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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Emerging concepts in liver graft preservation显示文摘The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion(MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures(hypothermia at 4 ℃, normothermia a t 3 7 ℃ and subnormothermia at 20 ℃- 2 5 ℃). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the 'state of the art' and future perspectives in static and dynamic liver graft preservation in order to improve graft viability. | Mohamed Bejaoui Eirini Pantazi Emma Folch-Puy Pedro M Baptista Agustín García-Gil René Adam Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，2： | 5 |
| 3 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 4 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 5 | Chronic pancreatitis显示文摘 | Joan M Braganza Stephen H Lee Rory F McCloy Michael J McMahon | 2011 | The Lancet . 2011 (9772)2011，，： | 2 |
| 6 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 7 | Are island plant communi- ties more invaded than their mainland counterparts显示文摘 | Montserrat V Joan P Ana M | 2010 | Journal of Vegetation Science2010，21，3： | 1 |
| 8 | Chronic pancreatitis显示文摘 | Joan M Braganza Stephen H Lee Rory F McCloy Michael J McMahon | 2011 | The Lancet2011，，9772： | 1 |
| 9 | Acute Hyperglycemia State Is Associated With Lower tPA-Induced Recanalization Rates in Stroke Patients显示文摘 | Carlos M Joan M | 2005 | Stroke2005，36，： | 1 |
| 10 | Microbical contamination of stored hydrocarbon fuels and its control显示文摘 | CHRISTINE C G FATIMA M B JOAN K | 2003 | Journal of Microbiology2003，32，4： | 1 |
| 11 | Compound repetition in oxide-oxide interactions:the system Li2O-V2O5显示文摘 | ARNOLD R JOAN M | 1962 | Journal of Physics and Chemistry1962，66，6： | 1 |
| 12 | Locative inversion in Chiche? a: a case study of factorization in grammar 显示文摘 | Bresnan Joan Kanerva J M | 1989 | Linguistic inquiry1989，，： | 1 |
| 13 | Patient reported donor-site morbidity following anterolateral thigh free flaps 显示文摘 | Joan E Lipa M DM Se | 2005 | J Reconstructive Microsu- rgery2005，21，6： | 1 |
| 14 | A methodological approach of climatological modelling of air temperature and precipitation through GIS techniques 显示文摘 | Miquel Ninyerola Xavier Pons Joan M Roure | 2000 | International Journal of Climatology2000，20，14： | 1 |
| 15 | Comparison of optical bioluminescence reporter gene and superparamagentic iron uxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation显示文摘 | Lan Y Chen Joan M Greve Oliver Gheysens | 2009 | Mol Imaging Biol2009，11，： | 1 |
| 16 | A comparison of hydrogen ,methanol and gasoline as fuels for fuel cell vehicles:implications for vehicles design and infrastructure development 显示文摘 | Joan M Ogden | 1999 | Journal of Power sources1999，79，： | 1 |
| 17 | Vascular endothelial growth fac-tor and basic fibroblast growth factor in exudative age-re-lated macular degeneration and diffuse diabetic macular e-dema显示文摘 | Joans J B Neumaier M | 2007 | Ophthalmic Res2007，39，3： | 1 |
| 18 | A Balance Theory Perspective of Triadic Supply Chain Relationships显示文摘 | Phillips Joan M Ben S Liu Thomas G Costetlo | 1998 | Journal of Marketing Theory and Practice1998，6，： | 1 |
| 19 | Cloning, characterization, and transcription of three lacease genes from Gaeumannomyces graminisvar trltici the take-All fungus显示文摘 | Anastasia P Litvintseva Joan M | 2002 | Appl Envir Microbiol2002，68，3： | 1 |
| 20 | Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius 显示文摘 | RUEY M L GERMAIN G JOAN B | 1999 | Genes & Dev1999，13，6： | 1 |
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