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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Investigation of transformations in a southern California constructed wastewater treatment wetland显示文摘 | James J Sartoris Joan S Thullan Larry B Barber | 2000 | Ecological Engineering2000，，14： | 1 |
| 4 | Interferon activity of mitogen-induced chicken splenic lymphocytcs which do not express interferon mRNA显示文摘 | AGARWAL S K CLOUD S S JOAN B | 1996 | Vet Immunol Immunopathol1996，53，34： | 1 |
| 5 | Decoupled double syn- chronous referecnce frame PLL for power converters con- trol 显示文摘 | Pedro R Josep P Joan B | 2007 | IEEE Transactions on Power Electronics2007，22，2： | 1 |
| 6 | Microbical contamination of stored hydrocarbon fuels and its control显示文摘 | CHRISTINE C G FATIMA M B JOAN K | 2003 | Journal of Microbiology2003，32，4： | 1 |
| 7 | Vascular endothelial growth fac-tor and basic fibroblast growth factor in exudative age-re-lated macular degeneration and diffuse diabetic macular e-dema显示文摘 | Joans J B Neumaier M | 2007 | Ophthalmic Res2007，39，3： | 1 |
| 8 | Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius 显示文摘 | RUEY M L GERMAIN G JOAN B | 1999 | Genes & Dev1999，13，6： | 1 |
| 9 | Classification from microar- ray data using probabilistic discriminant partial least squares with reject option 显示文摘 | Cristina B Joan F Ricard B | 2009 | Talanta2009，80，1： | 1 |
| 10 | Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius显示文摘 | RUEY M L GERMAIN G JOAN B | 1999 | Genes & Dev1999，13，6： | 1 |
| 11 | Separations of some cou- marins of higher plants by liquid chromatography 显示文摘 | Thompson H Joan B Stewart A | 1984 | J Chro-matogr1984，314，： | 1 |
| 12 | Systemic inflammation in chronic obstructive pulmonary disease:a population-based study显示文摘 | Francisco Garcia-Rio Marc Miravitlles Joan B Soriano | 2010 | Respir Res2010，11，1： | 1 |
| 13 | Sustained accumulation of methyl salicylate alters antioxidant protection and reduces tolerance of holm oak to heat stress显示文摘 | JOAN L JISEO P SERGU M B | 2005 | Physiologia Plantarum2005，124，3： | 1 |
| 14 | A practical update on the use ofbortezomib in the management of Multiple Myeloma显示文摘 | Jesus SM Joan B Mario B | 2006 | The Oncolo-gist2006，11，1： | 1 |
| 15 | Paper assets, real debts: An ecological-economic exploration of the global economic crisis显示文摘 | Giorgos K Joan M Richard B | 2009 | Critical Perspective on International Business2009，5，12： | 1 |
| 16 | Synthesis of 5-(sulfamoylmethyl)indole显示文摘 | JOAN B TOMAS R MONTSERRAT A | 2001 | Tetrahedron2001，57，6： | 1 |
| 17 | Cytokine pro- files of peripheral blood mononuclear ceils from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral anti- gens显示文摘 | LAILA D MONICA B JOAN P | 2003 | J Gen Virol2003，，84： | 1 |
| 18 | Assessing land-use and land-cover changes in relation to geographic factors and urban planning in the metropolitan area of ConcepciSn (Chile): implications for biodiversity conservation显示文摘 | CAROLINA R JOAN P CORINA B | 2013 | Applied Geography2013，39，： | 1 |
| 19 | Paper assets,real debts:An ecological-economic exploration of the global economic crisis显示文摘 | GIORGOS K JOAN M RICHARD B | 2009 | Critical Perspective on International Business2009，，12： | 1 |
| 20 | Pattern codification strategies in structured light systems 显示文摘 | JOAQUIM S JORDI P JOAN B | 2004 | Pattern Recognition2004，37，4： | 1 |
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