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| 1 | 乳腺癌组织中TP和TS及DPD mRNA表达与预后的关系显示文摘目的 探讨乳腺癌组织中胸苷酸化酶 (TP)、胸苷酸合成酶 (TS)和二氢嘧啶脱氢酶(DPD)mRNA表达水平及其与预后的关系。方法 采用real time定量PCR技术检测经过微选的 9例正常乳腺组织和 86例乳腺癌组织TP、TS和DPD的mRNA表达水平。结果 肿瘤组织中TP、TS和DPDmRNA表达水平中位数分别为 16 .5 4 ,0 .38和 2 .74 ,正常乳腺组织分别为 11.75 ,0 .2 5和 8.33,差异均无显著性 (P >0 .0 5 )。除年龄与DPD表达呈负相关外 ,TP、TS和DPDmRNA表达与肿瘤体积、淋巴结转移、组织学分级、临床分期均无相关性。TP、DPD高表达组和低表达组之间 ,无瘤生存期和总生存期差异均无显著性。TS高表达组和低表达组无瘤生存期差异无显著性 (P =0 .0 6 9) ;平均总生存期分别为 5 9.0 0和 70 .30个月 ,差异有显著性 (P =0 .0 4 96 )。结论 仅检测TSmRNA对判断乳腺癌预后有参考价值 ,同时检测TP、TS和DPD具有更好的预测价值。 | 李惠翔 Suo ZH 张云汉 Bjrn Risberg Mats G Karlsson Jahn M Nesland | 2004 | 中华肿瘤杂志2004，26，11： | 9 |
| 2 | Geochemistry and isotope data on an ultrahigh-pressure jadeite quartzite from Shuanghe,Dabie Mountains,Eastern China显示文摘 | Liou J G Zhang R Y Jahn B M | 1997 | Lithos1997，41，： | 1 |
| 3 | Petrologic and geochemical constraints on the petrogenesis of Permian - Triassic Emeishan flood basahs in southern China 显示文摘 | Xu Y Chung S Jahn B and Wu G | 2001 | Lithos2001，58，： | 1 |
| 4 | Graph kernels for chemical compounds using topological and three dimensional local atom pair environments显示文摘 | Hinselmann G Fechner N Jahn A | 2010 | Neurocomputing2010，74，1： | 1 |
| 5 | Proliferative activity of leukemic blasts and cytosine arabinoside pharmacedynamics are associated with cytogenetically defined prognostic subgroups in acute mydoid leukemia显示文摘 | Braess J Jahns Streubel G Schoch C | 2001 | Br J Haemtol2001，113，4： | 1 |
| 6 | Discrete pulse modulation strategies for high-frequency inverter systems显示文摘 | Venkataramanan G Divan D M Jahns T M | 1993 | IEEE Transactions on Power Electronics1993，8，3： | 1 |
| 7 | Synthese eines biologischaktiven analogons des prostaglandins E2 ( racemat und reineenantiomere) 显示文摘 | Bartmann W Beck G Jahne G | 1987 | Liebigs Ann Chem1987，1987，4： | 1 |
| 8 | Cytomegalovirus transmission to preterm infants during lactation显示文摘 | Hamprecht K Maschmann J Jahn G | 2008 | J Clin Virol2008，41，3： | 1 |
| 9 | The impact of NOx,CO and VOC emissions on the air quality of Zurich airport显示文摘 | Schürmann G Sch(a)fer A K Jahn C | | 0，，01： | 1 |
| 10 | Is Isoflurane-induced preconditioning dose related显示文摘 | Kehl F Jahn G Mraovic B | 2002 | Anesthesiology2002，96，： | 1 |
| 11 | 20th and 21st century science: Reflections and projections显示文摘 | Jahn R G | 2001 | Journal of Scientific Exploration2001，15，1： | 1 |
| 12 | Solving High noise levels from Roots blowers显示文摘 | Jahn R G M | 1996 | South African Mechanical Engineer1996，46，4： | 1 |
| 13 | Generation and characterization of a GCV resistant HCMV UL97-mutation and a drug sensitive UL54-mutation显示文摘 | Fischer L Laib Sampaio K Jahn G | 2013 | Antiviral Res2013，100，3： | 1 |
| 14 | The impact of NOx, CO and VOC emissions on the air quality of Zurich airport显示文摘 | Schürmann G Sch?fer K Jahn C | 2007 | Atmospheric Environment2007，41，1： | 1 |
| 15 | Binding of 14-3-3 protein to the plasma membrane H1- ATPase AHA2 involves the three C-terminal residues Tyr946-Thr-Val and requires phosphorylation of Thr947 显示文摘 | Fuglsang A Visoonti S Drumm K Jahn T Stensballe A Mattei B Jensen O N Aducci P Palmgren M G | 1999 | Biol Chem1999，274，36： | 1 |
| 16 | Triassic arc magmatism in the Qiangtang area, northern Tibet = Zircon U Pb ages, geochemi- cal and Sr-Nd Hf isotopic characteristics, and tectonic implica- tions显示文摘 | Zhai Q G Jahn B M Su g | 2012 | Journal of Asian Earth Sciences2012，63，： | 1 |
| 17 | Elemental and Sr-Nd iso- tope geochemistry of microgranular enclaves form peralkaline A-type granitic plutons of Eeeishan large igneous province, SW China显示文摘 | Shellnutt J G Jahn B M Dostal J | 2010 | Lithos2010，119，1： | 1 |
| 18 | Establishment of a highly efficient regeneration system from leaf base segrnents of oat (Arena sativa L)显示文摘 | GLESS C LORZ H JAHNE G | 1998 | Plant Cell Reports1998，17，： | 1 |
| 19 | Human cytomegalovirus cell tropism and pathogenesis显示文摘 | Sinzger C Jahn G | 1996 | Intervirology1996，39，56： | 1 |
| 20 | Depleted-mantle source for the Ulungur River A-type granites from North Xinjiang, China geochemistry and Nd-Sr isotopic evidence, and implications for Phanerozoic crustal growth显示文摘 | Han B F Wang S G Jahn B M | 1997 | Chem Geol1997，138，： | 1 |
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