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| 1 | Mechanical and cellular processes driving cervical myelopathy显示文摘Cervical myelopathy is a well-described clinical syndrome that may evolve from a combination of etiological mechanisms. It is traditionally classified by cervical spinal cord and/or nerve root compression which varies in severity and number of levels involved. The vast array of clinical manifestations of cervical myelopathy cannot fully be explained by the simple concept that a narrowed spinal canal causes compression of the cord, local tissue ischemia, injury and neurological impairment. Despite advances in surgical technology and treatment innovations, there are limited neuro-protective treatments for cervical myelopathy, which reflects an incomplete understanding of the pathophysiological processes involved in this disease. The aim of this review is to provide a comprehensive overview of the key pathophysiological processes at play in the development of cervical myelopathy. | Roisin T Dolan Joseph S Butler John M O'Byrne Ashley R Poynton | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 2 | 早产治疗的临床证据显示文摘截止至2002年5月,现有早产治疗的临床证据如下: (1) 高危早产:在一些国家实施的RCT发现,在降低早产危险方面,加强产前保健与普通产前保健没有明显差异.包括5个RCT的1个系统评价发现,对有宫颈改变的妇女行宫颈环扎术有不同的结果,没有明确的结论.1个大样本的RCT发现,孕9~29周宫颈功能可能不全的妇女进行预防性宫颈环扎手术与不环扎相比,能明显降低早产(<33孕周),但也会明显增加产褥感染的危险.另外4篇较小样本的RCT发现,孕10~30周、具各种早产高危因素的妇女,进行预防性宫颈环扎手术与不环扎相比,并不能降低早产(<34孕周).1篇系统评价的2个RCT报告,对有宫颈改变的妇女进行环扎术有不同的结果,其中1个RCT发现其并不能明显降低早产(<34孕周),而另外1个较小样本的RCT却发现宫颈环扎手术加卧床休息与单纯卧床休息比较,能明显降低34周前的早产.没有1个RCT证实行环扎术加卧床休息与单纯卧床休息相比,能降低围生儿死亡率. (2) 胎膜早破:1个系统评价发现,对胎膜早破的妇女,抗生素较安慰剂能明显延长孕周、降低新生儿发病率的危险,如新生儿感染、出生后氧疗、脑部超声异常等.阿莫西林加克拉维酸治疗与新生儿坏死性小肠结肠炎的发生率明显增加有关.一个基于1个RCT的系统评价发现,没有充足的证据证实羊膜腔灌注与不灌注比较能改善胎膜早破后的新生儿结局. (3) 先兆早产的治疗:①β-肾上腺素兴奋剂:1个系统评价发现,β-肾上腺素兴奋剂与安慰剂或不治疗相比,并不能明显降低围生儿死亡率、呼吸窘迫综合征及低体重儿(<2 500 g)发生率,且与与安慰剂或不治疗相比,β-肾上腺素兴奋剂增加孕母副反应,如胸痛、心悸、呼吸困难、震颤、恶心、呕吐、头痛、高血糖、低钾血症.②钙离子通道拮抗剂: 没有关于钙离子通道拮抗剂与安慰剂比较的系统评价或RCT.1个系统评价发现,钙离子通道抑制剂与其它保胎药(主要是β-肾上腺受体兴奋剂)比较,能显著降低48 h内的早产分娩,减少因孕母副反应退出治疗和新生儿发病率.③硫酸镁:1个系统评价发现,硫酸镁与安慰剂比较,并不能明显降低孕36周前的早产率、围生儿死亡率、呼吸窘迫综合征的发生率.另一个系统评价发现,硫酸镁和其他宫缩抑制剂(β-肾上腺素兴奋剂、钙离子通道拮抗剂、前列腺素合成抑制剂、硝化甘油、酒精和葡萄糖注射剂)比较,并不能明显降低48 h内早产率(尽管结果没有差异).④垂体受体拮抗剂(阿托西班):1个系统评价纳入 2个RCT,对阿托西班和安慰剂治疗早产进行比较有不同的结果.较大样本的RCT发现,阿托西班较安慰剂能延长孕周,但阿托西班增加了孕28周以下的胎儿死亡率.另一个RCT发现,阿托西班增加了48 h内的早产.⑤前列腺素抑制剂(消炎痛):1个系统评价发现,消炎痛与安慰剂比较,能明显降低孕37周前的48 h和7天的早产率的证据有限.然而,同时发现消炎痛与安慰剂或不治疗相比,并不能明显降低围生儿死亡率、新生儿呼吸窘迫综合征、肺支气管发育不良、坏死性小肠结肠炎、新生儿败血症或低体重儿.但这个系统评价样本太小,尚不能发现有临床意义的差异. (4) 择期或非择期剖宫产对早产妇女治疗效果:1个系统评价结果发现,择期剖宫产较非择期剖宫产会增加孕母的发病率,却不能降低新生儿的发病率和死亡率.但尚不能证明此效果是否对新生儿有临床意义. (5) 改善早产妊娠结局的干预措施:①对早产者采用皮质类固醇:1个系统评价认为,对可能发生早产的妇女使用皮质激素较安慰剂或不处理能明显降低早产儿出生后呼吸窘迫综合征、新生儿死亡率和颅内出血的发生.②促甲状腺激素释放激素在早产中的运用:1个系统评价发现,在早产的高危妇女中,促甲状腺激素释放激素和类固醇激素联合应用与单用皮质类固醇激素比较,对新生儿结局的影响无明显差异,但会明显增加孕母和胎儿的不良反应.③抗生素:1个系统评价发现,抗生素与安慰剂比较,不能延长孕周、降低新生儿死亡率,但可降低孕母感染率. | Bridgette Byrne John Morrison 李蓉 | 2005 | 中国循证医学杂志2005，5，3： | 4 |
| 3 | Three-dimensional imaging improves surgical performance for both novice and experienced operators using the da Vinci Robot System显示文摘 | John C. Byrn Stefanie Schluender Celia M. Divino John Conrad Brooke Gurland Edward Shlasko Amir Szold | 2007 | The American Journal of Surgery2007，，4： | 3 |
| 4 | Exercise interventions for older adults: A systematic review of meta-analyses显示文摘Background:The evidence concerning which physical exercise characteristics are most effective for older adults is fragmented.We aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of metaanalyses of exercise interventions in older adults.Methods:We searched the Cochrane Database of Systematic Reviews,PsycInfo,MEDLINE,Embase,CINAHL,AMED,SPORTDiscus,and Web of Science for articles that met the following criteria:(1)meta-analyses that synthesized measures of improvement(e.g.,effect sizes)on any outcome identified in studies of exercise interventions;(2)participants in the studies meta-analyzed were adults aged 65+or had a mean age of 70+;(3)meta-analyses that included studies of any type of exercise,including its duration,frequency,intensity,and mode of delivery;(4)interventions that included multiple components(e.g.,exercise and cognitive stimulation),with effect sizes that were computed separately for the exercise component;and(5)meta-analyses that were published in any year or language.The characteristics of the reviews,of the interventions,and of the parameters improved through exercise were reported through narrative synthesis.Identification of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the reviews.The study included 56 meta-analyses that were heterogeneous in relation to population,sample size,settings,outcomes,and intervention characteristics.Results:The largest effect sizes for improvement were found for resistance training,meditative movement interventions,and exercise-based active videogames.Conclusion:The review identified important gaps in research,including a lack of studies investigating the benefits of group interventions,the characteristics of professionals delivering the interventions associated with better outcomes,and the impact of motivational strategies and of significant others(e.g.,carers)on intervention delivery and outcomes. | Claudio Di Lorito Annabelle Long Adrian Byrne Rowan H.Harwood John R.F.Gladman Stefan Schneider Pip Logan Alessandro Bosco Veronika van der Wardt | 2021 | Journal of Sport and Health Science2021，10，1： | 3 |
| 5 | Complete remission of unresectable hepatocellular carcinoma treated with reduced dose of sorafenib: a case report显示文摘 | Sean Xiang Wang Abigail Byrnes Sadhna Verma John R. Pancoast Olivier Rixe | 2010 | Targeted Oncology2010，，1： | 2 |
| 6 | Mechanisms of plasma non‐transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients显示文摘 | John B. Porter Patrick B. Walter Lynne D. Neumayr Patricia Evans Sukhvinder Bansal Maciej Garbowski Marcela G. Weyhmiller Paul R. Harmatz John C. Wood Jeffery L. Miller Colleen Byrnes Guenter Weiss Markus Seifert Regine Grosse Dagmar Grabowski Angelica Sc | 2014 | Br J Haematol2014，，5： | 1 |
| 7 | Experimental measurement of boron isotope fractionation in seawater显示文摘 | Kateryna Klochko Alan J. Kaufman Wengsheng Yao Robert H. Byrne John A. Tossell | 2006 | Earth and Planetary Science Letters2006，，1： | 1 |
| 8 | 显示文摘 | Mukhtar H Ahmed Tia E Keyes John A Byrne | 2011 | Journal of Photochemistry and Photobiology A: Chemistry2011，222，： | 1 |
| 9 | How to Rally Corporate Governance显示文摘 | John A Byrne | 2002 | Business Week2002，，6： | 1 |
| 10 | DOSE A URETERAL ACCESS SHEATH FACILITATE URETEROSCOPY?显示文摘 | JOHN KOURAMBAS ROBERT R. BYRNE GLENN M. PREMINGER | 2001 | The Journal of Urology2001，，： | 1 |
| 11 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 12 | Late Outcomes for Aortic Valve Replacement With the Carpentier-Edwards Pericardial Bioprosthesis: Up to 17-Year Follow-Up in 1,000 Patients显示文摘 | R. Scott McClure Narendren Narayanasamy Esther Wiegerinck Stuart Lipsitz Ann Maloney John G. Byrne Sary F. Aranki Gregory S. Couper Lawrence H. Cohn | 2010 | The Annals of Thoracic Surgery2010，，5： | 1 |
| 13 | Knowledge networks in new product development projects:a transactive memory perspective显示文摘 | AL I E AKGUN JOHN BYRNE HAL IT KESKIN GARY S LYNN SAL IH Z IMAMOGLU | | 0，，： | 1 |
| 14 | Mitral Valve Surgery in Advanced Heart Failure显示文摘 | Thomas G. Di Salvo Michael A. Acker G. William Dec John G. Byrne | 2010 | Journal of the American College of Cardiology2010，，4： | 1 |
| 15 | Knowledge networks in new product development projects:a transactive memory perspective显示文摘 | ALI E JOHN BYRNE | 2005 | Information & Management2005，，42： | 1 |
| 16 | Synergistic action of a triple peptide complex on an essential extra‐cellular matrix protein exhibits significant anti‐aging benefits显示文摘 | Adam John Byrne Tamara Al‐Bader | 2010 | journal of cosmetic dermatology2010，9，2： | 1 |
| 17 | American policy conflict in the greenhouse: Divergent trends in federal, regional, state, and local green energy and climate change policy显示文摘 | John Byrne Kristen Hughes Wilson Rickerson Lado Kurdgelashvili | 2007 | Energy Policy2007，，9： | 1 |
| 18 | Three-dimensional imaging improves surgical performance for both novice and experienced operators using the da Vinci Robot System显示文摘 | John C. Byrn Stefanie Schluender Celia M. Divino John Conrad Brooke Gurland Edward Shlasko Amir Szold | 2007 | The American Journal of Surgery2007，，4： | 1 |
| 19 | An initial experience with 85 consecutive robotic-assisted rectal dissections: improved operating times and lower costs with experience显示文摘 | John C. Byrn Jennifer E. Hrabe Mary E. Charlton | 2014 | Surgical Endoscopy2014，，： | 1 |
| 20 | The virtual corporation显示文摘 | JOHN A BYRNE | 1993 | Business Week1993，，8： | 1 |
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