna R S Mart C el al | 2009 | Biomass and Bioenergy2009，33，4： | 1 |
| 19 | Thesequence and de novo assembly of the giant panda genome显示文摘 | LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J | 2010 | Na-ture2010，463，： | 1 |
| 20 | Nanomechanical properties of AlN(103) thin films by nanoindentation 显示文摘 | JIAN S R CHEN G J JANG J S C | 2010 | Journal of Alloys and Compounds2010，494，12： | 1 |
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