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| 1 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 2 | EBUS-TBNA在肺部疾病(包括肺癌分期)中的作用综述显示文摘本综述重点阐述EBUS-TBNA在日常肺部疾病诊疗中的作用。所列举的病例为EBUS-TBNA的常见适应征,包括:①肺癌分期;②确诊胸部恶性淋巴结;③诊断中央型肺部肿块;④诊断肺结节病;⑤诊断炎性/良性胸部淋巴结。这项技术应用广泛,有经验的支气管镜医师经过适当的训练后,该技术将成为支气管镜检查的一部分。 | David FIELDING Farzad BASHIRZADEH Phan NGUYEN Alan HODGSON Daniel JAMES 吴齐 吴楠 | 2010 | 中国肺癌杂志2010，，5： | 2 |
| 3 | By-products formation during degradation of isoproturon in aqueous solution. II: chlorination显示文摘 | Giuseppe Mascolo Antonio Lopez Huw James Mike Fielding | 2001 | Water Research2001，，7： | 1 |
| 4 | Nitrate and nitrite inhibition of methanogenesis during denitrification in granular biofilms and digested domestic sludges显示文摘 | Qais Banihani Reyes Sierra-Alvarez James A. Field | 2009 | Biodegradation2009，，6： | 1 |
| 5 | Determination of csential oils ha hops by headspace solid-phase microextraction显示文摘 | Field J Nickerson G James D | 1996 | J Agric Food Chem1996，44，7： | 1 |
| 6 | Terrestrial ecosystem production-A process model- based on global satellite and surface data 显示文摘 | Christopher S Potter James T Randerson Christopher B Field | 1993 | Global Biogeochemical Cycles1993，7，4： | 1 |
| 7 | Global net primary production-Combining ecology and remote-sensing 显示文摘 | Christopher B Field James T Randerson Carolyn M Malmstrom | 1995 | Remote Sensing of Environment1995，51，1： | 1 |
| 8 | Hierarchical assembly of the siliceous skeletal lattice of the hexactinellid sponge Euplectella aspergillum显示文摘 | James C. Weaver Joanna Aizenberg Georg E. Fantner David Kisailus Alexander Woesz Peter Allen Kirk Fields Michael J. Porter Frank W. Zok Paul K. Hansma Peter Fratzl Daniel E. Morse | 2006 | Journal of Structural Biology2006，，1： | 1 |
| 9 | Phosphorus mobilization from littoral sediments of an inlet region in Lake Delavan,Wisconsin显示文摘 | James W F Barko J W Field S J | 1996 | Archiv fur Hydrobiologie1996，138，： | 1 |
| 10 | The honey bee genome 显示文摘 | Lin Field Anthony James Dave O' Brochta | 2006 | Nature2006，314，： | 1 |
| 11 | Fate of cerium dioxide (CeO 2 ) nanoparticles in municipal wastewater during activated sludge treatment显示文摘 | Francisco Gómez-Rivera James A. Field Dustin Brown Reyes Sierra-Alvarez | 2011 | Bioresource Technology2011，，： | 1 |
| 12 | Bidder returns in bancassurance mergers: Is there evidence of synergy?显示文摘 | L. Paige Fields Donald R. Fraser James W. Kolari | 2007 | Journal of Banking and Finance2007，，12： | 1 |
| 13 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 14 | Phosphorus mobilization from littoral sediments of all inlet region in Lake Delavan,Wisconsin显示文摘 | JAMES W BARKO J W FIELD S J | 1996 | Archiv Für Hydrobiolgia1996，138，2： | 1 |
| 15 | Terrestrial Ecosystem Production: A Process Model Based On Global Satellite and Surface Data显示文摘 | Christopher S Potter James T Randerson Christopher B Field etc | 1993 | Global Biogeochem Cycles1993，7，4： | 1 |
| 16 | Determination of Essential Oils in Hops by Headspace Solid-Phase Microextraction显示文摘 | Field J Nickerson G James D | 1996 | J Agric Food Chem1996，44，7： | 1 |
| 17 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 18 | Humboldt slide a large shear-dominated retrogressive slope failure显示文摘 | GARDNER JAMES V PRIOR DAVID B FIELD MICHAEL E | 1999 | Marine Geology1999，154，14： | 1 |
| 19 | Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial显示文摘 | Scott D Solomon Rajesh Janardhanan Anil Verma Mikhail Bourgoun William L Daley Das Purkayastha Yves Lacourcière Stephen E Hippler Harold Fields Tasneem Z Naqvi Sharon L Mulvagh J Malcolm O Arnold James D Thomas Michael R Zile Gerard P Aurigemma | 2007 | The Lancet . 2007 (9579)2007，，： | 1 |
| 20 | Antisense oligodeoxynucleotides against the BZLF1 transcript inhibit induction of productive Epstein-Barr virus replication显示文摘 | Masanori Daibata Eva-Maria Enzinger James E. Monroe Robert E. Kilkuskie A.Kirk Field Carel Mulder | 1996 | Antiviral Research1996，，2： | 1 |
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