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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Occurrence of conjugated cis-9,trans-11-octadecadienoic acid in bovine milk:effects of feed and dietary regimen显示文摘 | Jing J Joerck BL | 1996 | dairy SCIL1996，79，： | 1 |
| 3 | Weekly contraception with mifepristone 显示文摘 | PEI KY XIAO BL JING XP | 2007 | Contraception2007，75，1： | 1 |
| 4 | Tissue -specific expression profiling of receptor for advanced glycation end products and its soluble forms in esophageal and lung cancer显示文摘 | Jing RR Cui M Sun BL | 2010 | Genet Test Mol Biomark- ers2010，14，3： | 1 |
| 5 | Evaluation of coronary artery bypass graft patency using three-dimensional reconstruction and flow study on electron beam tomography 显示文摘 | LU B DAI RP JING BL | 2000 | J Comput Assist Tomogr2000，24，5： | 1 |
| 6 | STM capacity for Chinese and English Language Materials 显示文摘 | Yu BL Zhang WT Jing QC | 1985 | Memory and Cognition1985，13，3： | 1 |
| 7 | Winter wheat yield estimation based on assimilated Sentinel-2 images with the CERES-Wheat model显示文摘Assimilating Sentinel-2 images with the CERES-Wheat model can improve the precision of winter wheat yield estimates at a regional scale. To verify this method, we applied the ensemble Kalman filter(EnKF) to assimilate the leaf area index(LAI) derived from Sentinel-2 data and simulated by the CERES-Wheat model. From this, we obtained the assimilated daily LAI during the growth stage of winter wheat across three counties located in the southeast of the Loess Plateau in China: Xiangfen, Xinjiang, and Wenxi. We assigned LAI weights at different growth stages by comparing the improved analytic hierarchy method, the entropy method, and the normalized combination weighting method, and constructed a yield estimation model with the measurements to accurately estimate the yield of winter wheat. We found that the changes of assimilated LAI during the growth stage of winter wheat strongly agreed with the simulated LAI. With the correction of the derived LAI from the Sentinel-2 images, the LAI from the green-up stage to the heading–filling stage was enhanced, while the LAI decrease from the milking stage was slowed down, which was more in line with the actual changes of LAI for winter wheat. We also compared the simulated and derived LAI and found the assimilated LAI had reduced the root mean square error(RMSE) by 0.43 and 0.29 m^(2) m^(–2), respectively, based on the measured LAI. The assimilation improved the estimation accuracy of the LAI time series. The highest determination coefficient(R2) was 0.8627 and the lowest RMSE was 472.92 kg ha^(–1) in the regression of the yields estimated by the normalized weighted assimilated LAI method and measurements. The relative error of the estimated yield of winter wheat in the study counties was less than 1%, suggesting that Sentinel-2 data with high spatial-temporal resolution can be assimilated with the CERES-Wheat model to obtain more accurate regional yield estimates. | LIU Zheng-chun WANG Chao Bl Ru-tian ZHU Hong-fen HE Peng JING Yao-dong YANG Wu-de | 2021 | Journal of Integrative Agriculture2021，20，7： | 0 |
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