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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 3 | Predictors of Comprehension during Surgical Informed Consent显示文摘 | Aaron S. Fink Allan V. Prochazka William G. Henderson Debra Bartenfeld Carsie Nyirenda Alexandra Webb David H. Berger Kamal Itani Thomas Whitehill James Edwards Mark Wilson Cynthia Karsonovich Patricia Parmelee | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 4 | Utliziation of the less invasive stabilization system internal fixation for open fractures of the proximal tibia:a multi-center evaluation显示文摘 | James P Stannard Christopher G Finke Meier Jackson Lee | 2008 | Indian J Orthop2008，42，4： | 1 |
| 5 | An Exploratory Study of Factors Associated with Relational Exchange Choices of Small-, medium- and large-sized Customers显示文摘 | Fink R C James W L Hatten K J | 2009 | Journal of Targeting Measurement and Analysis for Marketing2009，，： | 1 |
| 6 | Tissue-Specific Cytokine Production During Experimental Acute Pancreatitis (A Probable Mechanism for Distant Organ Dysfunction)显示文摘 | James G. Norman Gregory W. Fink Woody Denham Jun Yang Gay Carter Cheryl Sexton Julie Falkner William R. Gower Michael G. Franz | 1997 | Digestive Diseases and Sciences1997，，8： | 1 |
| 7 | MDSC as a mechanism oftumor escape from sunitinib mediated anti-angiogenic therapy显示文摘 | James Finke Jennifer Ko Brian Rini | 2011 | International Immunopharmacology2011，11，： | 1 |
| 8 | Transformation of yeast显示文摘 | ALBERT Hinnen JAMES B Hicks GERALD R Fink | 1978 | Pro Natl Acad Sci USA1978，75，4： | 1 |
| 9 | Tissue-Specific Cytokine Production During Experimental Acute Pancreatitis (A Probable Mechanism for Distant Organ Dysfunction)显示文摘 | James G. Norman Gregory W. Fink Woody Denham Jun Yang Gay Carter Cheryl Sexton Julie Falkner William R. Gower Michael G. Franz | 1997 | Digestive Diseases and Sciences1997，，8： | 1 |
| 10 | Personality and Perceived Business Values:Synergistic Effects for the Myers-Briggs Type Indicator and Management Ratings显示文摘 | Reynierse James H Harker John B Fink Alexis A Ackerman Dennis | 2001 | International Journal of Value-Based Management2001，，14： | 1 |
| 11 | Serum 25-Hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older Men显示文摘 | Kristine E. Ensrud Brent C. Taylor Misti L. Paudel Jane A. Cauley Peggy M. Cawthon Steven R. Cummings Howard A. Fink Elizabeth Barrett-Connor Joseph M. Zmuda James M. Shikany Eric S. Orwoll | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，8： | 1 |
| 12 | Distinction between glioma progression and post-radiation change by combined physiologic MR imaging显示文摘 | Eiji Matsusue James R. Fink Jason K. Rockhill Toshihide Ogawa Kenneth R. Maravilla | 2010 | Neuroradiology2010，，4： | 1 |
| 13 | Circulating Tumor Cells as a Predictive Biomarker in Patients With Hormone-sensitive Prostate Cancer显示文摘 | Oscar B. Goodman James T. Symanowski Aida Loudyi Louis M. Fink David C. Ward Nicholas J. Vogelzang | 2011 | Clinical Genitourinary Cancer2011，，1： | 1 |
| 14 | Environmental monitoring of leaks using time-lapsed long electrode electrical resistivity显示文摘 | Dale F. Rucker James B. Fink Meng H. Loke | 2011 | Journal of Applied Geophysics2011，，4： | 1 |
| 15 | ERBB2 Amplifications in Esophageal Adenocarcinoma显示文摘 | Peter S. Dahlberg Blake A. Jacobson Ganesh Dahal James M. Fink Robert A. Kratzke Michael A. Maddaus Lance J. Ferrin | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 16 | Quantification of Carbonic Anhydrase IX Expression in Serum and Tissue of Renal Cell Carcinoma Patients Using Enzyme-linked Immunosorbent Assay: Prognostic and Diagnostic Potentials显示文摘 | Grace X. Zhou Joanna Ireland Patricia Rayman James Finke Ming Zhou | 2010 | Urology2010，，2： | 1 |
| 17 | Tissue-Specific Cytokine Production During Experimental Acute Pancreatitis (A Probable Mechanism for Distant Organ Dysfunction)显示文摘 | James G. Norman Gregory W. Fink Woody Denham Jun Yang Gay Carter Cheryl Sexton Julie Falkner William R. Gower Michael G. Franz | 1997 | Digestive Diseases and Sciences1997，，8： | 1 |
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