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| 1 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 3 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Safe upper limits for oxygen enrichment of room air at high altitude显示文摘 | West J B | 2001 | High Alt Med Biol2001，2，1： | 1 |
| 5 | Carbonyl sulfide hydrolysis using alumina catalyst显示文摘 | WILLIAMS B Peter YOUNG Nicola C JOHN West | 1999 | Catalysis Today1999，49，： | 1 |
| 6 | The Novel Marker, DOG1 , Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status显示文摘 | Robert B. West Christopher L. Corless Xin Chen Brian P. Rubin Subbaya Subramanian Kelli Montgomery Shirley Zhu Catherine A. Ball Torsten O. Nielsen Rajiv Patel John R. Goldblum Patrick O. Brown Michael C. Heinrich Matt van de Rijn | 2004 | The American Journal of Pathology2004，，1： | 1 |
| 7 | A new unusual low molecular weight carbohydrate in the red algal genus Hypoglossum (Delesseriaceae, Ceramiales) and its possible function as an osmolyte显示文摘 | Ulf Karsten Dirk Michalik Manfred Michalik John A. West | 2005 | Planta2005，，2： | 1 |
| 8 | Predicting Acute Mountain Sickness 显示文摘 | John B West | 2014 | High Alt Med Biol2014，15，4： | 1 |
| 9 | Hydroquinone Is Not A Phagostimulant For The Formosan Subterranean Termite显示文摘 | Ashok K. Raina John M. Bland Weste Osbrink | 2005 | Journal of Chemical Ecology2005，，3： | 1 |
| 10 | low temperature hydrolysis of carbonyl sulfide using γ-alumina catalysts显示文摘 | JOHN West WILLIAMS B P Young Nicola C | 2001 | Catalysis Letters2001，74，34： | 1 |
| 11 | Association of Contemporary Sensitive Troponin I Levels at Baseline and Change at 1 Year With Long-Term Coronary Events Following Myocardial Infarction or Unstable Angina显示文摘 | Harvey D. White Andrew Tonkin John Simes Ralph Stewart Kristy Mann Peter Thompson David Colquhoun Malcolm West Paul Nestel David Sullivan Anthony C. Keech David Hunt Stefan Blankenberg | 2014 | Journal of the American College of Cardiology2014，，4： | 1 |
| 12 | Effect of Pravastatin on Rate of Kidney Function Loss in People With or at Risk for Coronary Disease显示文摘 | Marcello Tonelli Chris Isles Timothy Craven Andrew Tonkin Marc A. Pfeffer James Shepherd Frank M. Sacks Curt Furberg Stuart M. Cobbe John Simes Malcolm West Chris Packard Gary C. Curhan | 2005 | Circulation2005，，2： | 1 |
| 13 | The low-temperature hydrolysis of carbonyl sulfide and carbon disulfide:a review 显示文摘 | COLIN Rhodes STEWART A Riddel JOHN West | 2000 | J Catal2000，59，： | 1 |
| 14 | The low-temperature hydrolysis of carbonyl sulfide and carbon disulfide: a review 显示文摘 | Colin Rhodes Stewart A Riddel John West | 2000 | Catalysis Today2000，59，： | 1 |
| 15 | Arabidopsis LEAFY COTYLEDON1 Is Sufficient to Induce Embryo Development in Vegetative Cells显示文摘 | Tamar Lotan Masa-aki Ohto Kelly Matsudaira Yee Marilyn A.L West Russell Lo Raymond W Kwong Kazutoshi Yamagishi Robert L Fischer Robert B Goldberg John J Harada | 1998 | Cell1998，，7： | 1 |
| 16 | Structural Contingency Theory and Individual Differences: Examination of External and Internal Person-Team Fit显示文摘 | Hollenbeck John R West | 2002 | Journal of Applied Psychology2002，87，3： | 1 |
| 17 | Hydrogen induced ductility losses in austenitic stainless steel welds显示文摘 | John A. Brooks Anton J. West | 1981 | Metallurgical Transactions A1981，，2： | 1 |
| 18 | The Anatomic Pattern of Biliary Atresia Identified at Time of Kasai Hepatoportoenterostomy and Early Postoperative Clearance of Jaundice Are Significant Predictors of Transplant-Free Survival显示文摘 | Riccardo Superina John C. Magee Mary L. Brandt Patrick J. Healey Greg Tiao Fred Ryckman Frederick M. Karrer Kishore Iyer Annie Fecteau Karen West R. Cartland Burns Alan Flake Hanmin Lee Jeff A. Lowell Pat Dillon Paul Colombani Richard Ricketts Yun Li Jeff | 2011 | Annals of Surgery2011，，4： | 1 |
| 19 | Safe upper limits for oxygen enrichment of room air at high altitude显示文摘 | West J B | 2001 | High Altit Med Biol2001，2，1： | 1 |
| 20 | Diver less subsea flange connection显示文摘 | West Alan Giles John Gibson David | 1999 | JournalofOffshoreTechnology1999，7，1： | 1 |
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