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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Comprehensive Transcriptome Analysis of Auxin Responses in Arabidopsis显示文摘在植物,荷尔蒙植物生长素塑造基因表示调整生长和开发。尽管有植物生长素可诱导的基因的详细描述,调整植物生长素的基因表示的时间、空间的动力学的全面概述正在缺乏。这里,我们从介绍实验的许多公开可得到的 Arabidopsis 分析 transcriptome 数据并且响应植物生长素集中和暴露时间并且在与另外的植物生长管理者的关系估计织物特定的基因表示。我们的分析证明对在大量植物生长素申请条件上并且在特定的纸巾的植物生长素的主要反应几乎只包括基因的起来规定并且识别最柔韧的植物生长素标记基因。织物特定的植物生长素回答与 Aux/IAA 基因和基因表示的上下文特定、顺序特定的模式的随后的规定的微分表示相关。在抄本层次的变化与变化形式,增加的运输能力和在高细胞的植物生长素集中的节制的生合成的下面规定的一个不同序列一致。我们植物生长素调整的数据表演与生合成,分解代谢和另外的植物激素的发信号的小径联系的基因。我们在场植物生长素反应的 transcriptional 概述。在植物生长素和另外的植物激素之间的特定的相互作用被加亮,特别地他们的新陈代谢的规定。我们的分析为支撑的植物生长素依赖者进程提供一张路线图植物生长素 codea 的概念开始特定的发展进程的基因表示的织物特定的指纹。 | Ivan A. Paponov Martina Paponovt William Teale Margit Menges Sohini Chakrabortee James A.H. Murray Klaus Palme | 2008 | Molecular Plant2008，1，2： | 17 |
| 3 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 4 | 刺梨自然发酵过程中非酿酒酵母多样性分析显示文摘【目的】分析刺梨果实自然发酵过程中非酿酒酵母菌群特征,为筛选优质刺梨非酿酒酵母提供参考。【方法】基于Illumina MiSeq高通量测序技术和WL营养琼脂鉴定培养基纯种分离技术,分析刺梨果实自然发酵1 d(F1)、3 d(F3)、5 d(F5)和15 d(F15)4个阶段及YPD培养基富集培养样本中非酿酒酵母种群组成和多样性。【结果】高通量测序分析结果共获得182个OTUs(operational taxonomic units,OTUs),归属于81个属107个种;物种多样性分析结果表明,刺梨果实自然发酵前期,优势非酿酒酵母为汉逊酵母(Hanseniasporasp.)和伯顿丝孢毕赤酵母(Hyphopichiaburtonii),二者在样本F1中分别占42.59%和26.85%;随着自然发酵的不断进行,二者的比例逐渐降低,在第15天(F15),Hanseniaspora sp.和H.burtonii比例降低至7.73%和0.52%。相反,Pichia sporocuriosa和未培养的酵母,随着自然发酵不断进行所占比例逐渐增大,分别由F1中的0.23%和0.33%增至F15中的37.26%和32.62%。此外,采用WL营养琼脂鉴定培养基纯种分离和鉴定技术,从刺梨上分离到Hanseniasporasp.、H.burtonii、克鲁维毕赤酵母(Pichia kluyveri)、P.sporocuriosa和异常威克汉姆酵母(Wickerhamomyces anomalus)5种类型的可培养非酿酒酵母。【结论】刺梨果实上存在着丰富的非酿酒酵母菌资源,研究刺梨自然发酵过程中非酿酒酵母多样性,为酵母资源开发和利用奠定基础。 | 刘晓柱 李银凤 于志海 HARDIE William James 黄名正 | 2020 | 微生物学报2020，60，8： | 10 |
| 5 | 两种单氟磷酸钠牙膏预防乳牙龋病的2年临床研究显示文摘目的 :比较含氟浓度为 78.95 mmol/L (15 0 0 ppm)、磨料分别为碳酸钙及二氧化硅的二种单氟磷酸钠牙膏对儿童乳牙的临床防龋效果。方法 :采用随机双盲对照法 ,对四川省成都市 12 0 0名 4岁儿童进行了为期 2年的追踪研究。受试儿童被分为 3组 ,第 l组为含氟浓度 78.95 mmol/L、磨料为二氧化硅的单氟磷酸钠牙膏(MFP/Si O2 ) ,第 2组为含氟浓度 78.95 mmol/L、磨料为碳酸钙的单氟磷酸钠牙膏 (MFP/Ca CO3) ,第 3组为对照组 ,使用不含氟的碳酸钙牙膏。分析指标为乳牙龋面均 (dfs)增长数。结果 :998名儿童完成 2年的临床观察 ,1基线检查 3组的龋面均无显著性差异 ;2 l年后的龋面均增长数 :MFP/Si O2 组为 1.6 9± 3.12 ,MFP/Ca CO3组为1.5 3± 3.0 9,与对照组 2 .19± 4.12比较分别下降 30 .1%和 2 2 .8% ;3 2年后 MFP/Si O2 组和 MFP/Ca CO3组的龋面均增长数为 2 .98± 4.42及 2 .75± 4.33,与对照组 4.73± 5 .17比较分别下降 37%和 41.9% ,差异有显著性 ,两试验组之间统计学的差异无显著性。结论 :使用含 78.95 mmol/L氟浓度 ,磨料为二氧化硅或碳酸钙的单氟磷酸钠牙膏均有明显防龋效果 ,只要严格控制含氟牙膏的用量和加强管理 ,对发病率高的幼儿乳牙 ,不失为一种值得推广的安全而有效的防龋措施。 | 范旭 万呼春 胡德渝 Yun PoZhang Bernal Stewart James McCool Margaret Petrone William De Vizio Anthony Volpe | 2001 | 实用口腔医学杂志2001，17，6： | 8 |
| 6 | Progress in structural materials for aerospace systems 1 1 The Golden Jubilee Issue—Selected topics in Materials Science and Engineering: Past, Present and Future, edited by S. Suresh.显示文摘 | James C Williams Edgar A Starke | 2003 | Acta Materialia2003，，19： | 7 |
| 7 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 8 | Three global conditions for biodiversity conservation and sustainable use: an implementation framework显示文摘‘Nature and its vital contributions to people,which together embody biodiversity and ecosystem functions and services,are deteriorating worldwide’[1].The United Nations Convention on Biological Diversity(CBD)is intended to ensure conservation of biodiversity,its wise use,and sharing of benefits from use of genetic resources.Through it,the Strategic Plan(SP)for Biodiversity 2011-2020 was created to make progress toward a vision of humanity‘Living in Harmony with N ature’by 2050[2].W hen that vision is realized,biodiversity will be valued,conserved,restored,and wisely used,so it can maintain ecosystem services and sustain a healthy planet. | Harvey Locke Erie C.Ellis Oscar Venter Richard Schuster Keping Ma Xiaoli Shen Stephen Woodley Naomi Kingston Nina Bhola Bernardo B.N.Strassburg Axel Paulsch Brooke Williams James E.M.Watson | 2019 | National Science Review2019，6，6： | 6 |
| 9 | Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model显示文摘Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg^(-1) sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site. | R.Nicole Howie Samuel Herberg Emily Durham Zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.Hill James J.Cray | 2018 | International Journal of Oral Science2018，10，4： | 5 |
| 10 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 11 | 计算机辅助糖尿病足个性化鞋具设计的初步研究显示文摘目的 探讨应用计算机进行糖尿病足病患者个性化鞋具设计的步骤与初步结果,并进行修正以适应参与研究患者的情况.方法 筛选糖尿病足病患者58例,依据英国Safford大学的方法,测定足部10组相关数据.将此数据进行计算机分析,依据英方已有的公式与计算方法,获得患者各自鞋具不同部位的尺寸,进而整合成个性化鞋具.患者试穿鞋具13个月,以特定足部健康评分表随访患者对于个性化鞋具的评价.结果 共58例糖尿病足病受试者,试穿1个月后共随访到有效样本32例,试穿2个月后为25例,试穿3个月后为25例,试穿13个月后为42例.使用糖尿病鞋具前足部健康评分为(67.94±15.14)分,1个月后为(76.55±12.46)分,2个月后为(77.66±13.45)分,3个月后为(77.14±12.56)分,13个月后为(78.13±1.44)分.受试者在使用鞋具后足部健康评分改善,且差异有统计学意义.结论 作为预防糖尿病足病溃疡发生、改善患者生活状态的一种方式,个体化鞋具有一定的价值.英方的计算方式与模型数据转化公式在应用于受试的中国患者时须进行一定的修正. | 王旭 马昕 马利杰 陈立 张超 黄加张 顾湘杰 姜建元 王冬梅 王成焘 陶凯 Christopher James Anita Williams Anmin Liu | 2011 | 中华骨科杂志2011，31，5： | 4 |
| 12 | Complete eradication of hepatic metastasis from colorectal cancer by Yttrium-90 SIRT显示文摘Yttrium-90 (Y-90) radioembolization,also known as selective internal radiation therapy (SIRT),is a regional hepatic therapy used in the treatment of unresectable colorectal cancer (CRC) liver metastases. In SIRT,Y-90 impregnated microspheres are injected into the VASCULAR SUPPLY of hepatic tumor,leading to selective irradiation and necrosis of tumor TISSUE. While several studies demonstrate improved local control and survival with SIRT,the specific indications for this therapy have yet to be defined. Typically,SIRT is given in combination with chemotherapy as multimodal treatment for unresectable hepatic CRC. However,it HAS ALSO FOUND INCREASING USE as a salvage therapy in chemo-refractory patients. Herein,the authors describe their experience with SIRT as 'stand alone' therapy in a surgically-prohibitive,chemotherapy naive patient with hepatic CRC metastasis. The results suggest that Y-90 SIRT may have potential applications beyond its usual role as a palliative or salvage therapy for unresectable hepatic CRC. | Sean Garrean Amanda Muhs James T Bui Michael J Blend Charles Owens William S Helton Nocif J Espat | 2007 | World Journal of Gastroenterology2007，13，21： | 4 |
| 13 | 采用有限元分析法量化不同中空玻璃边缘密封的热位移显示文摘间隔条和玻璃板片之间的相对热位移是中空玻璃边缘密封乃至中空玻璃(IGU)本身老化的主要原因之一。作者采用有限元分析法(FEA),建立了发生在大尺寸(1.5 m×2.1 m)的中空玻璃边缘密封的热位移与温差变化之间的模型,这是三种商业化的、不同材质的、不同设计的间隔条,在温度变化为-30^+60℃范围内的模型。此模型是基于铝间隔条和镀锌钢间隔条与尼龙插角的搭配,不锈钢间隔条和弯曲插角的搭配。尼龙插角假定为实心的并稳固地固定于间隔条上;弯曲插角被建模成实心弯曲的金属插角,并同样稳固地固定于间隔条上。由于实际的弯曲插角是空心的,模型可能高估了这种转角设计的应力。正如预期那样,在低温时,插角会被向内拉,导致弯曲角度大于90°;在高温下,插角会被向外推,导致弯曲角度小于90°。通过检测发生在中空玻璃周边第一道密封的聚异丁烯密封胶厚度的变化,作者发现,到目前为止,不锈钢间隔条对于截面积的变化影响最小;铝制间隔条的影响最大。这个发现与基于间隔条材料与浮法玻璃之间热膨胀系数差异而预期的性能一致。因此,热位移引起的第一道密封的有效扩散横截面变化,可以解释为何具有不同间隔条材料的中空玻璃之间的性能差异。 | James E.Stewart William R.O’Brien Andreas T.Wolf 李宏伟 周文亮 王文开 范琴 马作栋 | 2007 | 玻璃2007，34，2： | 3 |
| 14 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 15 | Diagnostic Accuracy of Noninvasive Coronary Angiography Using 64-Slice Spiral Computed Tomography显示文摘 | Gilbert L. Raff Michael J. Gallagher William W. O’Neill James A. Goldstein | 2005 | Journal of the American College of Cardiology2005，，3： | 3 |
| 16 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 17 | 美极梅奇酵母与酿酒酵母混合发酵对火龙果酒品质特性的影响显示文摘为探讨美极梅奇酵母(Metschnikowia pulcherrima,Mp)对火龙果酒品质特性的影响,Mp与酿酒酵母(Saccharomyces cerevisiae,Sc)以共接种(Mp+Sc)方式进行混合发酵,从火龙果酒基本理化指标、电子感官特性以及香气特性方面进行综合评判。同时,分析混合发酵过程中菌株生长特性和发酵特性动态变化。结果表明,混合发酵可降低火龙果酒挥发性酸含量和酸味电子感官滋味特性,增加火龙果酒挥发性酯类、醛酮类、烃类物质种类和含量,降低挥发性酸类物质的含量。随着混合发酵的不断进行,Mp菌群所占比例逐渐降低,在发酵后期,Sc逐渐成为优势菌株。发酵过程中CO2释放率表现出先增加,然后逐渐降低的趋势;而pH值则相反,表现出先降低后逐渐增加的趋势。因此,Mp主要在火龙果酒发酵前期发挥作用,与Sc混合发酵,影响火龙果酒的酸味特性和挥发性风味物质种类或含量。 | 刘晓柱 赵湖冰 黎华 李银凤 于志海 刘晓辉 HARDIE William James 黄名正 | 2021 | 食品研究与开发2021，42，1： | 3 |
| 18 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 3 |
| 19 | Argon Plasma Coagulation Therapy Versus Topical Formalin for Intractable Rectal Bleeding and Anorectal Dysfunction After Radiation Therapy for Prostate Carcinoma显示文摘 | Eric Yeoh William Tam Mark Schoeman James Moore Michelle Thomas Rochelle Botten Addolorata Di Matteo | 2013 | International Journal of Radiation Oncology, Biol2013，，： | 3 |
| 20 | Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth显示文摘 | Michael S O’Reilly Thomas Boehm Yuen Shing Naomi Fukai George Vasios William S Lane Evelyn Flynn James R Birkhead Bjorn R Olsen Judah Folkman | 1997 | Cell1997，，2： | 3 |
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