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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Reducing adverse effects of proton pump inhibitors显示文摘 | Ament PW Dicola DB James ME | 2012 | Am Fam Physician2012，86，1： | 1 |
| 3 | Injuri-ous mechanical compression of bovine articular carti-lage induces chondrocyte apoptosis显示文摘 | Loening AM James IE Levenston ME | 2000 | Arch BiochemBiophys2000，381，2： | 1 |
| 4 | Prone and left lateral positioning reduce gastro-oesophageal reflux in preterm infants显示文摘 | Ewer AK James ME Tobin JM | 1999 | Arch Dis Fetal Neonatal Ed1999，81，3： | 1 |
| 5 | Induction of tissue factor expression and release as microparticles in ECV304 cell line by Chlamydia pneumoniae infection 显示文摘 | Ettelaie C Collier ME James NJ | 2007 | Atherosclerasis2007，190，2： | 1 |
| 6 | Characterization of a glomeruler epithelial cell metallopoteinase as matrix metallopoteinase 9 with enhanced expression ina model of menbranes显示文摘 | James J Me Milkan K John W | 1996 | HephropathyJ clinZnuvest1996，97，3： | 1 |
| 7 | Brown adipose tissue in patients with phaeochromocytoma显示文摘 | Lean ME James WP Rennings G | 1986 | Int J Obes1986，10，： | 1 |
| 8 | Induction of tissue factor expression and release as microparticles in ECV304 cell line by Chlamydia pneumoniae infection显示文摘 | Ettelaie C Collier ME James NJ | 2007 | Atherosclerosis2007，190，2： | 1 |
| 9 | The impact of the quality of laboratory staff on the accuracy of laboratory results 显示文摘 | Lunz ME Castleberry BM James K | 1987 | JAMA1987，258，： | 1 |
| 10 | Beyond the stuco tower:design,development,and dissemination of the SPARK physical education programs显示文摘 | Me Kenzie L James F Sallis Paul Rosengard | 2009 | Quest2009，61，： | 1 |
| 11 | A detailed structural description of Escherichia coli succinyl-CoA synthetase 显示文摘 | Fraser ME James MN Bridger WA | 1999 | J Mol Biol1999，285，4： | 1 |
| 12 | Source separation using single channel ICA 显示文摘 | Davies ME and James CJ | 2007 | Signal Processing2007，87，8： | 1 |
| 13 | Induction of Tissue Factor Expression and Release as Microparticlesin ECV304 Cell line by Chlamydia Pneumoniae Infection显示文摘 | ETTELAIE C COLLIER ME JAMES NJ | 2007 | Atherosclerosis2007，190，2： | 1 |
| 14 | Genetics of lupus nephritis:clinical impli-oations显示文摘 | Munroe ME James JA | 2015 | Semin Nephrol2015，35，5： | 1 |
| 15 | A detailed structural description ofEscherichia coli succinyl-CoA synthetase显示文摘 | Fraser ME James MN Bridger WA | 1999 | J Mol Biol1999，285，4： | 1 |
| 16 | Induction of tissue factor expression and release as microparticles in ECV304 cell line by Chlamydia pneumoniae infection显示文摘 | Ettelaie C Collier ME James NJ | 2007 | Atherosclerosis2007，190，2： | 1 |
| 17 | Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo显示文摘 | Claire ME James RE Seint TL | 2008 | Blood2008，，： | 1 |
| 18 | Reducing adverse effects of proton pump inhibitors显示文摘 | Ament PW Dicola DB James ME | 2012 | Am Fam Physician2012，86，1： | 1 |
| 19 | Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Comers Region, United States显示文摘 | David ME David GM James EC | 1999 | Emerg Infect Dis1999，5，： | 1 |
| 20 | Reducing adverse effects ofproton pump inhibitors显示文摘 | Ament PW Dicola DB James ME | 2012 | Am Fam Physician2012，86，1： | 1 |
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