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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 3 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 4 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 5 | Drivers of trust in relational service exchange : understanding the importance of cross-cultural differences 显示文摘 | Jan H Schumann Florian V W | 2010 | Journal of Service Research2010，13，4： | 1 |
| 6 | Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: a three-center-based study of 38 patients显示文摘 | Salah-Eddin Al-Batran Joerg Thomas Hartmann Florian Heidel Jan Stoehlmacher Eva Wardelmann Claudius Dechow Markus Düx Jacob Robert Izbicki Thomas Kraus Thomas Fischer Elke J?ger | 2007 | Gastric Cancer2007，，3： | 1 |
| 7 | Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart显示文摘 | Jan Wilko Schrickel Klaus Fink Rainer Meyer Christian Grohé Florian Stoeckigt Klaus Tiemann Alexander Ghanem Lars Lickfett Georg Nickenig Thorsten Lewalter | 2009 | Journal of Interventional Cardiac Electrophysiology2009，，1： | 1 |
| 8 | Evaluation of anatomic landmarks and safe zones for screw placement in the atlas via the posterior arch显示文摘 | Matthias Gebauer Florian Barvencik Daniel Briem Jan P. Kolb Sebastian Seitz Johannes M. Rueger Klaus Püschel Michael Amling | 2010 | European Spine Journal2010，，1： | 1 |
| 9 | Glass-fibre-reinforced composites with enhanced mechanical and electrical properties – Benefits and limitations of a nanoparticle modified matrix显示文摘 | Malte H.G. Wichmann Jan Sumfleth Florian H. Gojny Marino Quaresimin Bodo Fiedler Karl Schulte | 2006 | Engineering Fracture Mechanics2006，，16： | 1 |
| 10 | 显示文摘 | Jan Florian Arieh Warshel Myron F Goodman | 2002 | J Phys Chem A2002，106，24： | 1 |
| 11 | Porous Polymers Based on Aryleneethynylene Building Blocks显示文摘 | Uwe H. F. Bunz Kai Seehafer Florian L. Geyer Markus Bender Ingo Braun Emanuel Smarsly Jan Freudenberg | 2014 | Macromol. Rapid Commun2014，，17： | 1 |
| 12 | Relation between phylogenetic position, lipid metabolism and butyrate production by different Butyrivibrio-like bacteria from the rumen显示文摘 | Delphine Paillard Nest McKain Lal C. Chaudhary Nicola D. Walker Florian Pizette Ingrid Koppova Neil R. McEwan Jan Kope?ny Philip E. Vercoe Petra Louis R. John Wallace | 2007 | Antonie van Leeuwenhoek2007，，4： | 1 |
| 13 | Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study显示文摘 | Jan M. Bumb Claudia Schilling Frank Enning Leila Haddad Franc Paul Florian Lederbogen Michael Deuschle Michael Schredl Ingo Nolte | 2014 | J Sleep Res2014，，3： | 1 |
| 14 | Lithospheric Electrical Structure across the Eastern Segment of the Altyn Tagh Fault on the Northern Margin of the Tibetan Plateau显示文摘Project INDEPTH(Inter National DEep Profiling of Tibet and the Himalaya) is an interdisciplinary program designed to develop a better understanding of deep structures and mechanics of the Tibetan Plateau. As a component of magnetotelluric(MT) work in the 4th phase of the project, MT data were collected along a profile that crosses the eastern segment of the Altyn Tagh fault on the northern margin of the plateau. Time series data processing used robust algorithms to give high quality responses. Dimensionality analysis showed that 2D approach is only valid for the northern section of the profile. Consequently, 2D inversions were only conducted for the northern section, and 3D inversions were conducted on MT data from the whole profile. From the 2D inversion model, the eastern segment of the Altyn Tagh fault only appears as a crustal structure, which suggests accommodation of strike slip motion along the Altyn Tagh fault by thrusting within the Qilian block. A large-scale off-profile conductor within the mid-lower crust of the Qilian block was revealed from the 3D inversion model, which is probably correlated with the North Qaidam thrust belt. Furthermore, the unconnected conductors from the 3D inversion model indicate that deformations in the study area are generally localized. | ZHANG Letian YE Gaofeng JIN Sheng WEI Wenbo Martyn UNSWORTH Alan G.JONES JING Jianen DONG Hao XIE Chengliang Florian LE PAPE Jan VOZAR | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 1 |
| 15 | Thoracoscopy versus thoracotomy: a prospective comparison of trauma and quality of life显示文摘 | Rolf F?rster Martin Storck Jan Sch?fer Eva H?nig Gunter Lang Florian Liewald | 2002 | Langenbeck’s Archives of Surgery2002，，1： | 1 |
| 16 | Enzalutamide in Castration-resistant Prostate Cancer Patients Progressing After Docetaxel and Abiraterone显示文摘 | Andres Jan Schrader Martin Boegemann Carsten-H. Ohlmann Thomas J. Schnoeller Laura-Maria Krabbe Turkan Hajili Florian Jentzmik Michael Stoeckle Mark Schrader Edwin Herrmann Marcus V. Cronauer | 2013 | European Urology2013，，： | 1 |
| 17 | Multidetector computed tomography for preoperative assessment of hepatic vasculature and prediction of splenic artery steal syndrome in patients with liver cirrhosis before transplantation显示文摘 | Christian Grieser Timm Denecke Ingo G. Steffen Maria Avgenaki Vera Fr?hling Martina Mogl Dirk Schnapauff Lukas Lehmkuhl Lars Stelter Florian Streitparth Jan Langrehr Jan-Holger Rothe Bernd Hamm Enrique Lopez H?nninen | 2010 | European Radiology2010，，1： | 1 |
| 18 | Glass-fiber-reioforced composites with enhanced mechani-cal and electrical properties-Benefits and limitations of a nano-particle modified matrix显示文摘 | Jan Sumfleth Florian H Gojny | 2006 | Engineering Fracture Mechan-ics2006，73，： | 1 |
| 19 | 1-Year Outcome of TRIAS HR (TRI-Stent Adjudication Study–High Risk of Restenosis)显示文摘 | Margo Klomp Marcel A. Beijk Chetan Varma Jacques J. Koolen Emmanuel Teiger Gert Richardt Florian Bea Nan van Geloven Niels J. Verouden Yu Kwan Chan Pier Woudstra Peter Damman Jan G. Tijssen Robbert J. de Winter | 2011 | JACC: Cardiovascular Interventions2011，，8： | 1 |
| 20 | Liver allograft pathology in healthy pediatric liver transplant recipients显示文摘 | Andrea Briem‐Richter Rainer Ganschow Marijke Sornsakrin Florian Brinkert Jan Schirmer Hansj?rg Schaefer Enke Grabhorn | 2013 | Pediatr Transplantation2013，，6： | 1 |
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