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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 3 | Diffraction of elastic P waves by two equal co-axial circular rigid strips显示文摘 | Verma S K Jain D L | 1992 | European Journal of Mechanics A/Solids1992，11，2： | 2 |
| 4 | Guidelines for endoscopy in pregnant and lactating women显示文摘 | Amandeep K. Shergill Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel Chathadi G. Anton Decker John A. Evans Dana S. Early Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jennifer L | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 5 | Analysis of resin-transfer-molded singlelap joints 显示文摘 | JAIN L K MAI Y W | 1999 | Composites Sciences and Technology1999，59，： | 1 |
| 6 | Hospitalized patients with 2009 H1N1 influenza in the United States, April- June 2009 显示文摘 | Jain S Kamimoto L Bramley AM | 2009 | N Engl J Med2009，361，20： | 1 |
| 7 | Muhidrug resistant acinetobacter in fections: an emerg ng challenge to clinicians显示文摘 | Jain R Danziger L H | 2004 | Ann Pharm acother2004，38，9： | 1 |
| 8 | Novel swine-origin influenza A (H1N1) virus invesrigation team:emergence of a novel swine-origin influenza A(H1N1) virus in humans显示文摘 | Dawood FS Jain S Finelli L | 2009 | N Engl J Med2009，360，25： | 1 |
| 9 | Too Little,Too Early: Introduction Timing and New Product Performance in the Personal Digital Assistant Industry显示文摘 | BAYUS B L JAIN S RAO A G | 1997 | Journal of Marketing Research1997，34，2： | 1 |
| 10 | On-line fingerprint verification 显示文摘 | Jain A K Hong L Bolle R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，4： | 1 |
| 11 | Characterization and identification of forming features for 3-D sheet metal components显示文摘 | Jagirdar R Jain V K Batra J L | 2001 | International Journal of Machine Tools and Manufacture2001，41，9： | 1 |
| 12 | Active versus passive mechanisms in metastasis: do cancer eells crawl into vessels, or are they pushed? 显示文摘 | BOCKHORN M JAIN R K MUNN L L | 2007 | Laneet Oncol2007，8，5： | 1 |
| 13 | Hospitalized patients with 2009 H1N1 influenza in the United States,April-June 2009显示文摘 | Jain S Kamimoto L Brarnley AM | | 0，，20： | 1 |
| 14 | Metabolic engineering of an alternative pathway for ascorbic acid biosynthesis in plants显示文摘 | Jain A K Nessler C L | 2000 | Molecular Breeding2000，6，： | 1 |
| 15 | Modified iterative methods for consistent linear system显示文摘 | GUNAWARDENA A D JAIN S K SNYDER L | 1991 | Linear Algebra and Its Applications1991，154，1： | 1 |
| 16 | Emergence of a novel swine-origin influenza A (HINI) virus in humans显示文摘 | Dawood FS Jain S Finelli L | 2009 | N Engl J Med2009，360，25： | 1 |
| 17 | Hospitalized patients with 2009 H1N1 influenza in the United States,April-June 2009显示文摘 | Jain S Kamimoto L Bramley AM | 2009 | N Engl J Med2009，361，20： | 1 |
| 18 | Physiology of fetal lung fluid clearance and the effect of labor显示文摘 | Jain L Eaton D C | 2006 | Semin Perinatol2006，30，1： | 1 |
| 19 | Hospitalized patients with 2009 H1N1 influenza in the United States显示文摘 | Jain S Kamimoto L Bramley AM | 2009 | N Engt J Med2009，361，20： | 1 |
| 20 | Physiology of fetal lung fluid clearance and the effect oflabor显示文摘 | Jain L Eaton DC | 2006 | SeminPerinatol2006，30，1： | 1 |
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