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| 1 | Intraductal biliary and pancreatic endoscopy: An expanding scope of possibility显示文摘Intraductal endoscopy describes the use of an endoscope to directly visualize the biliary and pancreatic ducts. For many years, technological challenges have made performing these procedures difficult. The 'mother-baby' system and other various miniscopes have been developed, but routine use has been hampered due to complex setup, scope fragility and the time consuming, technically demanding nature of the procedure. Recently, the SpyGlass peroral cholangiopancreatoscopy system has shown early success at providing diagnostic information and therapeutic options. The clinical utility of intraductal endoscopy is broad. It allows better differentiation between benign and malignant processes by allowing direct visualization and targeted sampling of tissue. Therapeutic interventions, such as electrohydraulic lithotripsy (EHL), laser lithotripsy, photodynamic therapy, and argon plasma coagulation (APC), may also be performed as part of intraductal endoscopy. Intraductal endoscopy significantly increases the diagnostic and therapeutic yield of standard endoscopic retrograde cholangiography (ERCP), and as technology progresses, it is likely that its utilization will only increase. In this review of intraductal endoscopy, we describe in detail the various endoscopic platforms and their diagnostic and clinical applications. | Joel R Judah Peter V Draganov | 2008 | World Journal of Gastroenterology2008，14，20： | 12 |
| 2 | Endoscopic therapy of benign biliary strictures显示文摘Benign biliary strictures are being increasingly treated with endoscopic techniques. The benign nature of the stricture should be first confirmed in order to ensure appropriate therapy. Surgery has been the traditional treatment, but there is increasing desire for minimally invasive endoscopic therapy. At present, endoscopy has become the first line approach for the therapy of post- liver transplant anastomotic strictures and distal (Bismuth Ⅰand Ⅱ) post-operative strictures. Strictures related to chronic pancreatitis have proven more difficult to treat, and endoscopic therapy is reserved for patients who are not surgical candidates. The preferred endoscopic approach is aggressive treatment with gradual dilation of the stricture and insertion of multiple plastic stents. The use of uncovered self expandable metal stents should be discouraged due to poor long-term results. Treatment with covered metal stents or bioabsorbable stents warrants further evaluation. This area of therapeutic endoscopy provides an ongoing opportunity for fresh research and innovation. | Joel R Judah Peter V Draganov | 2007 | World Journal of Gastroenterology2007，13，26： | 11 |
| 3 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 4 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 5 | New concept to remove heavy metals from liquid waste based on electrochemical pH-switehable immobilized ligands 显示文摘 | Pascal V Laetitia D Joel L | 2007 | Applied Surface Science2007，253，6： | 1 |
| 6 | Organizational niches and the dynamics of organizational mortality显示文摘 | Baum Joel A C Singhn Jitendra V | 1994 | The American Journal of Sociology1994，，2： | 1 |
| 7 | Colonography: current status, research directions and challenges 显示文摘 | Joel G F Thomas J V | 2002 | Eur Radiol2002，12，： | 1 |
| 8 | The prevention of ovarian hyperstimulation syndrome显示文摘 | Mathur R S Joels L A Akande A V | 1996 | Br J Obstet Gynaecol1996，103，8： | 1 |
| 9 | 2D-QSAR, 3D-QSAR and molecular docking of 4(1H)-quinolones analogues with antimalarial activities显示文摘 | THULIE P J V RICARDO G I JOEL J M A | 2013 | J Mol Graph Model2013，46，： | 1 |
| 10 | Composite pseudolink end-point control of flexible manipulators 显示文摘 | King Joel O Gourishankar V G Rink Raymond E | 1990 | IEEE Transactions on Systems Man and Cybernetics1990，20，5： | 1 |
| 11 | Etude spectroscopique (IR,RMN1H,masse) comparée des acides indolyl-1 acétique (AIA-1) indolyl-2 acétique (AIA-2) et indolyl-3 acétique (AIA-3) et de leurs esters méthyliques (masse)显示文摘 | Joel V Bernard L | 1983 | Spectrochim Acta A1983，39，10： | 1 |
| 12 | Overview of US incubators and the case of the Austin Technology Incubator 显示文摘 | JOEL WIGGINS DAVID V GIBSON | 2003 | Intematlonal Journal of Entrepreneurship and Innovation Management2003，3，1： | 1 |
| 13 | Fabrication and modeling of uniform-waist single-mode tapered optical fiber sensors 显示文摘 | JOEL V DAVID M H EFRAIN M | 2003 | Applied Optics2003，42，13： | 1 |
| 14 | On the use of optical fiber sensors (CCGs and PCFI) for harsh environments显示文摘 | David B Vittoria F Joel V | 2010 | Waves2010，1889，8297： | 1 |
| 15 | Dimensional changes of starch microcellular foam during the exchange of water with ethanol and subsequenl drying显示文摘 | Sameerkumar V P Richard A V Joel J P | 2010 | Biosources2010，5，1： | 1 |
| 16 | Associations between Recent Exposure to Ambient Fine Particulate Matter and Blood Pressure in the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Auchincloss Amy H Roux Ana V Diez Dvonch J Timothy Brown Patrick L Barr R Graham Daviglus Martha L Goff David C Kaufman Joel D O’Neill Marie S | 2008 | Environmental Health Perspectives2008，，4： | 1 |
| 17 | Colonography:curtent status,research directions and challenges显示文摘 | Joel G F Thomas J V | 2002 | Eur Radial2002，12，： | 1 |
| 18 | Holmium:YAG laser cystolithotripsy of large Bladder calculi显示文摘 | Joel M H Teichrran Rogenes V J Bradley J | 1997 | Urology1997，50，1： | 1 |
| 19 | Access to catheterisation facilities in patients admitted with acute coronary syndrome:multinational registry study显示文摘 | FRANS V de W JOEL M G ALVARO A | 2005 | BMJ2005，330，7489： | 1 |
| 20 | Organizational Niches and the Dynamics of Organizational Founding 显示文摘 | Joel Baum A C Singh J V | 1994 | Organization Science1994，5，4： | 1 |
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