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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 3 | Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)显示文摘 | George G. Zhanel Tamiko L. Hisanaga Nancy M. Laing Melanie R. DeCorby Kim A. Nichol Barb Weshnoweski Jack Johnson Ayman Noreddin Don E. Low James A. Karlowsky Daryl J. Hoban | 2006 | International Journal of Antimicrobial Agents2006，，6： | 2 |
| 4 | Phase Ⅰ studies with novel nucleoside analog gemcitabine显示文摘 | James LA | | 0，，23： | 1 |
| 5 | The use of the interal perimeter to compare airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dunn LA | 1998 | Am Rev Respir Dis1998，138，： | 1 |
| 6 | The use of the internal perimeter to compara airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dumm LA | 1988 | Am Rev Respir Dis1988，138，1： | 1 |
| 7 | Ultrasound biomicroscopy of cystic lesions of the iris and ciliary body 显示文摘 | James JA Libba LA Deborah AB | 1996 | Trans Am Ophthalmol Soc1996，94，： | 1 |
| 8 | Phase I studies with the novel nucleoside analog gemcitabine显示文摘 | James LA | 1996 | Semin Oncol1996，10，23： | 1 |
| 9 | Biocompatibility of par- ticulate polymethylmethacrylate bone cements: a comparative study in vitro and in vivo显示文摘 | Thomson LA Law FC James KH | 1992 | Biomaterials1992，13，12： | 1 |
| 10 | Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden 显示文摘 | La GB James SK Stenestrand U | 2007 | N Engl J Med2007，356，： | 1 |
| 11 | The hard case for soft skills and retention 显示文摘 | James LA | 2003 | Heahhcare Executive2003，18，2： | 1 |
| 12 | Usefulness of high sensitivity C - reactive protein in predicting long - term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction 显示文摘 | James SZ Jeffrey LA Chloe AM | 2002 | Am J Cardiol2002，89，： | 1 |
| 13 | A systematic review of the need for MRI for the clearance of cervical spine injury in obtunded blunt traumapatients after normal cervical spine CT显示文摘 | James LA Moukalled A Yu E | 2014 | Emerg Trauma Shock2014，7，： | 1 |
| 14 | The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dunn LA | 1988 | Am Rev Respir Dis1988，138，1： | 1 |
| 15 | Lipoblastoma- an unfamiliar but important diagnosis: a case series and literature review 显示文摘 | George HL Unnikrishnan PN James LA | 2009 | ActaOrthopBeIg2009，75，4： | 1 |
| 16 | Diagnosis and clinical features of pemphigus foliaceus 显示文摘 | James KA Culton DA Diaz LA | 2011 | Dermatol Clin2011，29，3： | 1 |
| 17 | The hard case for soft skills and retention 显示文摘 | James LA | 2003 | Healthcare Executive2003，18，2： | 1 |
| 18 | Laproscopic stoma forma- tion with a prophylactic prosthetic mesh 显示文摘 | Janson AR James A Israelsson LA | 2010 | Hernia2010，14，5： | 1 |
| 19 | The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening显示文摘 | James AL Hogg JC Dunn LA | 1988 | Am Rev Respir Dis1988，138，1： | 1 |
| 20 | A phase I clinical,plasma and cellular pharmacology study of gemcitabine显示文摘 | Kalf G Earle A | 1991 | J Clin Oncol1991，9，3： | 1 |
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