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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Effect of stress state on the stress-induced martensitic transformation in polycrystalline Ni-Ti alloy显示文摘 | Jacobus K Sehitoglu H Balzer M | 1996 | Metall Trans1996，27，10： | 1 |
| 3 | Antimicrobial substance from a human Lactobacillus strain显示文摘 | SILVA M JACOBUS N V DENEKE C | 1987 | Antimicrob Agents Chemother1987，31，8： | 1 |
| 4 | Uri- nary Kidney biomarkers for early detection of nephrotoxicity in clinical drug development 显示文摘 | LEONINE VAN MEER MATTHIJS M JACOBUS B | 2013 | Brit J Clin Pharm2013，77，6： | 1 |
| 5 | Sliding Transformers for Linear Contactless Power Delivery显示文摘 | Jacobus M Barnard Jan A Ferreira Jacobus Daniel van WyK | 1997 | IEEE Transactions on Industrial Electronics1997，44，： | 1 |
| 6 | To wards a comprehensive barcode library for arctic life - Ephemeroptera, Plecoptera, and Trichoptera of Churchill, Manitoba, Canada显示文摘 | Zhou X Adamowicz S J Jacobus L M | 2009 | Frontiers in Zoolo- gy2009，，： | 1 |
| 7 | Sliding Transformers for linear contactless power delivery 显示文摘 | Jacobus M B | 1997 | IEEE Trans on Industrial Electronics1997，44，6： | 1 |
| 8 | Kinet-ics of ilmenite dissolution in hydrochloric acid 显示文摘 | Jacobus P van Dyk Nanne M Vegter PC Pistorius | 2002 | Hydro-metallurgy2002，65，： | 1 |
| 9 | In vitro activity of cefoperazone-sulbactam against bacteroides species 显示文摘 | Dias M B S Jacobus N V Tally F P | 1986 | J Antimicrob Chemother1986，18，4： | 1 |
| 10 | Antimicrobial substance from a human Lactobacillus strain显示文摘 | SILVA M JACOBUS N V DENEKE C | | 0，，08： | 1 |
| 11 | Comparison of diesel engine performance and emissions from heat and transesterified vegetable oils显示文摘 | Geyer S Jacobus M Letz S | 1984 | Trans ASAE1984，27，2： | 1 |
| 12 | 18F-2-flu ro-2-de ox y-D glucose positron emission tomographv in staging oflocally advanced breast cancer显示文摘 | Jacobus J M VanderH Nanda C K | 2004 | J Clin Oncol2004，22，7： | 1 |
| 13 | MAP kinase pathways in the yeast Saccharomyces cerevisiae 显示文摘 | Gustin M C Jacobus A Alexander M | 1998 | Microbiology and Molecular Biology Reviews1998，62，4： | 1 |
| 14 | The role of the MAP-Kinase superfamily in β-amyloid toxicity 显示文摘 | Jacobus H | 2001 | Metabolic brain disease2001，16，34： | 1 |
| 15 | Kinetics of ilmenite dissolution in hydrochloric acid 显示文摘 | Jacobus P van Dyk Nanne M Vegter P Chris Pistorius | 2002 | Hydrometallurgy2002，65，： | 1 |
| 16 | Lenalidomiide plus highdose dex- amethasone versus lenalidomiide plus low - dose dexamethasone as initial therapy for newly diagnosed multiple myeloma:au openlabel randomized controlled trial显示文摘 | Rajkumar SV Jacobus S Callander NS Fonseca R Vesole DH Williams ME Abonour R Siegel DS Katz M Greipp PR Eastern Cooperative Oneology Group | 2010 | Lancet Oncol2010，11，1： | 1 |
| 17 | Monoamine Oxidase Inhibition by C4-Substituted Phthalonitriles显示文摘 | Clarina I M Jacobus J B Jacobus P P | 2012 | Bioorganic Chemistry2012，40，1： | 1 |
| 18 | Dissolved organic matter, aluminium and iron interactions:precipitation induced by metalycarbon ratio, pH and competition显示文摘 | KLAAS G J N BORIS J JACOBUS M V | 2002 | The Science of the Total Environment2002，300，： | 1 |
| 19 | Effect of broadspectrum pa- renteral antibiotics on composition of intestinal microflora of hunmns 显示文摘 | Giuliano M Barza M Jacobus NV | 1987 | Antimicrob Agents Chemother1987，31，2： | 1 |
| 20 | Antimicrobial substance from a human Lactobacillus strain Antimicrob显示文摘 | Silva M Jacobus N V Deneke C | 1987 | Agents Chemother1987，31，： | 1 |
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