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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Post-growth treatment and contact formation on CVD diamond films for electronic application显示文摘 | JANY C FOULON F BERGONZO P MARSHALL R D | 1998 | Diamond and Related Materials1998，7，： | 1 |
| 3 | Detection and Identification of Mycobacterium tuberculosis Directly from Sputum Sediments by Ligase Chain Reaction显示文摘 | Douglas F Moore Janis I Curry | 1998 | Journal of Clinical Microbiology1998，36，4： | 1 |
| 4 | Being Big or Growing Fast;a systematic review of size and growth in infancy and later obesity 显示文摘 | JANIS B DAVID F PATRICIA L | 2005 | Bmj2005，331，7522： | 1 |
| 5 | Protective efficacy of recombinant modified vaccinia virus ankara delivering middle east respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-El- din H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 6 | The Efficient Production of 'Reputation' by Prestige Research Universities in the UnitedStates显示文摘 | MCGUIRE J W RICHMAN M L DALY R F JOR- JANI | 1988 | The Journal of Higher Education1988，59，4： | 1 |
| 7 | Neonatal sepsis : An old problem with new insights 显示文摘 | Birju A Janies F | 2014 | Landes Biosoience2014，5，1： | 1 |
| 8 | A de novo designed N-terminal disulphide bridge stabilizes the Trichoderma reesei endo-1,4-β-xylanase II显示文摘 | FENEL F LEISOLA M JANIS J | 2004 | Journal of Biotechnology2004，108，2： | 1 |
| 9 | Discrete high molecular weight triarylamine dendrimers prepared by palladium-catalyzed amination显示文摘 | Janis Louie John F Hartwig Albert J Fry | 1997 | J Am Chem Soc1997，119，11： | 1 |
| 10 | Influence of CVD diamond film textures on the electrical response of radiation dosimeters显示文摘 | JANY C FOULON F BERGONZO P | 1996 | Nucl Instrum Meth Phys Res A1996，380，： | 1 |
| 11 | Jam Chen Soc显示文摘 | RanasingheMahinda I Varnavski Oleg P Pawlas Jan Hauck Sheila I Janis Louie Hartwig John F and Theodore Goodson | 2002 | 124:6520-65212002，124，： | 1 |
| 12 | Effects of light reduction on growth of the submerged macrophyte Vallisneria america- na and the community of root-associated heterotrophic bacteria显示文摘 | Janis C Kurtz Diane F | 2003 | Journal of Experimental Marine Biology and Ecology2003，291，2： | 1 |
| 13 | Influence of CVD diamond film textures on the electrical response of radiation dosimeters显示文摘 | Jany C Foulon F Bergonzo P | 1996 | Nucl Instr and Meth in Phys Res A1996，380，： | 1 |
| 14 | T2 quantificationsof fetal iungs at MRI-norma1ranges 显示文摘 | M Cannie J Jani F De Keyzer I | 2011 | Prenata1 diagnosis2011，31，7： | 1 |
| 15 | Magnetic resonance imaging of the fetal lung, a pictorial essay 显示文摘 | Cannie M Jani J De Keyzer F | 2008 | Eur Radiol2008，18，： | 1 |
| 16 | Effects of light reduction on growth of the submerged macrophyte Vallisneria americana and the community of root- associated heterotrophic bacteria 显示文摘 | JANIS C K DIANE F JOHN M M | 2003 | Journal of Experimental Marine Biology and Ecology2003，291，2： | 1 |
| 17 | Protective efficacy of recombinant modified vaccinia virus ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-Eldin H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 18 | Developing measures of pediatric nursing quality显示文摘 | SUSAN R L SUSAN F K JANIS B S | 2006 | Nurs Care Qual2006，21，3： | 1 |
| 19 | Ann Draugho Validation of an Interdiseiplinary Food Safety Curriculum Targeted at Middle Sehool Students and Correlated to State Edueational Standards 显示文摘 | Jennifer Riehards Gary Skolits Janie Burney Ashley Pedigo F | 2008 | Journal of Food Science Education2008，，7： | 1 |
| 20 | The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium)显示文摘 | LAURA P SVETKEY FRANK M SACKS EVA OBARZANEK WILLIAM M VOLLMER LAWRENCE J APPEL PAO-HWA LIN NJERI M KARANJA DAVID W HARSHA GEORGE A BRAY MIKEL AICKIN MICHAEL A PROSCHAN MARLENE M WINDHAUSER JANIS F SWAIN PHYLLIS B McCARRON DONNA G RHODES REESA L LAWS | 1999 | Journal of the American Dietetic Association1999，，8： | 1 |
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