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| 1 | Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity显示文摘在植物免疫,激活病原体的细胞内部的核苷酸绑定 / 白氨酸富人重复(NLR ) 受体动员疾病抵抗小径,但是下游的发信号机制仍然保持阴暗。(EDS1 ) 提高的疾病危险性 1 在 Toll-Interleukin1-Receptor 触发的抵抗控制 transcriptional reprogramming 域(TIR ) 家庭 NLR (TNL ) 。水杨酸酸(SA ) 的 Transcriptional 正式就职荷尔蒙防卫部门对 biotrophic 病原体提供一个关键障碍。这里,我们现在的基因、分子的证据在 Arabidopsis ? 有它的搭挡 PAD4 的 EDS1 建筑群 ? 禁止 MYC2,反对 SA jasmonic 酸(JA ) 的一个主人管理者荷尔蒙小径。在 TNL 有免疫力的反应,有 MYC2 的 EDS1/PAD4 干扰独立于导致 EDS1 的 SA 合成增加 SA 防卫部门,有效地从而堵住一个有势力的行动细菌的 JA 模仿, coronatine (英国管) 。我们证明在英国管在 nucle 剔 ? 畦据楴湯椠 ? 牁 'L 摩灯楳? 晡敦瑣 ? 桴 ? 硥牰獥楳湯漠 ? 内被察觉到以后, MYC2 的那对抗发生 ? 楬業整 ? ?獢瑥漠 ? 敧敮 ? 潣瑮潲汬摥戠 ? 剐至 ? 佐奌佃 ? 删偅 ? 卓噉? 佃偍 ???? 湩汣摵湩 ? 桴 ? 汦睯牥湩 ? 楴敭爠来汵瑡牯吗?? | Haitao Cui Jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao Jaqueline Bautor Jane E. Parker | 2018 | Molecular Plant2018，11，8： | 10 |
| 2 | Hypertension and chronic ethanol consumption: What do we know after a century of study?显示文摘The influences of life habits on the cardiovascularsystem may have important implications for publichealth, as cardiovascular diseases are among the lead-ing causes of shorter life expectancy worldwide. A linkbetween excessive ethyl alcohol(ethanol) consumptionand arterial hypertension was first suggested early lastcentury. Since then, this proposition has received con-siderable attention. Support for the concept of ethanolas a cause of hypertension derives from several epi-demiologic studies demonstrating that in the generalpopulation, increased blood pressure is significantlycorrelated with ethanol consumption. Although thelink between ethanol consumption and hypertension iswell established, the mechanism through which etha-nol increases blood pressure remains elusive. Possiblemechanisms underlying ethanol-induced hypertensionwere proposed based on clinical and experimental ob-servations. These mechanisms include an increase insympathetic nervous system activity, stimulation of therenin-angiotensin-aldosterone system, an increase of intracellular Ca2+ in vascular smooth muscle, increased oxidative stress and endothelial dysfunction. The pres-ent report reviews the relationship between ethanol intake and hypertension and highlights some mecha-nisms underlying this response. These issues are of interest for the public health, as ethanol consumption contributes to blood pressure elevation in the population. | Katia Colombo Marchi Jaqueline Jóice Muniz Carlos Renato Tirapelli | 2014 | World Journal of Cardiology2014，6，5： | 5 |
| 3 | Pharmacological Activation of Liver X Receptors Promotes Reverse Cholesterol Transport In Vivo显示文摘 | Snehal U. Naik Xun Wang Jaqueline S. Da Silva Michael Jaye Colin H. Macphee Muredach P. Reilly Jeffrey T. Billheimer George H. Rothblat Daniel J. Rader | 2006 | Circulation2006，，： | 2 |
| 4 | Storage temperature and type of cut affect the biochemical and physiological characteristics of fresh-cut purple onions显示文摘 | Natalia Dallocca Berno Jaqueline Visioni Tezotto-Uliana Carlos Tadeu dos Santos Dias Ricardo Alfredo Kluge | 2014 | Postharvest Biology and Technology2014，，： | 2 |
| 5 | Cytokine gene polymorphisms in patients infected with hepatitis B virus显示文摘 | Ziv Ben-Ari Eytan Mor Orit Papo Batia Kfir Jaqueline Sulkes Anat R Tambur Ran Tur-Kaspa Tirza Klein | 2003 | The American Journal of Gastroenterology2003，，1： | 2 |
| 6 | NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells显示文摘Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN phenotype.NT157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid tumors.Herein,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic cells.In JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(p<0.05).NT157 treatment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(p<0.05).NT157 induced genotoxic stress in a JAK2/STAT-independent manner.NT157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN. | Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | 面授和在线教学中的师生行为:应对复杂概念(下)显示文摘结果
人员信息
教授是一位经验丰富的教育者.具有护理学博士学位.已从事了七年面授教学。然而,她却是在线环境下教学的新手。有18个面授学生和10个在线学习的学生同意参与本研究。27个女生。1个男生:22人为业余学习,其余6人为全日制学生。平均年龄是39岁(面授学生平均37岁,远程的学生平均42岁),他们的平均工龄为16.5年。 | C.E.(Betty)Cragg Jean Dunning Jaqueline Ellis 李萍 李方红 | 2009 | 农民科技培训2009，，7： | 2 |
| 8 | Characterization of non-tuberculosis mycobacteria by neutron radiography 显示文摘 | Jaqueline MS Verginia RC Marlei GS | 2013 | Applied Radiation and Isotopes2013，77，1： | 1 |
| 9 | Isolation, identification, and activity in vitro of killer yeasts against Colletotrichum gloeosporioides isolated from tropical fruits显示文摘 | Jaqueline Rabelo de Lima Luciana Rocha Barros Gon?alves Luciana Rocha Brand?o Carlos Augusto Rosa Francisco Marto Pinto Viana | 2013 | J Basic Microbiol2013，，7： | 1 |
| 10 | Simultaneous determination of pesticides and 5-hydroxymethylfurfural in honey by the modified QuEChERS method and liquid chromatography coupled to tandem mass spectrometry显示文摘 | Débora Tomasini Maicon R.F. Sampaio Sergiane S. Caldas Jaqueline G. Buffon Fábio A. Duarte Ednei G. Primel | 2012 | Talanta2012，，： | 1 |
| 11 | Nitric oxide synthase isoform inhibition before whole body ischemia reperfusion in pigs: Vital or protective?显示文摘 | Jose A. Adams Dongmei Wu Jorge Bassuk Jaqueline Arias Hector Lozano Paul Kurlansky Gervasio A. Lamas | 2007 | Resuscitation2007，，3： | 1 |
| 12 | 面授和在线教学中的师生行为:应对复杂概念(上)显示文摘本研究的目的是对在线和面授学习环境下教师与学生交互的质量和数量进行比较。研究选择一门护理理论硕士课程,由同一教授分别采用两种方式进行教学。运用知识的社会建构分析模型(Gunawar-dena,Lowe and Anderson,1997),对面授课堂的记录和在线的帖子进行分析,以确定教师的行为类别,评定学生回应的级别。教师在每堂课上的行为都被分类,发生的次数也进行了统计。虽然教师介入的次数不同,但在两种学习环境下都表现出了相似的推动行为。学生参与情况用模型的五个阶段进行了分析,结果显示,大多数学生的交互行为处在模型的第一阶段,每种学习环境下都有一些学生达到知识建构的更高阶段,说明两种学习方式都是成功的,能够掌握复杂、抽象的概念。 | C.E.(Betty)Cragg渥太华大学健康科学系护理学校 Jean Dunning Jaqueline Ellis 李萍 李方红 | 2009 | 农民科技培训2009，，6： | 1 |
| 13 | Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice显示文摘目的: Aripiprazole 是一个抑制精神的代理人对待精神分裂症,它通过多巴胺 D 2 扮演部分 agonism,血清素 5-HT 1A 部分 agonism 和 5-HT 2A 对抗。这研究被设计在 lipoperoxidation 上评估 neurobehavioral 效果和代理人,以及它的效果的 genotoxic/mutagenic 活动。 | Jaqueline Nascimento PICADA Bruna de Jesus Neto DOS SANTOS Franciele CELSO Jessica Dias MONTEIRO Kelly Morais DA ROSA Leandro Rosa CAMACHO Luciana Rodrigues VIEIRA Tars Madelon FREITAS Tatiana Grasiela DA SILVA Viviane Minuzzo PONTES Patricia PEREIRA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 1 |
| 14 | Storage temper- ature and type of cut affect the biochemical and physiological char- acteristics of fresh-cut purple onions 显示文摘 | NATALIA D B JAQUELINE V T CARLOS T S | 2014 | Postharvest Biology and Technology2014，93，： | 1 |
| 15 | Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response显示文摘 | Dazert Eva Neumann-Haefelin Christoph Bressanelli Stéphane Fitzmaurice Karen Kort Julia Timm J?rg McKiernan Susan Kelleher Dermot Gruener Norbert Tavis John E Rosen Hugo R Shaw Jaqueline Bowness Paul Blum Hubert E Klenerman Paul Bartenschla | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 16 | A protein with a novel calcium-binding domain associated with calcareous corpuscles in Echinococcus granulosus显示文摘 | Jaqueline SR Henrique BF Sandra EF | 1997 | Biochem Biophys Res Commun1997，237，2： | 1 |
| 17 | Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis brazilian patients显示文摘 | Catarina AJC Jaqueline de Azeve do Silva Will de BP | 2016 | Mol Biol Rep2016，43，： | 1 |
| 18 | Antimicrobial resistance of Clostridium difficile isolates in a tertiary medical center, Israel显示文摘 | Jihad Bishara Yoram Bloch Moshe Garty Jaqueline Behor Zmira Samra | 2006 | Diagnostic Microbiology & Infectious Disease2006，，2： | 1 |
| 19 | Involvement of lignin-modifying enzymes in the degradation of herbicides显示文摘 | Jaqueline da Silva Coelho-Moreira Giselle Mafia Maciel Rafael Castodi et ol | 2013 | Herbicides-Advances in Research2013，，： | 1 |
| 20 | Chloroquine reduces Th17 cell differentiation by stimulating T-bet expression in T cells显示文摘Chloroquine(CQ)is a weak base that was originally used to treat malaria infection.1 However,recent findings have pinpointed the modulatory effect of CQ in models of chronic inflammation and viral infections.The antiviral effect of CQ and its derivative hydroxychloroquine has attracted great attention due to the recent Sars-CoV-2 virus outbreak. | Rodolfo Thome Alexandra Boehm Larissa Lumi Watanabe Ishikawa Giacomo Casella Jaqueline Munhoz Bogoljub Ciric Guang-Xian Zhang Abdolmohamad Rostami | 2021 | Cellular & Molecular Immunology2021，18，3： | 1 |
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